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High expression of Sam68 in sacral chordomas is associated with worse clinical outcomes

Authors Wen H, Li P, Ma H, Zheng J, Yu Y, Lv G

Received 27 July 2017

Accepted for publication 2 September 2017

Published 22 September 2017 Volume 2017:10 Pages 4691—4700


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Dr XuYu Yang

Hai Wen,1,* Pengzhi Li,1,* Hong Ma,1 Jiaoyun Zheng,2 Yipin Yu,1 Guohua Lv1

1Department of Spine Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; 2Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China

*These authors contributed equally to this work

Abstract: Src-associated in mitosis of 68 kDa (Sam68), also known as KHDRBS1 (KH domain-containing, RNA-binding, signal transduction-associated 1), is a member of the signal transduction and activation of RNA family. Previous studies have demonstrated that the aberrant expression of Sam68 is associated with the progression and prognosis of a variety of cancers, but little is known about its expression and role in chordomas, which are rare and aggressive bone neoplasms. In this study, we analyzed 40 tumor tissues and 20 distant normal tissues obtained from 40 patients with sacral chordoma using immunohistochemistry, and observed the expression of Sam68 was significantly upregulated in sacral chordomas compared with normal tissues (P=0.001). A positive correlation between the expression of Sam68 and the cell proliferation index Ki-67 was determined using Spearman’s rank correlation test (γ=0.599, P<0.001). In addition, high expression of Sam68 was significantly associated with surrounding muscle invasion (P<0.001). Moreover, Kaplan–Meier curves showed that patients with overexpressed Sam68 had shorter local recurrence-free survival time (P<0.001). Lastly, multivariate analysis indicated that Sam68 is an independent prognostic factor for the local recurrence-free survival of sacral chordomas (hazard ratio =5.929, 95% CI: 1.092–32.188, P=0.039). Our findings suggest the use of Sam68 as a predictor for the recurrence of sacral chordomas.

Keywords: sacral chordoma, Sam68, recurrence, prognostic factor

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