Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Hemostatic absorbable gelatin sponge loaded with 5-fluorouracil for treatment of tumors

Authors Sun W, Chen Y, Yuan W, Hu Z

Received 11 December 2012

Accepted for publication 23 January 2013

Published 18 April 2013 Volume 2013:8(1) Pages 1499—1506


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Wei Sun,1 Yinghui Chen,2 Weien Yuan3

1School of Pharmaceutical Sciences, Jilin University, Changchun, People’s Republic of China; 2Department of Neurology, Jinshan Hospital, Fudan University, Jinshan District, Shanghai, People’s Republic of China; 3School of Pharmacy, Shanghai Jiao Tong University, Shanghai, People’s Republic of China

Background: Surgical tumor resection is the main treatment for tumors however the treatment process often results in massive bleeding and tumor cell residue. The main aim of this research was to address problems such as bleeding, systemic chemotherapy side effects while enhancing quality of life, and increasing drug concentrations at the tumor site by developing a novel formulation with local long-term efficacy for treatment of tumors and to stop bleeding.
Methods: 5-Fluorouracil (5-FU) was suspended in an ethyl acetate solution of poly D,L-lactide-co-glycolic acid (PLGA) and a vacuum drying method was applied. The hemostatic gelatin sponge loaded with 5-FU was prepared by absorption of the suspension. The in vitro and in vivo characteristics of the hemostatic gelatin sponge loaded with 5-FU (5-FU-HAGS) were investigated.
Results: 5-FU-HAGS (hemostatic absorbable gelatin sponge loaded with 5-fluorouracil) was successfully produced with controlled release of the content and was reproducibly suitable for local tumor treatment as an implant to stop bleeding. The encapsulation efficiency of 5-FU-HAGS was above 98%. The in vitro 5-FU release kinetic profile matched a near zero-order equation for 20 days. The in vivo 5-FU plasma concentration was at a more stable level than when 5-FU solution was administered by subcutaneous injection. Bleeding can be stopped more effectively by coating a piece of blank gelatin sponge. The survival ratio of tumor-bearing mice using a 5-FU-HAGS subcutaneous implant was higher when compared to mice given a subcutaneous injection of 5-FU solution.
Conclusion: The 5-FU-HAGS system is a potential and effective way of enhancing the survival ratio and improving the quality of life of tumor-bearing mice.

Keywords: absorbable gelatin sponge, 5-fluorouracil, sustained-release, tumor

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]


Other articles by this author:

Surgical release for tubercular elbow stiffness

Qian Y, Han Q, Wang W, Ouyang Y, Yuan W, Fan C

Infection and Drug Resistance 2018, 11:9-16

Published Date: 22 December 2017

Estrogen-mediated hemangioma-derived stem cells through estrogen receptor-α for infantile hemangioma

Zhang L, Wu H, Yuan W, Zheng J

Cancer Management and Research 2017, 9:279-286

Published Date: 7 July 2017

Biodegradable and biocompatible cationic polymer delivering microRNA-221/222 promotes nerve regeneration after sciatic nerve crush

Song J, Li X, Li Y, Che J, Li X, Zhao X, Chen Y, Zheng X, Yuan W

International Journal of Nanomedicine 2017, 12:4195-4208

Published Date: 2 June 2017

Propranolol therapy for infantile hemangioma: our experience

Zhang L, Wu HW, Yuan W, Zheng J

Drug Design, Development and Therapy 2017, 11:1401-1408

Published Date: 8 May 2017

Advances with microRNAs in Parkinson’s disease research

Ma L, Wei L, Wu F, Hu Z, Liu Z, Yuan W

Drug Design, Development and Therapy 2013, 7:1103-1113

Published Date: 1 October 2013

Long-acting preparations of exenatide

Cai Y, Wei L, Ma L, Huang X, Tao A, Liu Z, Yuan W

Drug Design, Development and Therapy 2013, 7:963-970

Published Date: 5 September 2013

pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein

Xu D, Wu F, Chen Y, Wei L, Yuan W

International Journal of Nanomedicine 2013, 8:3405-3414

Published Date: 2 September 2013

Advances with RNA interference in Alzheimer’s disease research

Chen S, Ge X, Chen Y, Lv N, Liu Z, Yuan W

Drug Design, Development and Therapy 2013, 7:117-125

Published Date: 22 February 2013

Sustained-release G-CSF microspheres using a novel solid-in-oil-in-oil-in-water emulsion method

Liu G, Hong X, Jiang M, Yuan W

International Journal of Nanomedicine 2012, 7:4559-4569

Published Date: 17 August 2012

Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats

Yang X, Zheng R, Cai Y, Liao M, Yuan W, Liu Z

International Journal of Nanomedicine 2012, 7:2077-2086

Published Date: 19 April 2012

A scalable fabrication process of polymer microneedles

Yang S, Feng Y, Zhang L, Chen N, Yuan W, Jin T

International Journal of Nanomedicine 2012, 7:1415-1422

Published Date: 12 March 2012

Readers of this article also read:

Emerging and future therapies for hemophilia

Carr ME, Tortella BJ

Journal of Blood Medicine 2015, 6:245-255

Published Date: 3 September 2015

Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles

Prozorova GF, Pozdnyakov AS, Kuznetsova NP, Korzhova SA, Emel’yanov AI, Ermakova TG, Fadeeva TV, Sosedova LM

International Journal of Nanomedicine 2014, 9:1883-1889

Published Date: 16 April 2014

A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone

Hu Z, Liao M, Chen Y, Cai Y, Meng L, Liu Y, Lv N, Liu Z, Yuan W

International Journal of Nanomedicine 2012, 7:5719-5724

Published Date: 12 November 2012

The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia

Rivka Yatuv, Micah Robinson, Inbal Dayan-Tarshish, et al

International Journal of Nanomedicine 2010, 5:581-591

Published Date: 6 August 2010

Crystallization after intravitreal ganciclovir injection

Pitipol Choopong, Nattaporn Tesavibul, Nattawut Rodanant

Clinical Ophthalmology 2010, 4:709-711

Published Date: 14 July 2010