Back to Journals » Patient Related Outcome Measures » Volume 11

Health-Related Quality of Life Among People Living with Human Immunodeficiency Virus on Highly Active Antiretroviral Therapy in Ethiopia: PROQOL-HIV Based Survey

Authors Melaku T, Mamo G, Chelkeba L, Chanie T

Received 20 November 2019

Accepted for publication 23 February 2020

Published 5 March 2020 Volume 2020:11 Pages 73—86

DOI https://doi.org/10.2147/PROM.S239429

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Lynne Nemeth


Tsegaye Melaku, Girma Mamo, Legese Chelkeba, Tesfahun Chanie

Department of Clinical Pharmacy, School of Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia

Correspondence: Tsegaye Melaku Tel +251 91 376 5609
Email tsegaye.melaku@ju.edu.et

Background: As infection with the Human Immunodeficiency Virus (HIV) has evolved into a chronic disease, perceived health-related quality of life (HRQoL) is becoming a prominent and important patient-reported outcome measure in HIV care. This study aimed to assess HRQoL among people living with HIV on highly active antiretroviral therapy and factors associated with HRQoL in Ethiopia.
Methods: An institution-based cross-sectional study was conducted among 160 HIV–infected patients who were initiated highly active antiretroviral therapy at Jimma University Medical Center in 2016. HRQoL was assessed using the patient-reported outcome quality of life-HIV (PROQOL-HIV) measuring scale. Linear regressions were used to identify factors associated with outcome. Statistical significance was considered at p-value < 0.05.
Results: Out of a total of 160 participants, 63.13% were females. The mean (±SD) age of study participants was 41.47± 9.45 years. The median baseline CD4+ cell count was 182.00 cells/μL (IQR: 104.53– 262.40 cells/μL). The mean (±SD) score of PROQOL-HIV scale domains was 77.58 ± 15.11, 58.32 ± 7.79, 61.75± 17.95, 85.07 ± 15.67, 76.92 ± 20.52, 80.00 ± 16.83, 74.37 ± 1.47, 81.45 ± 8.17 for physical health and symptoms, emotional distress, health concerns, body change, intimate relationships, social relationships, stigma, and treatment impact domains, respectively. Second line antiretroviral therapy showed a negative effect on the quality of life, especially on the treatment impact domain (β=− 6.301). Cotrimoxazole preventive therapy had a significant positive effect on the physical health and symptoms of HIV patients (β= +8.381, p< 0.05). Advanced disease (β=− 2.709, p< 0.05), and non-communicable disease comorbidity (β=− 14.340, p< 0.001) showed a significant negative effect on physical health and symptoms.
Conclusion: Several behavioral, clinical & immunological factors were negatively associated with health-related quality of life. The double burden of chronic non-communicable disease(s) and the impact of treatment were highly significant in all dimensions of HRQoL measures. Therefore, with HRQoL emerging as a key issue for HIV–infected patients, its routine assessment and appropriate interventions at each clinic visit would be very crucial.

Keywords: human immunodeficiency virus, health-related quality of life, patient-reported outcome


Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]