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Hepatotoxicity induced by clozapine: a case report and review of literature

Authors Chou A, Lu M, Shen WW

Received 13 May 2014

Accepted for publication 12 June 2014

Published 26 August 2014 Volume 2014:10 Pages 1585—1587

DOI https://doi.org/10.2147/NDT.S67654

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Ana Isabel Wu Chou,1 Mong-Liang Lu,1,2 Winston W Shen1,2

1Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, 2Department of Psychiatry, School of Medicine, Taipei Medical University, Taipei, Taiwan

Abstract: Clozapine is an effective antipsychotic drug but is associated with serious side effects. Most treatment guidelines give no clear recommendations on regular monitoring of liver function tests, even though up to 60% of patients experience elevations in hepatic transaminases, with 15% to 30% experiencing an elevation two to three times greater than normal. Though elevations in liver function tests are often transient and asymptomatic, there are many reported cases of clozapine-induced hepatotoxicity, with damage to the liver, involvement of multiple organs, and even fulminant liver failure arising with moderate clozapine doses. This case report describes a Chinese woman who developed hepatotoxicity on a low dose of clozapine, and reviews the relevant literature.

Keywords: hepatitis, antipsychotic adverse effects, drug-induced liver injury

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