Gene ID	Location	Sample Name	VFDB ID	VFs	Species	Description	Level1	Level2	Identity(%)	Evalue	Score	Coverage(%)
gene0002	Chromosome	HI108	VFG000338(gb|NP_439157)	Tbp (VF0267)	Haemophilus influenzae Rd KW20	-	Nonspecific virulence factor	Iron uptake system	93.4	0	4446	100
gene0003	Chromosome	HI108	VFG000339(gb|NP_439158)	Tbp (VF0267)	Haemophilus influenzae Rd KW20	-	Nonspecific virulence factor	Iron uptake system	68.7	6.40E-230	2042	99.7
gene0027	Chromosome	HI108	VFG000705(gb|AAP42197)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	98.3	3.00E-249	2207	100
gene0028	Chromosome	HI108	VFG000704(gb|AAP42196)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	96.1	0	3010	87.5
gene0029	Chromosome	HI108	VFG000703(gb|AAP42195)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	97.7	0	3116	100
gene0030	Chromosome	HI108	VFG000702(gb|AAP42194)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	99.7	0	6346	100
gene0031	Chromosome	HI108	VFG000701(gb|AAP42193)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	100	9.50E-218	1935	100
gene0032	Chromosome	HI108	VFG000700(gb|AAP42192)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	99.4	2.20E-267	2364	100
gene0033	Chromosome	HI108	VFG000699(gb|AAP42191)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	100	3.70E-220	1956	100
gene0034	Chromosome	HI108	VFG000698(gb|AAP42190)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	100	7.80E-193	1720	100
gene0035	Chromosome	HI108	VFG000697(gb|AAP42189)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	99.6	6.30E-147	1323	100
gene0036	Chromosome	HI108	VFG000696(gb|AAP42188)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	100	1.50E-125	1138	100
gene0040	Chromosome	HI108	VFG000705(gb|AAP42197)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	98.3	3.00E-249	2207	100
gene0041	Chromosome	HI108	VFG000704(gb|AAP42196)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	96.1	0	3010	87.5
gene0042	Chromosome	HI108	VFG000703(gb|AAP42195)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	97.7	0	3116	100
gene0043	Chromosome	HI108	VFG000702(gb|AAP42194)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	99.7	0	6346	100
gene0044	Chromosome	HI108	VFG000701(gb|AAP42193)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	100	9.50E-218	1935	100
gene0045	Chromosome	HI108	VFG000700(gb|AAP42192)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	99.4	2.20E-267	2364	100
gene0046	Chromosome	HI108	VFG000699(gb|AAP42191)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	100	3.70E-220	1956	100
gene0047	Chromosome	HI108	VFG000698(gb|AAP42190)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	100	7.80E-193	1720	100
gene0048	Chromosome	HI108	VFG000697(gb|AAP42189)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	99.6	6.30E-147	1323	100
gene0049	Chromosome	HI108	VFG000696(gb|AAP42188)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	100	7.40E-17	194	94.7
gene0052	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	36.7	1.80E-35	361	96.7
gene0053	Chromosome	HI108	VFG047512(gb|YP_169930.1)	Biotin synthesis (VF0552)	Francisella tularensis subsp. tularensis SCHU S4	"Critical for rapid phagosomal escape. Sequestration of biotin could restrict Francisella to the phagosome, blocking their escape and preventing them from reaching their replicative niche in the cytoplasm"	-	-	49.3	2.50E-84	784	90.4
gene0071	Chromosome	HI108	VFG007023(gb|NP_231091)	RTX toxin (CVF263)	Vibrio cholerae O1 biovar El Tor str. N16961	-	Offensive virulence factors	Toxin	31	6.30E-57	550	85.5
gene0078	Chromosome	HI108	VFG013384(gb|NP_439218)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99.2	1.10E-221	1969	100
gene0079	Chromosome	HI108	VFG013390(gb|NP_439219)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.9	6.60E-149	1340	100
gene0080	Chromosome	HI108	VFG011399(gb|NP_539749)	LPS (CVF383)	Brucella melitensis bv. 1 str. 16M	Plays a role in entry and early survival inside macrophages.Resistance to innate-immunity anti-bacterial responses.A modulator of the immune response;	-	-	45.9	8.30E-32	328	96.6
gene0095	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	35.4	8.10E-35	356	94.9
gene0104	Chromosome	HI108	VFG001206(gb|NP_273675)	FbpABC (VF0272)	Neisseria meningitidis MC58	"Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein"	Nonspecific virulence factor	Iron uptake system	33.3	7.90E-25	270	79.5
gene0105	Chromosome	HI108	VFG001867(gb|YP_096960)	SodB (VF0169)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	A cytoplasmic iron superoxide dismutase; important for intracellular survival and transmission	Defensive virulence factors	Stress protein	42.3	3.20E-45	445	97.2
gene0106	Chromosome	HI108	VFG010862(gb|YP_094891)	Cytochrome c maturation (ccm) locus (CVF358)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	-	Nonspecific virulence factor	Iron uptake system	35.8	9.10E-32	329	91
gene0107	Chromosome	HI108	VFG010866(gb|YP_094892)	Cytochrome c maturation (ccm) locus (CVF358)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	-	Nonspecific virulence factor	Iron uptake system	42.9	4.70E-39	392	98.2
gene0108	Chromosome	HI108	VFG001856(gb|YP_094893)	CcmC (VF0292)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	"Required for cytochrome c production, promotes iron assimilation and intracellular infection"	Nonspecific virulence factor	Iron uptake system	50.6	1.40E-68	647	97.2
gene0110	Chromosome	HI108	VFG010878(gb|YP_094895)	Cytochrome c maturation (ccm) locus (CVF358)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	-	Nonspecific virulence factor	Iron uptake system	47.1	7.50E-32	329	80.9
gene0111	Chromosome	HI108	VFG010882(gb|YP_094896)	Cytochrome c maturation (ccm) locus (CVF358)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	-	Nonspecific virulence factor	Iron uptake system	48.9	2.70E-175	1571	98.8
gene0122	Chromosome	HI108	VFG013400(gb|NP_439262)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99.4	7.30E-204	1815	100
gene0127	Chromosome	HI108	VFG013070(gb|YP_405013)	Shu (VF0256)	Shigella dysenteriae Sd197	"Shu heme utilization locus includes:; ShuA, TonB-denpendent heme receptor which is critical for the uptake of heme into the periplasm,; ShuT, putative periplasmic binding protein which specifically binds heme and acts as a soluble receptor for active uptake of heme into the cytoplasm; ShuU and ShuV comprise the cytoplasmic membrane permease and ATPase; ShuS, soluble cytoplasmic protein may function as a heme storage proteins during periods of active heme transport and as a DNA binding protein to protect the DNA from heme mediated oxidative damage"	Nonspecific virulence factor	Iron uptake system	27.8	1.20E-13	176	44.7
