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Gold quantum dots impair the tumorigenic potential of glioma stem-like cells via β-catenin downregulation in vitro

Authors Wahab R, Kaushik N, Khan F, Kaushik NK, Lee SJ, Choi EH, Al-Khedhairy AA

Received 20 November 2018

Accepted for publication 4 January 2019

Published 13 February 2019 Volume 2019:14 Pages 1131—1148

DOI https://doi.org/10.2147/IJN.S195333

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Thomas Webster


Rizwan Wahab,1,2,* Neha Kaushik,3,* Farheen Khan,4 Nagendra Kumar Kaushik,5 Su-Jae Lee,3 Eun Ha Choi,5 Abdulaziz A Al-Khedhairy1

1Zoology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; 2Al-Jeraisy, Chair for DNA Research, King Saud University, Riyadh 11451, Saudi Arabia; 3Department of Life Science, Hanyang University, Seoul 04763, South Korea; 4Chemistry Department, Faculty of Science, Taibah University, Yanbu 42353, Saudi Arabia; 5Plasma Bioscience Research Center/Applied Plasma Medicine Center, Department of Electrical and Biological Physics, Kwangwoon University, Seoul 01897, South Korea

*These authors contributed equally to this work

Background: Over the past several decades, the incidence of solid cancers has rapidly increased worldwide. Successful removal of tumor-initiating cells within tumors is essential in the field of cancer therapeutics to improve patient disease-free survival rates. The biocompatible multivarient-sized gold nanoparticles (MVS-GNPs) from quantum dots (QDs,
Methods: Herein, MVS-GNPs synthesized and characterized by means of X-ray diffraction pattern (XRD) and transmission electron microscopy (TEM) techniques. Afterwards, interaction of these GNPs with glioma stem-cell like cells along with cancer cells were evaluated by MTT, cell motility, self-renewal assays and biostatistics was also applied.
Results: Among these GNPs, G-QDs contributed to reduce metastatic events and spheroid cell growth, potentially blocking the self-renewal ability of these cells. This study also uncovers the previously unknown role of the inhibition of CTNNB1 signaling as a novel candidate to decrease the tumorigenesis of glioma spheroids and subsequent spheroid growth. The accurate and precise biostatistics results were obtained at quantify level.
Conclusion: In summary, G-QDs may exhibit possible contribution on suppressing the growth of tumor-initiating cells. These data reveal a unique therapeutic approach for the elimination of residual resistant stem-like cells during cancer treatment.

Keywords: multivarient gold nanoparticles, epithelial-mesenchymal transition, solid tumor, brain cancer, self-renewal, cellular movement, biostatistics

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