Back to Journals » International Journal of General Medicine » Volume 1

High prevalence of gastroesophageal reflux symptoms in patients with both acute and nonacute cough

Authors Urita Y, Watanabe T, Ota H, Iwata M, Sasaki Y, Maeda T, Ishii T, Nanami M, Nakayama A, Kato H, Hike K, Hara N, Sanaka M, Nagai Y, Watanabe S, Nakanishi K, Nakajima H, Sugimoto M

Published 29 October 2008 Volume 2008:1 Pages 59—63


Review by Single anonymous peer review

Peer reviewer comments 3

Yoshihisa Urita, Toshiyasu Watanabe, Hiroki Ota, Motohide Iwata, Yosuke Sasaki, et al

Department of General Medicine and Emergency Care, Toho University School of Medicine, Omori Hospital, Tokyo, Japan

Abstract: Although there have been many studies that showed a close association between gastroesophageal reflux disease (GERD) symptoms and chronic cough, it has been unknown whether acute cough is also associated with GERD. The aim of this study was to evaluate the relationship between GERD and respiratory symptoms in general practice. 1725 consecutive patients who first attended our hospital were enrolled in the present study. They were asked to respond the F-scale questionnaire regardless of their chief complaints. Over all, 656 (38%) patients were diagnosed as GERD and 226 (13%) had respiratory symptoms. Patients with respiratory symptoms had GERD symptoms more frequently than patients without respiratory symptoms (p < 0.05). Forty-three (37%) of 115 patients with acute cough and 48 (43%) of 111 with nonacute cough had GERD symptoms, suggesting that development of GERD is not associated with the period of respiratory symptoms. Patients with respiratory  symptoms are at a significantly increased risk of developing GERD. Whether or not treatment for GERD or respiratory diseases is useful for the prevention of respiratory symptoms and GERD, respectively, should not be driving management decisions in primary care.

Keywords: acute cough, gastroesophageal reflux, chronic cough, F-scale

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]