gene0131	Chromosome	HI108	VFG000332(gb|NP_439271)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99	1.70E-183	1639	100
gene0137	Chromosome	HI108	VFG007023(gb|NP_231091)	RTX toxin (CVF263)	Vibrio cholerae O1 biovar El Tor str. N16961	-	Offensive virulence factors	Toxin	32.4	3.50E-22	248	70.5
gene0138	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	27.5	7.90E-19	219	76.2
gene0159	Chromosome	HI108	VFG013412(gb|NP_439302)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99.3	2.20E-175	1569	100
gene0163	Chromosome	HI108	VFG001206(gb|NP_273675)	FbpABC (VF0272)	Neisseria meningitidis MC58	"Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein"	Nonspecific virulence factor	Iron uptake system	33.8	3.30E-30	316	90
gene0171	Chromosome	HI108	VFG013248(gb|NP_438233)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	25.5	9.70E-44	436	99
gene0172	Chromosome	HI108	VFG000365(gb|NP_405474)	Yersiniabactin (VF0136)	Yersinia pestis CO92	"FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron"	Nonspecific virulence factor	Iron uptake system	25.3	2.30E-40	407	96.9
gene0178	Chromosome	HI108	VFG000335(gb|NP_439322)	P5 protein (VF0041)	Haemophilus influenzae Rd KW20	"Interacts with CEACAM1, a member of the carcinoembryonic antigen (CEA) family of cell adhesion molecules, a glycoprotein expressed by respiratory epithelial cell"	Offensive virulence factors	Adherence	94.1	4.80E-187	1670	100
gene0188	Chromosome	HI108	VFG037153(gb|NP_273705)	NspA (VF0453)	Neisseria meningitidis MC58	Binds complement factor H to inhibit host innate immune defenses	-	-	32.1	3.00E-17	203	91.8
gene0193	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	36.6	6.60E-34	348	90.9
gene0194	Chromosome	HI108	VFG013418(gb|NP_439337)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.5	5.10E-106	969	100
gene0196	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	31	1.20E-30	321	81.7
gene0197	Chromosome	HI108	VFG001206(gb|NP_273675)	FbpABC (VF0272)	Neisseria meningitidis MC58	"Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein"	Nonspecific virulence factor	Iron uptake system	30.9	1.90E-20	233	73.9
gene0209	Chromosome	HI108	VFG049114(gb|YP_002918199.1)	Allantion utilization (VF0572)	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	Providing a nitrogen source to increase virulence in K. pneumoniae at certain sites of infection	-	-	27.5	3.40E-08	127	66.3
gene0267	Chromosome	HI108	VFG005776(gb|NP_687685)	Beta-hemolysin/cytolysin (CVF171)	Streptococcus agalactiae 2603V/R	-	Offensive virulence factors	Toxin	25.7	1.10E-15	194	40.3
gene0272	Chromosome	HI108	VFG014950(gb|NP_249457)	Alginate regulation (CVF523)	Pseudomonas aeruginosa PAO1	-	Defensive virulence factors	Antiphagocytosis	36.4	1.80E-69	657	95.2
gene0282	Chromosome	HI108	VFG013069(gb|YP_405014)	Shu (VF0256)	Shigella dysenteriae Sd197	"Shu heme utilization locus includes:; ShuA, TonB-denpendent heme receptor which is critical for the uptake of heme into the periplasm,; ShuT, putative periplasmic binding protein which specifically binds heme and acts as a soluble receptor for active uptake of heme into the cytoplasm; ShuU and ShuV comprise the cytoplasmic membrane permease and ATPase; ShuS, soluble cytoplasmic protein may function as a heme storage proteins during periods of active heme transport and as a DNA binding protein to protect the DNA from heme mediated oxidative damage"	Nonspecific virulence factor	Iron uptake system	38.3	1.00E-48	477	83.7
gene0283	Chromosome	HI108	VFG037046(gb|NP_273632)	MntABC (VF0455)	Neisseria meningitidis MC58	Quenches ROS that is independent of superoxide dismutase and catalase	Defensive virulence factors	Stress protein	32.4	8.40E-24	261	84.3
gene0288	Chromosome	HI108	VFG043350(gb|YP_095809)	polar flagella (AI149)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	-	-	-	28.5	2.10E-15	190	65.4
gene0290	Chromosome	HI108	VFG013424(gb|NP_439432)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.2	4.10E-123	1117	100
gene0292	Chromosome	HI108	VFG039491(gb|NP_820417)	T4SS effectors (CVF803)	Coxiella burnetii RSA 493	Facilitates the translocation of many bacterial effector proteins across the bacterial and vacuole membranes to enter the host cytoplasm where the effector proteins mediate their specific activities to manipulate a variety of host cell processes	Offensive virulence factors	Secretion system	42.9	9.40E-31	319	96.7
gene0313	Chromosome	HI108	VFG001206(gb|NP_273675)	FbpABC (VF0272)	Neisseria meningitidis MC58	"Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein"	Nonspecific virulence factor	Iron uptake system	30.3	5.10E-17	206	35.5
gene0364	Chromosome	HI108	VFG000160(gb|NP_251087)	Pyoverdine (VF0094)	Pseudomonas aeruginosa PAO1	Effective at acquiring iron from transferrin and lactoferrin; cytotoxic due to its ability to stimulating the production of reactive oxygen species	Nonspecific virulence factor	Iron uptake system	33.1	1.10E-12	167	37.3
gene0374	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	34.6	3.20E-59	568	92.7
gene0406	Chromosome	HI108	VFG009810(gb|NP_215272)	PhoP/R (CVF331)	Mycobacterium tuberculosis H37Rv	-	Regulation of virulence-associated genes	Regulation	24.9	1.50E-20	235	60
gene0407	Chromosome	HI108	VFG038219(gb|YP_001845364)	BfmRS (VF0463)	Acinetobacter baumannii ACICU	"Controls biofilm formation and cellular morphology; participates in cell adhesion, resistance to serum killing and antibiotic susceptibility"	Regulation of virulence-associated genes	Regulation	32.7	1.60E-26	284	95.2
gene0408	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	29.7	3.80E-24	264	94.9
gene0493	Chromosome	HI108	VFG047564(gb|YP_169890.1)	Purine biosynthesis (VF0559)	Francisella tularensis subsp. tularensis SCHU S4	Required for bacterial cytosolic replication	-	-	43.3	5.20E-77	721	96.8
gene0494	Chromosome	HI108	VFG005767(gb|NP_687682)	Beta-hemolysin/cytolysin (CVF171)	Streptococcus agalactiae 2603V/R	-	Offensive virulence factors	Toxin	29.8	4.40E-17	203	86.1
