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Histologically proven epithelial ingrowth in failed Descemet stripping automated endothelial keratoplasty (DSAEK) managed by repeat DSAEK

Authors Ghosh S, Bonshek R, Morgan SJ

Received 10 March 2013

Accepted for publication 22 April 2013

Published 31 May 2013 Volume 2013:7 Pages 1035—1040

DOI https://doi.org/10.2147/OPTH.S45016

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Saurabh Ghosh,1 Richard Bonshek,2 Stephen J Morgan1

1Sunderland Eye Infirmary, Sunderland, UK; 2National Specialist Ophthalmic Pathology Service (NSOPS) Laboratory, Department of Histopathology, Manchester Royal Infirmary, Manchester, UK

Purpose: To report a case of corneal graft failure due to epithelial ingrowth after an uneventful combined Descemet stripping automated endothelial keratoplasty (DSAEK) and phacoemulsification cataract surgery with intraocular lens implant treated successfully with a repeat DSAEK.
Methods: A 77-year-old male patient underwent combined DSAEK and phacoemulsification with intraocular lens implant implantation for Fuchs’ endothelial dystrophy plus cataract in the right eye. The donor cornea was cut on the Moria ALTK system and introduced using a suture pull-through technique. After an episode of endothelial rejection, the graft failed, with signs suggesting epithelial ingrowth. It was stripped from the host cornea using a Descemet’s membrane stripper, and a Simcoe irrigation-aspiration cannula was used to remove all traces of interface material. The excised lenticule was examined histologically using a hematoxylin and eosin stain.
Result: The patient regained and maintained excellent visual acuity with no sign of recurrence of epithelial ingrowth. Histopathological evaluation of the donor tissue of the first graft showed epithelial ingrowth on the stromal surface of the graft and very few endothelial cells, in keeping with the diagnosis of graft failure.
Conclusion: Epithelial ingrowth is a possible cause of endothelial graft failure, but histologically proven cases are rare. Surgical intervention can achieve successful clearance, with the potential for cure and an excellent outcome.

Keywords: epithelial ingrowth, Descemet stripping automated endothelial keratoplasty, graft failure

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