Back to Journals » ClinicoEconomics and Outcomes Research » Volume 12

Healthcare Resource Utilization Pre- and Post-Initiation of Eslicarbazepine Acetate Among Pediatric Patients with Focal Seizure: Evidence from Routine Clinical Practice

Authors Mehta D, Davis M, Epstein AJ, Williams GR

Received 9 May 2020

Accepted for publication 3 July 2020

Published 23 July 2020 Volume 2020:12 Pages 379—387

DOI https://doi.org/10.2147/CEOR.S261960

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Giorgio Lorenzo Colombo


Darshan Mehta,1 Matthew Davis,2 Andrew J Epstein,2 G Rhys Williams1

1Health Economics and Outcomes Research, Sunovion Pharmaceuticals Inc., Marlborough, MA, USA; 2Health Economics and Outcomes Research, Medicus Economics, LLC, Milton, MA, USA

Correspondence: Darshan Mehta
Health Economics and Outcomes Research, 84 Waterford Drive, Marlborough, MA 01752, USA
Tel +1-774-369-7913
Email Darshan.Mehta@sunovion.com

Objective: To examine the impact of initiating treatment with eslicarbazepine acetate (ESL) on healthcare resource utilization (HCRU) among pediatric patients with focal seizures (FS).
Methods: This retrospective study used Symphony Health’s Integrated Dataverse® claims data. Patients aged 4 to 17 years with a diagnosis of FS and a new prescription for ESL between April 2015 and June 2018 were included and defined as the overall patient population. Index date was the first dispensed claim for ESL. Baseline period was the 90-day block immediately prior to the index date. The follow-up period comprised up to 4 consecutive 90-day blocks immediately following the index date. Subgroups were defined based on the presence (DP+) or absence (DP−) of developmental and/or psychiatric disorders at baseline. All-cause and FS-related inpatient (IP), emergency room (ER), outpatient (OP) hospital, and office (OF) visits were measured during the follow-up period. Reduction in HCRU per block in the post-ESL period was assessed using fixed-effects linear regression models.
Results: A total of 234 patients were included in the overall study population, of whom 86 (36.8%) were DP+ and 148 (63.2%) were DP−. Relative to the baseline period, significant reductions were observed in the overall population for all-cause ER (P=0.001), OP (P< 0.001), and OF (P< 0.001) visits and FS-related IP (P=0.037) and OF (P< 0.001) visits in the follow-up period. Among DP+ and DP− patients, significant reductions were observed for all-cause ER (DP+: P=0.024; DP−: P=0.017), OP (DP+: P< 0.001; DP−: P=0.035), and OF (DP+: P=0.004; DP−: P=0.001) visits during the follow-up period. No significant differences were observed between DP+ and DP− patients in the change in all-cause or FS-related HCRU from baseline to the follow-up period.
Conclusion: Pediatric patients with FS (DP+ and DP-) who initiated ESL had significant reductions in all-cause ER, OP, and OF visits and FS-related IP and OF visits.

Keywords: eslicarbazepine acetate, focal seizure, health resource utilization, pediatric

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]