gene0521	Chromosome	HI108	VFG037100(gb|NP_273110)	MsrAB (VF0456)	Neisseria meningitidis MC58	Repairs oxidized proteins	Defensive virulence factors	Stress protein	62.6	4.80E-118	1075	88.4
gene0526	Chromosome	HI108	VFG000121(gb|NP_249453)	Alginate (VF0091)	Pseudomonas aeruginosa PAO1	"Allows the bacteria form biofilm; contributes to the persistence of the bacteria in the CF lung: act as an adhesin, preventing the bacteria from being expelled from the lung, and alginate slime layer makes it more difficult for phagocytes to ingest and kill the bacteria"	Defensive virulence factors;Defensive virulence factors	Antiphagocytosis;Serum resistance	26.1	6.40E-10	140	97.2
gene0527	Chromosome	HI108	VFG020191(gb|YP_001874638)	YadA (VF0133)	Yersinia pseudotuberculosis PB1/+	-	-	-	40	4.10E-12	157	84.1
gene0528	Chromosome	HI108	VFG037735(gb|YP_001847165)	AdeFGH efflux pump (VF0504)	Acinetobacter baumannii ACICU	Play a potential role in the synthesis and transport of autoinducer molecules during biofilm formation	-	-	26.2	2.30E-24	268	98.7
gene0537	Chromosome	HI108	VFG037260(gb|YP_001847232)	Acinetobactin (VF0467)	Acinetobacter baumannii ACICU	High-affinity catechol-hydroxamate siderophore competing with host cells for iron	Nonspecific virulence factor	Iron uptake system	29.6	9.10E-13	169	35.1
gene0540	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	29	1.60E-19	224	80.2
gene0541	Chromosome	HI108	VFG000922(gb|NP_756179)	Chu (VF0227)	Escherichia coli CFT073	"Iron uptake: the ability to use heme and/or hemoglobin might be especially advantageous to pathogenic bacteria. These pathogens often secrete cytotoxins, which gain access to the intracellular heme reservoir besides initiating tissue invasion. Cytotoxin production coupled with the capability to utilize heme and/or hemoglobin could serve as an effective iron acquisition strategy during the progression of infection"	Nonspecific virulence factor	Iron uptake system	35.5	5.00E-48	471	97.3
gene0544	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	38.1	3.80E-32	332	100
gene0547	Chromosome	HI108	VFG000331(gb|NP_439675)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.7	1.20E-270	2392	100
gene0548	Chromosome	HI108	VFG013436(gb|NP_439676)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97.1	1.20E-184	1649	100
gene0554	Chromosome	HI108	VFG049149(gb|YP_006635475.1)	Colibactin (VF0573)	Klebsiella pneumoniae subsp. pneumoniae 1084	Inducing DNA damage;	Offensive virulence factors	Toxin	28.8	7.60E-19	220	79.8
gene0556	Chromosome	HI108	VFG000326(gb|NP_439686)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99.3	7.20E-154	1384	74.4
gene0557	Chromosome	HI108	VFG000327(gb|NP_439687)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	100	1.30E-158	1424	100
gene0558	Chromosome	HI108	VFG000328(gb|NP_439688)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97	7.70E-133	1201	100
gene0559	Chromosome	HI108	VFG000329(gb|NP_439689)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	88.1	2.60E-140	1266	100
gene0569	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	35.6	1.80E-30	318	90.3
gene0570	Chromosome	HI108	VFG047461(gb|YP_169927.1)	Biotin synthesis (VF0552)	Francisella tularensis subsp. tularensis SCHU S4	"Critical for rapid phagosomal escape. Sequestration of biotin could restrict Francisella to the phagosome, blocking their escape and preventing them from reaching their replicative niche in the cytoplasm"	-	-	27.2	1.20E-12	164	81.2
gene0577	Chromosome	HI108	VFG013465(gb|NP_439706)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.9	5.70E-162	1453	100
gene0583	Chromosome	HI108	VFG000347(gb|NP_438870)	Hgp (VF0270)	Haemophilus influenzae Rd KW20	Mediates binding of both hemoglobin:haptoglobin complexes and free hemoglobin	Nonspecific virulence factor	Iron uptake system	44.9	5.10E-250	2217	100
gene0604	Chromosome	HI108	VFG002409(gb|NP_645079)	Type VII secretion system (VF0403)	Staphylococcus aureus subsp. aureus MW2	Plays a key role in promoting bacterial survival and the long-term persistence; play key roles in bacterial competitiveness	Offensive virulence factors	Secretion system	25.6	6.60E-18	215	44
gene0627	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	33.6	3.90E-19	220	100
gene0633	Chromosome	HI108	VFG010515(gb|YP_095205)	Dot/Icm (SS047)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	"Allows survival and growth in macrophages, prevent phagosome acidification and lysosome fusion, essential for induction of apoptosis in human macrophages"	Offensive virulence factors	Secretion system	35.2	1.10E-14	181	65
gene0647	Chromosome	HI108	VFG002197(gb|NP_814691)	BopD (VF0362)	Enterococcus faecalis V583	"Homologous to a sugar-binding transcriptional regulator involved in biofilm production; The actual role is unknown, but the association of enhanced biofilm formation in the presence of glucose and the possible involvement of a sugar-binding transcriptional regulator suggest a linkage to increased biofilm production in E. faecalis in the presence of specific carbohydrates"	-	-	30.8	5.00E-32	333	98.2
gene0654	Chromosome	HI108	VFG000907(gb|NP_755448)	alpha-Hemolysin (VF0225)	Escherichia coli CFT073	"Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1<beta> and TNF"	Offensive virulence factors	Toxin	27.5	8.30E-14	176	73.1
gene0655	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	29	2.00E-23	258	88.8
gene0683	Chromosome	HI108	VFG045345(gb|NP_797990)	MAM7 (VF0512)	Vibrio parahaemolyticus RIMD 2210633	Mediating attachment for the bacterium to a host cells	Offensive virulence factors	Adherence	33.1	2.50E-147	1331	99.2
gene0689	Chromosome	HI108	VFG001971(gb|NP_282584)	Capsule (VF0323)	Campylobacter jejuni subsp. jejuni NCTC 11168	Play an important role in bacterial survival and persistence in the environment and evasion of host immune response.The presence of heptose residues in the capsule may be important for virulence. Heptose residues found in some cell surface-located glycoconjugates are required for adhesion;	Offensive virulence factors;Defensive virulence factors	Adherence;Phase variation	48.5	1.60E-80	751	99
