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GSTM1 polymorphism is related to risks of nasopharyngeal cancer and laryngeal cancer: a meta-analysis

Authors Zhang F, Wu X, Niu J, Kang X, Cheng L, Lv Y, Wu M

Received 4 January 2017

Accepted for publication 3 February 2017

Published 6 March 2017 Volume 2017:10 Pages 1433—1440


Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ru Chen

Peer reviewer comments 3

Editor who approved publication: Dr Yao Dai

Fengying Zhang,1,* Xijiang Wu,2,* Jinming Niu,1 Xiufeng Kang,3 Liya Cheng,1 Yanchun Lv,1 Meimei Wu1

1Otorhinolaryngological Department, Wei Fang Traditional Chinese Hospital, Weifang, Shandong Province, China; 2Otorhinolaryngological Department, Shouguang Peoples Hospital, Shouguang, Shandong Province, China; 3Medical insurance office, Shouguang Peoples Hospital, Shouguang, Shandong Province, China

*These authors contributed equally to this work

Background: Accumulating data have reported that GSTM1 polymorphism may be related to nasopharyngeal cancer (NPC) and laryngeal cancer (LC). This meta-analysis was performed to investigate the relationship between GSTM1 polymorphism and risks of NPC and LC.
Methods: Pubmed, Embase, and China National Knowledge Infrastructure (CNKI) databases were searched for potential articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the relationship of GSTM1 polymorphism with the risks of NPC and LC. I2>50% or P<0.05 indicates significant heterogeneity. When heterogeneity existed, the random-effects model was used to pool data, otherwise, the fixed-effects model was adopted. Publication bias was detected by Begg’s funnel plot and Egger’s regression. Quality of each study was evaluated by Newcastle-Ottawa Scale.
Results: Thirty-two eligible articles were included. Pooled outcome suggested the significant relationship of GSTM1 null genotype with increased risk of LC (OR =1.28, 95% CI =1.05–1.54). Compared with hospital-based (HB) population, GSTM1 null genotype was also related to increased risk of LC (OR =1.38, 95% CI =1.06–1.80). Positive relationship of GSTM1 null genotype with enhanced risk of NPC was observed (OR =1.43, 95% CI =1.26–1.63). A similar trend was also observed in the subgroup analysis by source of control (population-based [PB]: OR =1.39, 95% CI =1.18–1.63; HB: OR =1.52, 95% CI =1.22–1.89).
Conclusion: GSTM1 null genotype is related to increased risk of NPC and LC.

Keywords: GSTM1, polymorphism, NPC, LC

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