Hand grip strength is associated with forced expiratory volume in 1 second among subjects with COPD: report from a population-based cohort study
Authors Strandkvist VJ, Backman H, Röding J, Stridsman C, Lindberg A
Received 2 June 2016
Accepted for publication 7 July 2016
Published 7 October 2016 Volume 2016:11(1) Pages 2527—2534
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Professor Hsiao-Chi Chuang
Peer reviewer comments 2
Editor who approved publication: Dr Richard Russell
Viktor Johansson Strandkvist,1,2 Helena Backman,2 Jenny Röding,1 Caroline Stridsman,3 Anne Lindberg4
1Division of Health and Rehabilitation, Department of Health Science, Luleå University of Technology, Luleå, 2Division of Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, The Obstructive Lung disease in Northern Sweden Unit, Umeå University, Umeå, 3Division of Nursing, Department of Health Science, Luleå University of Technology, Luleå, 4Division of Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Background: Cardiovascular diseases and skeletal muscle dysfunction are common comorbidities in COPD. Hand grip strength (HGS) is related to general muscle strength and is associated with cardiovascular disease and all-cause mortality, while the results from small selected COPD populations are contradictory. The aim of this population-based study was to compare HGS among the subjects with and without COPD, to evaluate HGS in relation to COPD severity, and to evaluate the impact of heart disease.
Subjects and methods: Data were collected from the Obstructive Lung disease in Northern Sweden COPD study, where the subjects with and without COPD have been invited to annual examinations since 2005. In 2009–2010, 441 subjects with COPD (postbronchodilator forced expiratory volume in 1 second [FEV1]/ vital capacity <0.70) and 570 without COPD participated in structured interviews, spirometry, and measurements of HGS.
Results: The mean HGS was similar when comparing subjects with and without COPD, but those with heart disease had lower HGS than those without. When compared by Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades, the subjects with GOLD 3–4 had lower HGS than those without COPD in both sexes (females 21.4 kg vs 26.9 kg, P=0.010; males 41.5 kg vs 46.3 kg, P=0.038), and the difference persisted also when adjusted for confounders. Among the subjects with COPD, HGS was associated with FEV1% of predicted value but not heart disease when adjusted for height, age, sex, and smoking habits, and the pattern was similar among males and females.
Conclusion: In this population-based study, the subjects with GOLD 3–4 had lower HGS than the subjects without COPD. Among those with COPD, HGS was associated with FEV1% of predicted value but not heart disease, and the pattern was similar in both sexes.
Keywords: muscle strength, muscle strength dynamometer, pulmonary disease, COPD, heart diseases, epidemiology
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