gene0694	Chromosome	HI108	VFG001443(gb|AAF37887)	OmpA (VF0236)	Escherichia coli O18:K1:H7 str. RS218	"Contributes to brain microvascular endothelial cells (BMECs) invasion via a ligand-receptor interaction. Interaction of OmpA with its receptor induces actin condensation at the binding site. The actin reorganization induced by E. coli depends on activation of several host proteins involved in signaling, including focal adhesion kinase, PI3-kinase, PKC, and caveolin-1.OmpA also binds to C4b-binding protein, to avoid complement-mediated attack;"	Offensive virulence factors;Defensive virulence factors	Invasion;Serum resistance	43.4	3.70E-20	230	41.2
gene0703	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	30.7	1.00E-35	365	83.8
gene0707	Chromosome	HI108	VFG013482(gb|NP_439837)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.9	2.30E-149	1344	97.8
gene0708	Chromosome	HI108	VFG013487(gb|NP_439838)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	96.9	3.20E-160	1438	100
gene0709	Chromosome	HI108	VFG013491(gb|NP_439839)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	96.9	8.50E-141	1270	100
gene0710	Chromosome	HI108	VFG013496(gb|NP_439840)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.3	5.00E-200	1782	100
gene0711	Chromosome	HI108	VFG013500(gb|NP_439841)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97.4	3.00E-177	1585	100
gene0712	Chromosome	HI108	VFG013503(gb|NP_439842)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.5	2.30E-217	1932	100
gene0719	Chromosome	HI108	VFG009810(gb|NP_215272)	PhoP/R (CVF331)	Mycobacterium tuberculosis H37Rv	-	Regulation of virulence-associated genes	Regulation	26.1	5.00E-19	222	69.6
gene0720	Chromosome	HI108	VFG001386(gb|NP_215271)	PhoP (VF0286)	Mycobacterium tuberculosis H37Rv	"Senses Mg2+ starvation, controls expression of genes involved in surface remodeling and adaptation to intracellular growth"	Regulation of virulence-associated genes	Regulation	34.7	3.00E-33	342	97.3
gene0729	Chromosome	HI108	VFG013508(gb|NP_439858)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99.2	3.80E-200	1783	100
gene0741	Chromosome	HI108	VFG001157(gb|AAC44560)	Hia/Hsf (VF0039)	Haemophilus influenzae C54	High-affinity adhesive activity and mediates interaction with a broad array of respiratory epithelial cell types; receptor unknown	Offensive virulence factors	Adherence	85.3	0	9371	86.6
gene0757	Chromosome	HI108	VFG001826(gb|NP_217099)	RelA (VF0287)	Mycobacterium tuberculosis H37Rv	Associated with stationary phase adaptation and long-term survival	Regulation of virulence-associated genes	Regulation	37.4	1.90E-126	1150	97.2
gene0761	Chromosome	HI108	VFG044332(gb|YP_002920252)	Ybt (VF0564)	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	The phenolate siderophore Ybt contributes to evasion of the activity of lipocalin2 in the lung ? a host factor which neutralizes enterobactin-based iron acquisition	Nonspecific virulence factor	Iron uptake system	29.9	5.40E-13	171	25.2
gene0796	Chromosome	HI108	VFG000907(gb|NP_755448)	alpha-Hemolysin (VF0225)	Escherichia coli CFT073	"Cytotoxic to many types of cells: erythrocytes, granulocytes, monocytes, endothelial cells and renal epithelial cells; stimulating the release of IL-1<beta> and TNF"	Offensive virulence factors	Toxin	21	2.50E-10	148	50.3
gene0811	Chromosome	HI108	VFG013236(gb|NP_438231)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98	1.90E-137	1241	99.2
gene0812	Chromosome	HI108	VFG013242(gb|NP_438232)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	94.9	2.80E-184	1646	100
gene0813	Chromosome	HI108	VFG013248(gb|NP_438233)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	92.7	3.10E-303	2674	100
gene0823	Chromosome	HI108	VFG037118(gb|NP_273782)	RecN (VF0457)	Neisseria meningitidis MC58	Recombinational repair protein that protects against ROS and non-oxidative killing by neutrophils	Defensive virulence factors	Stress protein	34.5	1.40E-79	745	99.6
gene0851	Chromosome	HI108	VFG001205(gb|NP_273677)	FbpABC (VF0272)	Neisseria meningitidis MC58	"Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein"	Nonspecific virulence factor	Iron uptake system	69.9	3.80E-125	1136	98.2
gene0852	Chromosome	HI108	VFG000249(gb|NP_273676)	FbpABC (VF0272)	Neisseria meningitidis MC58	"Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein"	Nonspecific virulence factor	Iron uptake system	71.2	4.10E-195	1741	99.8
gene0853	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	99.4	1.70E-203	1812	98.6
gene0860	Chromosome	HI108	VFG040705(gb|YP_067664)	TlyC (VF0489)	Rickettsia typhi str. Wilmington	Plays a role in phagosomal escape by rickettsiae	-	-	29.9	1.00E-21	245	53.8
gene0893	Chromosome	HI108	VFG001859(gb|YP_096662)	FeoAB (VF0160)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	A feoB mutant of L. pneumophila has a lowered Fe2+ uptake and is attenuated for intracellular growth	Nonspecific virulence factor	Iron uptake system	33.3	4.10E-06	111	16.9
gene0898	Chromosome	HI108	VFG000336(gb|NP_438308)	P2 protein (VF0042)	Haemophilus influenzae Rd KW20	P2 antigenic drift allows the organism to evade clearance by potentially protective antibodies and contributes to the development of chronic infection	Defensive virulence factors	Phase variation	97	1.30E-198	1770	100
gene0913	Chromosome	HI108	VFG011430(gb|NP_540392)	LPS (CVF383)	Brucella melitensis bv. 1 str. 16M	Plays a role in entry and early survival inside macrophages.Resistance to innate-immunity anti-bacterial responses.A modulator of the immune response;	-	-	64.7	1.30E-17	203	89.5
gene0914	Chromosome	HI108	VFG038840(gb|YP_008043465)	Polar flagella (VF0473)	Aeromonas hydrophila ML09-119	"Necessary for motility, adhesion and invasion; glycosylation of the flagellin may play a role in provoking a proinflammatory response"	Offensive virulence factors	Adherence	72.3	5.60E-94	866	98.3
gene0957	Chromosome	HI108	VFG013254(gb|NP_438368)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99.4	2.50E-190	1698	100
gene0980	Chromosome	HI108	VFG001231(gb|NP_249104)	Type IV pili (VF0082)	Pseudomonas aeruginosa PAO1	"Attaches to host cells, but not to mucin, causing a twitching motility that allows the bacteria to move along the cell surface; biofilm formation"	Offensive virulence factors	Adherence	31.3	6.20E-09	136	22.2
gene1015	Chromosome	HI108	VFG001149(gb|AAB03707)	Hap (VF0037)	Haemophilus influenzae N187	"Promote adherence and invasion, adhesive activity is localized within the Hap passenger domain; mediates bacterial aggregation and microcolony formation; Hap has serine protease activity"	Offensive virulence factors	Adherence	78.6	0	5478	100
