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HA/nylon 6,6 porous scaffolds fabricated by salt-leaching/solvent casting technique: effect of nano-sized filler content on scaffold properties

Authors Mehrabanian M, Nasr-Esfahani M

Published 11 August 2011 Volume 2011:6 Pages 1651—1659

DOI https://doi.org/10.2147/IJN.S21203

Review by Single-blind

Peer reviewer comments 3

Mehran Mehrabanian1, Mojtaba Nasr-Esfahani2
1Member of Young Researchers Club, Najafabad Branch, Islamic Azad University, Isfahan, Iran; 2Department of Materials Science and Engineering, Najafabad Branch, Islamic Azad University, Isfahan, Iran

Abstract: Nanohydroxyapatite (n-HA)/nylon 6,6 composite scaffolds were produced by means of the salt-leaching/solvent casting technique. NaCl with a distinct range size was used with the aim of optimizing the pore network. Composite powders with different n-HA contents (40%, 60%) for scaffold fabrication were synthesized and tested. The composite scaffolds thus obtained were characterized for their microstructure, mechanical stability and strength, and bioactivity. The microstructure of the composite scaffolds possessed a well-developed interconnected porosity with approximate optimal pore size ranging from 200 to 500 µm, ideal for bone regeneration and vascularization. The mechanical properties of the composite scaffolds were evaluated by compressive strength and modulus tests, and the results confirmed their similarity to cortical bone. To characterize bioactivity, the composite scaffolds were immersed in simulated body fluid for different lengths of time and results monitored by scanning electron microscopy and energy dispersive X-ray microanalysis to determine formation of an apatite layer on the scaffold surface.

Keywords: scaffold, nanohydroxyapatite, nylon 6,6, salt-leaching/solvent casting, bioactivity

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