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High CEP55 expression is associated with poor prognosis in non-small-cell lung cancer

Authors Jiang C, Zhang Y, Li Y, Lu J, Huang Q, Xu R, Feng Y, Yan S

Received 16 February 2018

Accepted for publication 2 May 2018

Published 17 August 2018 Volume 2018:11 Pages 4979—4990

DOI https://doi.org/10.2147/OTT.S165750

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang


Chao Jiang,1 Yu Zhang,2 Yong Li,2 Jiabin Lu,2 Qitao Huang,2 Rui Xu,3 Yanfeng Feng,2 Shumei Yan2

1Department of Oncology, The People’s Hospital of Baoan District, Shenzhen, Guangdong, People’s Republic of China; 2Department of Pathology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People’s Republic of China; 3Department of Medical Oncology, Affiliated Tumor Hospital of Guangzhou Medical College, Guangzhou, People’s Republic of China

Objectives: Lung cancer is the most common and lethal malignancy worldwide. CEP55 was found to be overexpressed in multiple types of cancer. However, the expression pattern of CEP55 and its clinical significance in non-small-cell lung carcinoma (NSCLC) have not been investigated by immunohistochemistry.
Materials and methods: In this study, we analyzed 203 primary NSCLC specimens from Sun Yat-Sen University Cancer Center to investigate the clinical role of CEP55 in lung cancer. Tissue microarray was successfully generated for immunohistochemical evaluation. The correlation between CEP55 expression and clinical characteristics and survival was analyzed statistically. The predictive effect of CEP55 and APOBEC3B (AP3B) coexpression in lung cancer patients’ prognosis was evaluated.
Results: We found that the CEP55 expression was commonly elevated in NSCLC tissues and overexpression of CEP55 was correlated with unfavorable prognosis in the patients with NSCLC. Furthermore, the combination of CEP55 and AP3B expression was significantly predictive of clinical outcome in all NSCLC patients.
Conclusion: CEP55 may act as a useful and novel prognostic biomarker for NSCLC. Further studies into the mechanism of CEP55 are warranted.

Keywords: CEP55, non-small-cell lung cancer, immunohistochemistry, prognosis

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