gene1026	Chromosome	HI108	VFG013260(gb|NP_438427)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97.5	5.40E-165	1479	100
gene1027	Chromosome	HI108	VFG013265(gb|NP_438428)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97.9	2.00E-105	964	100
gene1028	Chromosome	HI108	VFG013271(gb|NP_438429)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97.5	3.60E-141	1273	100
gene1029	Chromosome	HI108	VFG013276(gb|NP_438430)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97.4	5.80E-201	1790	100
gene1030	Chromosome	HI108	VFG000348(gb|NP_438431)	HxuABC (VF0269)	Haemophilus influenzae Rd KW20	Using host heme-hemopexin as the source of heme iron for growth	Nonspecific virulence factor	Iron uptake system	93.9	0	3418	100
gene1031	Chromosome	HI108	VFG000341(gb|NP_438432)	HxuABC (VF0269)	Haemophilus influenzae Rd KW20	Using host heme-hemopexin as the source of heme iron for growth	Nonspecific virulence factor	Iron uptake system	97.5	0	2781	100
gene1032	Chromosome	HI108	VFG000340(gb|NP_438433)	HxuABC (VF0269)	Haemophilus influenzae Rd KW20	Using host heme-hemopexin as the source of heme iron for growth	Nonspecific virulence factor	Iron uptake system	86.1	0	3870	100
gene1110	Chromosome	HI108	VFG013281(gb|NP_438444)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97.8	0	2804	100
gene1118	Chromosome	HI108	VFG044235(gb|YP_856993)	amonabactin (IA020)	Aeromonas hydrophila subsp. hydrophila ATCC 7966	-	-	-	30.3	5.30E-23	256	59.3
gene1123	Chromosome	HI108	VFG000574(gb|NP_462662)	MgtBC (VF0106)	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	"MgtA and MgtB are not required for intracellular survival or for virulence, MgtC is essential for both functions"	Nonspecific virulence factor	Magnesium uptake system	27.4	8.80E-10	144	18.3
gene1130	Chromosome	HI108	VFG000515(gb|NP_460380)	TTSS(SPI-2 encode) (VF0321)	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	Secretes effector proteins to facilitate the replication of intracellular bacteria within membrane-bound Salmonella-containing vacuoles (SCVs)	Offensive virulence factors	Secretion system	31.6	1.50E-17	209	56.4
gene1132	Chromosome	HI108	VFG038436(gb|YP_008045208)	Tap type IV pili (VF0475)	Aeromonas hydrophila ML09-119	"The role of the Tap pilus remains to be elucidated, its biogenesis has strong implications in virulence in other ways. TapD, a prepilin peptidase is not only required for the processing of the prepilins before they are incorporated into the pilus filament but also for the processing of the pseudopilins of the T2SS, that are essential for the secretion of many virulence factors"	Offensive virulence factors	Adherence	30.6	1.70E-47	467	98.5
gene1133	Chromosome	HI108	VFG038431(gb|YP_858308)	Tap type IV pili (CVF783)	Aeromonas hydrophila subsp. hydrophila ATCC 7966	"The role of the Tap pilus remains to be elucidated, its biogenesis has strong implications in virulence in other ways. TapD, a prepilin peptidase is not only required for the processing of the prepilins before they are incorporated into the pilus filament but also for the processing of the pseudopilins of the T2SS, that are essential for the secretion of many virulence factors"	Offensive virulence factors	Adherence	38.3	3.20E-90	836	91.8
gene1134	Chromosome	HI108	VFG038429(gb|YP_008045206)	Tap type IV pili (VF0475)	Aeromonas hydrophila ML09-119	"The role of the Tap pilus remains to be elucidated, its biogenesis has strong implications in virulence in other ways. TapD, a prepilin peptidase is not only required for the processing of the prepilins before they are incorporated into the pilus filament but also for the processing of the pseudopilins of the T2SS, that are essential for the secretion of many virulence factors"	Offensive virulence factors	Adherence	41.2	7.40E-20	225	85.2
gene1136	Chromosome	HI108	VFG040705(gb|YP_067664)	TlyC (VF0489)	Rickettsia typhi str. Wilmington	Plays a role in phagosomal escape by rickettsiae	-	-	34.8	8.60E-28	296	75.3
gene1138	Chromosome	HI108	VFG045607(gb|YP_096929)	Dot/Icm (VF0156)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	"Allows survival and growth in macrophages, prevent phagosome acidification and lysosome fusion, essential for induction of apoptosis in human macrophages"	Offensive virulence factors	Secretion system	49.4	2.80E-56	541	99.2
gene1149	Chromosome	HI108	VFG039536(gb|NP_820549)	T4SS effectors (CVF803)	Coxiella burnetii RSA 493	Facilitates the translocation of many bacterial effector proteins across the bacterial and vacuole membranes to enter the host cytoplasm where the effector proteins mediate their specific activities to manipulate a variety of host cell processes	Offensive virulence factors	Secretion system	56.8	2.70E-75	705	98.4
gene1161	Chromosome	HI108	VFG000334(gb|NP_438494)	OapA (VF0040)	Haemophilus influenzae Rd KW20	"Required for efficient colonization of the nasopharynx, may play a minor role in adherence"	Offensive virulence factors	Adherence	94.4	1.70E-218	1942	100
gene1165	Chromosome	HI108	VFG001826(gb|NP_217099)	RelA (VF0287)	Mycobacterium tuberculosis H37Rv	Associated with stationary phase adaptation and long-term survival	Regulation of virulence-associated genes	Regulation	35.3	1.10E-127	1161	93.3
gene1182	Chromosome	HI108	VFG013286(gb|NP_438515)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99.4	2.00E-198	1768	100
gene1183	Chromosome	HI108	VFG013292(gb|NP_438516)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	100	3.70E-121	1101	71.6
gene1184	Chromosome	HI108	VFG001206(gb|NP_273675)	FbpABC (VF0272)	Neisseria meningitidis MC58	"Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein"	Nonspecific virulence factor	Iron uptake system	34.6	8.50E-26	278	85
gene1190	Chromosome	HI108	VFG037386(gb|YP_001847242)	Acinetobactin (VF0467)	Acinetobacter baumannii ACICU	High-affinity catechol-hydroxamate siderophore competing with host cells for iron	Nonspecific virulence factor	Iron uptake system	29.1	1.10E-22	252	75.8
gene1191	Chromosome	HI108	VFG002157(gb|NP_465372)	LpeA (VF0346)	Listeria monocytogenes EGD-e	A novel invasion favoring the entry of L. monocytogenes into nonprofessional phagocytes but not its invasion of macrophages	Offensive virulence factors	Invasion	38.7	7.90E-58	555	93.9
