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Half-dose photodynamic therapy for serous non-neovascular retinal pigment epithelial detachment

Authors Inoda S, Takahashi H, Inoue Y, Tampo H, Sakamoto S, Arai Y, Kawashima H, Yanagi Y

Received 3 December 2018

Accepted for publication 26 April 2019

Published 6 June 2019 Volume 2019:13 Pages 959—968

DOI https://doi.org/10.2147/OPTH.S196901

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser


Satoru Inoda,1 Hidenori Takahashi,1 Yuji Inoue,1 Hironobu Tampo,1 Shinichi Sakamoto,1 Yusuke Arai,1 Hidetoshi Kawashima,1 Yasuo Yanagi2

1Ophthalmology, Jichi Medical University, Shimotsuke-Shi, Tochigi, 329-0431, Japan; 2Ophthalmology, Asahikawa Medical University, Asahikawa-Shi, Hokkaido, 078-8510, Japan

Purpose: To investigate the efficacy of half-dose photodynamic therapy (PDT) for treating symptomatic serous non-neovascular pigment epithelial detachment (PED) and to identify factors associated with treatment outcome.
Patients and methods: This is a single-institute retrospective case series involving 12 eyes of 12 consecutive patients with serous non-neovascular PED who received half-dose PDT. We investigated the temporal change in best-corrected visual acuity (BCVA), the anatomic outcomes of PED, including recurrence, central choroidal thickness (CCT), and also choroidal thickness as a possible factor associated with treatment outcome.
Results: At baseline, mean logMAR BCVA was 0.06 (range Snellen equivalent 6/20 to 24/20); 24 months later, it was 0.01 (Snellen equivalent 6/20 to 24/20; P=0.3). At 3 months, PED had completely flattened in 8, decreased in height in 2, and remained unchanged in 2. The CCT in eyes with PED was 410 μm and thicker than that in fellow eyes (290 μm, P<0.0001). Recurrence was noted in 2 within 12 months after treatment. Eyes in which the choroidal thickness with a baseline CCT >350μm or a 100 μm difference in CCT responded favorably to half-dose PDT (P=0.02).
Conclusion: Half-dose PDT is effective in patients with non-neovascular PED. Thicker choroid and some difference in CCT between affected and fellow eye might be a good index for predicting the efficacy of this treatment.

Keywords: epithelial detachment, serous pigment epithelial detachment, non-neovascular pigment photodynamic therapy, photodynamic therapy

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