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Hepatorenal Syndrome Type 1: Current Challenges And Future Prospects

Authors Facciorusso A

Received 8 August 2019

Accepted for publication 5 November 2019

Published 27 November 2019 Volume 2019:15 Pages 1383—1391

DOI https://doi.org/10.2147/TCRM.S205328

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Nicola Ludin

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Antonio Facciorusso

Gastroenterology Unit, University of Foggia, Foggia, Italy

Correspondence: Antonio Facciorusso
Gastroenterology Unit, Department of Medical Sciences, University of Foggia, AOU Ospedali Riuniti, Viale Pinto, 1, Foggia 71100, Italy
Tel +39 0881732110
Fax +39 0881733545
Email antonio.facciorusso@virgilio.it

Abstract: Renal dysfunction represents a dreadful complication of advanced liver cirrhosis. In addition to the traditional types of acute kidney injury (AKI) that can occur in the general population, cirrhotics might experience a different kind of renal dysfunction, called hepatorenal syndrome (HRS). The exact definition of HRS is a functional renal dysfunction caused by overactivity of the endogenous vasoactive systems (in particular intrarenal circulation) which lead to reduced renal perfusion. Type I HRS (HRS-1) is characterized by an abrupt deterioration in renal function (in less than 2 weeks), defined by a doubling of baseline sCr to >2.5 mg/dL or a 50% reduction in the initial 24 hrs creatinine clearance to
 
Keywords: kidney, liver cirrhosis, terlipressin, mortality

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