gene1211	Chromosome	HI108	VFG001931(gb|NP_282616)	CadF (VF0322)	Campylobacter jejuni subsp. jejuni NCTC 11168	"37 kDa outer-membrane protein mediating the binding of the organism to the extracellular matrix component fibronectin, which in turn stimulates a signal transduction pathway"	Offensive virulence factors	Adherence	32	3.50E-09	133	63.4
gene1220	Chromosome	HI108	VFG016058(gb|NP_251114)	pyoverdine (IA001)	Pseudomonas aeruginosa PAO1	Effective at acquiring iron from transferrin and lactoferrin.Cytotoxic due to its ability to stimulating the production of reactive oxygen species;	Nonspecific virulence factor	Iron uptake system	26.5	5.10E-29	309	90.2
gene1222	Chromosome	HI108	VFG032992(gb|NP_464816)	OatA (VF0441)	Listeria monocytogenes EGD-e	An Listeria peptidoglycan modifying enzyme that acetylates muramic acid residues of L. monocytogenes peptidoglycan critical for the bacterial survival in infected hosts	-	-	35.6	1.00E-38	393	57.4
gene1237	Chromosome	HI108	VFG037064(gb|NP_273631)	MntABC (VF0455)	Neisseria meningitidis MC58	Quenches ROS that is independent of superoxide dismutase and catalase	Defensive virulence factors	Stress protein	26.4	5.10E-16	194	97.3
gene1238	Chromosome	HI108	VFG037046(gb|NP_273632)	MntABC (VF0455)	Neisseria meningitidis MC58	Quenches ROS that is independent of superoxide dismutase and catalase	Defensive virulence factors	Stress protein	30.5	8.30E-22	244	77.2
gene1240	Chromosome	HI108	VFG001214(gb|NP_253237)	Type IV pili (VF0082)	Pseudomonas aeruginosa PAO1	"Attaches to host cells, but not to mucin, causing a twitching motility that allows the bacteria to move along the cell surface; biofilm formation"	Offensive virulence factors	Adherence	34.3	3.10E-44	438	94
gene1263	Chromosome	HI108	VFG038459(gb|YP_857681)	Tap type IV pili (CVF783)	Aeromonas hydrophila subsp. hydrophila ATCC 7966	"The role of the Tap pilus remains to be elucidated, its biogenesis has strong implications in virulence in other ways. TapD, a prepilin peptidase is not only required for the processing of the prepilins before they are incorporated into the pilus filament but also for the processing of the pseudopilins of the T2SS, that are essential for the secretion of many virulence factors"	Offensive virulence factors	Adherence	40.2	1.50E-76	718	88.8
gene1303	Chromosome	HI108	VFG038900(gb|YP_857314)	"Hemolysin, HlyA (CVF792)"	Aeromonas hydrophila subsp. hydrophila ATCC 7966	-	Offensive virulence factors	Toxin	50	8.40E-117	1065	99.3
gene1330	Chromosome	HI108	VFG000390(gb|NP_395174)	TTSS (VF0140)	Yersinia pestis CO92	"Deliver Yop effectors into the cytosol of host cells to disturb the dynamics of the cytoskeleton and block phagocytosis by macrophages and PMNs, also impair the production of pro-inflammatory cytokines, chemokines. These actions allow the survival of the invading Yersinia and their extracellular multiplication in lymphoid tissues"	Offensive virulence factors	Secretion system	29.8	1.30E-43	434	81.2
gene1332	Chromosome	HI108	VFG002144(gb|NP_220188)	TTSS (VF0344)	Chlamydia trachomatis D/UW-3/CX	"Translocating different effectors into the host cell, depending on the phase of the developmental cycle;"	Offensive virulence factors	Secretion system	27.7	1.30E-34	357	73.3
gene1342	Chromosome	HI108	VFG018241(gb|NP_230208)	AI-2 (VF0406)	Vibrio cholerae O1 biovar El Tor str. N16961	"LuxPQ receptor complex responds to the AI-2 molecule. Information from AI-2 is transduced through the LuxO protein to control the levels of the master transcription factor HapR. At low cell density, in the absence of autoinducers, HapR is not produced, so virulence factors are expressed and biofilms are formed. At high cell density, in the presence of autoinducers, LuxO is inactivated, HapR is produced, and it represses genes for virulence factor production and biofilm formation. These events are proposed to allow V. cholerae to leave the host, re-enter the environment in large numbers and initiate a new cycle of infection."	Regulation of virulence-associated genes	Regulation	74.1	2.10E-71	670	99.4
gene1350	Chromosome	HI108	VFG012509(gb|NP_753167)	Salmochelin siderophore (CVF456)	Escherichia coli CFT073	-	Nonspecific virulence factor	Iron uptake system	29.8	1.30E-15	193	43.4
gene1369	Chromosome	HI108	VFG013299(gb|NP_438681)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	96.5	7.30E-196	1746	100
gene1379	Chromosome	HI108	VFG002319(gb|YP_001006726)	Flagella (VF0394)	Yersinia enterocolitica subsp. enterocolitica 8081	"Required for efficient cellular invasion.; YplA, a phospholipase is secreted by this type III flagellum secretion system. YplA is required for survival of Y. enterocolitica in the Peyer's patches and for stimulation of the acute inflammatory response of the host to the infection."	Offensive virulence factors;Offensive virulence factors	Invasion;Secretion system	25	9.10E-11	152	31.3
gene1381	Chromosome	HI108	VFG000275(gb|NP_206867)	Urease (VF0050)	Helicobacter pylori 26695	"An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism"	-	-	29.5	1.80E-24	267	98.2
gene1382	Chromosome	HI108	VFG000274(gb|NP_206868)	Urease (VF0050)	Helicobacter pylori 26695	"An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism"	-	-	73.7	9.30E-85	786	93.8
gene1383	Chromosome	HI108	VFG000273(gb|NP_206869)	Urease (VF0050)	Helicobacter pylori 26695	"An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism"	-	-	31.2	5.20E-28	297	94
gene1385	Chromosome	HI108	VFG000270(gb|NP_206872)	Urease (VF0050)	Helicobacter pylori 26695	"An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism"	-	-	61.9	2.60E-206	1838	99.3
gene1386	Chromosome	HI108	VFG000269(gb|NP_206873)	Urease (VF0050)	Helicobacter pylori 26695	"An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism"	-	-	53.1	3.20E-27	287	97
gene1387	Chromosome	HI108	VFG000269(gb|NP_206873)	Urease (VF0050)	Helicobacter pylori 26695	"An important colonization factor, contributes to acid resistance, epithelial cell damage, chemotactic behavior, and nitrogen metabolism"	-	-	64	4.50E-29	303	99
gene1389	Chromosome	HI108	VFG001855(gb|YP_094724)	Hsp60 (VF0159)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	Mediate a complement-independent attachment to mammalian and amoebal host cells	Offensive virulence factors	Adherence	74.5	8.50E-223	1980	99.5
gene1395	Chromosome	HI108	VFG000333(gb|NP_438708)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	37.1	3.50E-39	394	90.6
