Back to Journals » International Journal of Nanomedicine » Volume 7

Heparin nanomodification improves biocompatibility and biomechanical stability of decellularized vascular scaffolds

Authors Tao Y, Hu T, Wu Z, Tang H, Hu Y, Tan Q, Wu C

Received 17 August 2012

Accepted for publication 22 October 2012

Published 26 November 2012 Volume 2012:7 Pages 5847—5858

DOI https://doi.org/10.2147/IJN.S37113

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Yunming Tao,1,2 Tiehui Hu,1 Zhongshi Wu,1 Hao Tang,1 Yerong Hu,1 Qi Tan,1 Chunlin Wu1

1Department of Thoracic and Cardiovascular Surgery, Second Xiangya Hospital of Central South University, Changsha; 2Department of Thoracic and Cardiovascular Surgery, Ji'an Central People’s Hospital, Ji'an, Jiangxi Province, People's Republic of China

Abstract: Biocompatibility and biomechanical stability are two of the main obstacles limiting the effectiveness of vascular scaffolds. To improve the biomechanical stability and biocompatibility of these scaffolds, we created a heparin-nanomodified acellular bovine jugular vein scaffold by alternating linkage of heparin and dihydroxy-iron via self-assembly. Features of the scaffold were evaluated in vitro and in vivo. Heparin was firmly linked to and formed nanoscale coatings around the fibers of the scaffold, and the amount of heparin linked was about 808 ± 86 µg/cm2 (101 ± 11 USP/cm2) per assembly cycle. The scaffolds showed significantly strengthened biomechanical stability with sustained release of heparin for several weeks in vitro. Importantly, the modified scaffolds showed significantly reduced platelet adhesion, stimulated proliferation of endothelial cells in vitro, and reduced calcification in a subcutaneous implantation rat model in vivo. Heparin nanomodification improves the biocompatibility and biomechanical stability of vascular scaffolds.

Keywords: scaffolds, nanomodification, heparin, sustained release, biomechanical stability, biocompatibility

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia

Vlcek P, Bob P, Raboch J

Neuropsychiatric Disease and Treatment 2014, 10:1309-1315

Published Date: 14 July 2014

Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures

Blakney AK, Krogstad EA, Jiang YH, Woodrow KA

International Journal of Nanomedicine 2014, 9:2967-2978

Published Date: 17 June 2014

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

Development and characterization of a novel nanoemulsion drug-delivery system for potential application in oral delivery of protein drugs

Sun H, Liu K, Liu W, Wang W, Guo C, Tang B, Gu J, Zhang J, Li H, Mao X, Zou Q, Zeng H

International Journal of Nanomedicine 2012, 7:5529-5543

Published Date: 26 October 2012

Simple filter microchip for rapid separation of plasma and viruses from whole blood

Wang SQ, Sarenac D, Chen MH, Huang SH, Giguel FF, Kuritzkes DR, Demirci U

International Journal of Nanomedicine 2012, 7:5019-5028

Published Date: 17 September 2012

Electrospun PGA/gelatin nanofibrous scaffolds and their potential application in vascular tissue engineering

Hajiali H, Shahgasempour S, Naimi-Jamal MR, Peirovi H

International Journal of Nanomedicine 2011, 6:2133-2141

Published Date: 27 September 2011