gene1398	Chromosome	HI108	VFG000333(gb|NP_438708)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.7	7.10E-163	1461	100
gene1401	Chromosome	HI108	VFG048830(gb|YP_002920353.1)	Capsule (VF0560)	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	Assisting in evading the host immune system by protecting bacteria from opsonophagocytosis and serum killing	Defensive virulence factors	Antiphagocytosis	53.5	2.90E-142	1285	96.5
gene1412	Chromosome	HI108	VFG046610(gb|YP_169796.1)	Capsule (VF0543)	Francisella tularensis subsp. tularensis SCHU S4	Providing a stealth shield that prevents the host immune system from detecting this potent pathogen;	-	-	66.2	1.20E-79	742	99.1
gene1417	Chromosome	HI108	VFG049114(gb|YP_002918199.1)	Allantion utilization (VF0572)	Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044	Providing a nitrogen source to increase virulence in K. pneumoniae at certain sites of infection	-	-	25.2	3.10E-09	136	98.3
gene1425	Chromosome	HI108	VFG046465(gb|YP_169203.1)	EF-Tu (VF0460)	Francisella tularensis subsp. tularensis SCHU S4	Surface-expressed elongation factor-Tu (EF-Tu) mediates attachment by interacting with host cell nucleolin	Offensive virulence factors	Adherence	80.2	1.60E-191	1709	100
gene1475	Chromosome	HI108	VFG045346(gb|NP_933683)	IlpA (VF0513)	Vibrio vulnificus YJ016	Dual functions as an adhesin and an immunostimulant	Offensive virulence factors	Adherence	59	4.10E-85	790	99.3
gene1477	Chromosome	HI108	VFG001206(gb|NP_273675)	FbpABC (VF0272)	Neisseria meningitidis MC58	"Encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates, FbpA is the periplasmic Fe3+ binding protein"	Nonspecific virulence factor	Iron uptake system	34.6	3.50E-33	343	69.6
gene1478	Chromosome	HI108	VFG002552(gb|YP_109388)	Capsule I (VF0436)	Burkholderia pseudomallei K96243	A key virulence determinant and that loss of capsule production results in severe attenuation in animal models of disease	Defensive virulence factors	Antiphagocytosis	45.7	2.40E-36	368	81.5
gene1489	Chromosome	HI108	VFG000121(gb|NP_249453)	Alginate (VF0091)	Pseudomonas aeruginosa PAO1	"Allows the bacteria form biofilm; contributes to the persistence of the bacteria in the CF lung: act as an adhesin, preventing the bacteria from being expelled from the lung, and alginate slime layer makes it more difficult for phagocytes to ingest and kill the bacteria"	Defensive virulence factors;Defensive virulence factors	Antiphagocytosis;Serum resistance	61.6	7.30E-65	614	100
gene1491	Chromosome	HI108	VFG000135(gb|NP_249455)	Alginate (VF0091)	Pseudomonas aeruginosa PAO1	"Allows the bacteria form biofilm; contributes to the persistence of the bacteria in the CF lung: act as an adhesin, preventing the bacteria from being expelled from the lung, and alginate slime layer makes it more difficult for phagocytes to ingest and kill the bacteria"	Defensive virulence factors;Defensive virulence factors	Antiphagocytosis;Serum resistance	24.8	1.40E-23	260	95.9
gene1497	Chromosome	HI108	VFG046465(gb|YP_169203.1)	EF-Tu (VF0460)	Francisella tularensis subsp. tularensis SCHU S4	Surface-expressed elongation factor-Tu (EF-Tu) mediates attachment by interacting with host cell nucleolin	Offensive virulence factors	Adherence	80.2	1.60E-191	1709	100
gene1507	Chromosome	HI108	VFG047256(gb|YP_169432.1)	LPS (VF0542)	Francisella tularensis subsp. tularensis SCHU S4	"A key virulence factor does not signal through, and is not an agonist of, toll like receptor 4 (TLR-4) and has little endotoxic activity"	-	-	50.3	3.20E-130	1181	98.7
gene1514	Chromosome	HI108	VFG000575(gb|NP_462663)	MgtBC (VF0106)	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	"MgtA and MgtB are not required for intracellular survival or for virulence, MgtC is essential for both functions"	Nonspecific virulence factor	Magnesium uptake system	39.8	2.10E-16	197	55.5
gene1519	Chromosome	HI108	VFG000320(gb|NP_208266)	LPS (VF0056)	Helicobacter pylori 26695	"H. pylori LPS have much lower immunobiological activities than enterobacterial LPS, thus may prolong H. pylori infection for longer.Mediates a lectin-like interaction with laminin, the binding may disrupt epithelial cell-basement membrane interactions contributing to the disruption of gastric mucosal integrity and the development of gastric leakiness associated with the bacterium"	Offensive virulence factors	Adherence	47.3	2.80E-38	384	93.6
gene1520	Chromosome	HI108	VFG000330(gb|NP_438812)	LOS (VF0044)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	96.5	4.90E-242	2145	100
gene1521	Chromosome	HI108	VFG013315(gb|NP_438813)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	100	1.30E-149	1346	100
gene1527	Chromosome	HI108	VFG002563(gb|YP_109399)	Capsule I (VF0436)	Burkholderia pseudomallei K96243	A key virulence determinant and that loss of capsule production results in severe attenuation in animal models of disease	Defensive virulence factors	Antiphagocytosis	27.2	1.90E-11	158	28.5
gene1529	Chromosome	HI108	VFG045329(gb|AAB36696)	HhuA (VF0271)	Haemophilus influenzae TN106	"Similar to HgpA, mediates binding of both hemoglobin:haptoglobin complexes and free hemoglobin"	Nonspecific virulence factor	Iron uptake system	51.1	1.10E-161	1454	79.5
gene1530	Chromosome	HI108	VFG000347(gb|NP_438870)	Hgp (VF0270)	Haemophilus influenzae Rd KW20	Mediates binding of both hemoglobin:haptoglobin complexes and free hemoglobin	Nonspecific virulence factor	Iron uptake system	79.2	1.30E-24	264	84.4
gene1531	Chromosome	HI108	VFG013248(gb|NP_438233)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	26.2	1.70E-40	408	93.1
gene1532	Chromosome	HI108	VFG000365(gb|NP_405474)	Yersiniabactin (VF0136)	Yersinia pestis CO92	"FyuA/Psn-Irp system uses yersiniabactin, a siderophore that can remove iron from a number of mammalian proteins, due to its extremely high affinity for ferric iron"	Nonspecific virulence factor	Iron uptake system	27	1.30E-45	452	97.8
gene1541	Chromosome	HI108	VFG000700(gb|AAP42192)	Capsule (VF0043)	Haemophilus influenzae str. 1007	-	-	-	33.6	1.20E-26	285	94.2
gene1582	Chromosome	HI108	VFG000347(gb|NP_438870)	Hgp (VF0270)	Haemophilus influenzae Rd KW20	Mediates binding of both hemoglobin:haptoglobin complexes and free hemoglobin	Nonspecific virulence factor	Iron uptake system	82.5	0	4614	100
gene1584	Chromosome	HI108	VFG000077(gb|NP_465991)	ClpP (VF0074)	Listeria monocytogenes EGD-e	Serine protease involved in proteolysis and is required for growth under stress conditions	Defensive virulence factors	Stress protein	61.1	5.50E-68	641	100
gene1601	Chromosome	HI108	VFG004125(gb|NP_460113)	curli fibers/thin aggregative fimbriae (AGF) (AI094)	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	-	-	-	32.4	1.10E-08	130	47.1
gene1610	Chromosome	HI108	VFG013321(gb|NP_438894)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.7	1.70E-135	1224	100
gene1617	Chromosome	HI108	VFG013327(gb|NP_438900)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.9	0	2823	100
gene1641	Chromosome	HI108	VFG013342(gb|NP_438924)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	97.5	5.40E-157	1410	100
gene1645	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	30.2	1.50E-24	267	98.2
gene1690	Chromosome	HI108	VFG013346(gb|NP_438972)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	99.3	3.90E-166	1489	100
gene1701	Chromosome	HI108	VFG000344(gb|NP_438273)	HitABC (VF0268)	Haemophilus influenzae Rd KW20	hitABC(fbpABC) operon encodes a periplasmic-binding protein-dependent iron transport system necessary for the utilization of iron bound to transferrin or iron chelates	Nonspecific virulence factor	Iron uptake system	26.5	3.50E-13	172	44.1
gene1715	Chromosome	HI108	VFG001386(gb|NP_215271)	PhoP (VF0286)	Mycobacterium tuberculosis H37Rv	"Senses Mg2+ starvation, controls expression of genes involved in surface remodeling and adaptation to intracellular growth"	Regulation of virulence-associated genes	Regulation	34.1	1.60E-26	284	98.7
gene1736	Chromosome	HI108	VFG000079(gb|NP_463763)	ClpC (VF0072)	Listeria monocytogenes EGD-e	"An ATPase promoting early escape form the phagosome of macrophages; ClpC is also required for adhesion and invasion, possibly by modulating the expression of InlA,InlB and ActA"	Defensive virulence factors	Stress protein	43.4	5.10E-182	1630	100
gene1744	Chromosome	HI108	VFG013352(gb|NP_439027)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	100	3.80E-86	797	100
gene1745	Chromosome	HI108	VFG013354(gb|NP_439028)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	100	2.80E-141	1274	100
gene1746	Chromosome	HI108	VFG013357(gb|NP_439029)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	91.2	1.50E-91	846	59.9
gene1748	Chromosome	HI108	VFG013361(gb|NP_439032)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	58	5.20E-97	893	99.3
gene1749	Chromosome	HI108	VFG013365(gb|NP_439033)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	90.3	9.80E-252	2229	100
gene1750	Chromosome	HI108	VFG013368(gb|NP_439034)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	90.1	5.20E-183	1635	100
gene1761	Chromosome	HI108	VFG038219(gb|YP_001845364)	BfmRS (VF0463)	Acinetobacter baumannii ACICU	"Controls biofilm formation and cellular morphology; participates in cell adhesion, resistance to serum killing and antibiotic susceptibility"	Regulation of virulence-associated genes	Regulation	33.8	1.70E-31	327	96.6
gene1771	Chromosome	HI108	VFG036974(gb|NP_274719)	MtrCDE (VF0451)	Neisseria meningitidis MC58	"A tripartite multidrug efflux pump essential for resistance to <beta>-lactams (penicillin G and nafcillin), macrolides (erythromycin), and host-derived compounds (peptide LL-37 and progesterone and essential for growth of gonococci in the lower genital tract of experimentally infected female mice"	-	-	29.1	1.50E-19	226	64.6
gene1772	Chromosome	HI108	VFG037720(gb|YP_001847164)	AdeFGH efflux pump (VF0504)	Acinetobacter baumannii ACICU	Play a potential role in the synthesis and transport of autoinducer molecules during biofilm formation	-	-	31.3	3.90E-128	1166	98.5
gene1774	Chromosome	HI108	VFG036956(gb|NP_273368)	FarAB (VF0450)	Neisseria meningitidis MC58	Mediates the resistance to antimicrobial long-chain fatty acids	-	-	57.3	9.50E-168	1505	97.8
gene1775	Chromosome	HI108	VFG036938(gb|NP_273367)	FarAB (VF0450)	Neisseria meningitidis MC58	Mediates the resistance to antimicrobial long-chain fatty acids	-	-	45.6	5.30E-78	730	96.9
gene1791	Chromosome	HI108	VFG013374(gb|NP_439075)	LOS (CVF494)	Haemophilus influenzae Rd KW20	Major immunogen.LOS phosphorylcholine (ChoP) may influence invasion via interaction with PAF receptor and stimulates of inflammatory signals.LPS phase variation is characterized by the spontaneous loss and gain of oligosaccharide structures present in the outer core. the phase variable expression of LPS biosynthesis genes promotes evasion of antigen-specific host immune defences and allow colonization of different host microenvironments;	-	-	98.5	5.30E-191	1704	100
gene1794	Chromosome	HI108	VFG015000(gb|NP_252339)	Alginate regulation (CVF523)	Pseudomonas aeruginosa PAO1	-	Defensive virulence factors	Antiphagocytosis	41.6	6.90E-98	902	100
gene1795	Chromosome	HI108	VFG002189(gb|NP_816140)	Capsule (VF0361)	Enterococcus faecalis V583	Contributes to host immune evasion;	Defensive virulence factors	Antiphagocytosis	29.6	1.00E-25	278	96.2
gene1796	Chromosome	HI108	VFG002190(gb|NP_816141)	Capsule (VF0361)	Enterococcus faecalis V583	Contributes to host immune evasion;	Defensive virulence factors	Antiphagocytosis	47.5	1.40E-57	552	97.1
gene1809	Chromosome	HI108	VFG037028(gb|NP_273273)	KatA (VF0454)	Neisseria meningitidis MC58	"Detoxifies H2O2; Protects against ROS (Reactive oxygen species), a family of chemical that are oxidized version of molecular oxygen, including hydrogen peroxide, superoxide and hydroxyl radicals"	Defensive virulence factors	Stress protein	91.9	2.20E-289	2554	99.8
gene1817	Chromosome	HI108	VFG010882(gb|YP_094896)	Cytochrome c maturation (ccm) locus (CVF358)	Legionella pneumophila subsp. pneumophila str. Philadelphia 1	-	Nonspecific virulence factor	Iron uptake system	39.3	8.90E-123	1118	98.6
gene1826	Chromosome	HI108	VFG014984(gb|NP_253136)	Alginate regulation (CVF523)	Pseudomonas aeruginosa PAO1	-	Defensive virulence factors	Antiphagocytosis	42.2	3.10E-58	559	85
gene1831	Chromosome	HI108	VFG016046(gb|NP_251103)	pyoverdine (IA001)	Pseudomonas aeruginosa PAO1	Effective at acquiring iron from transferrin and lactoferrin.Cytotoxic due to its ability to stimulating the production of reactive oxygen species;	Nonspecific virulence factor	Iron uptake system	53.3	1.80E-138	1252	96.3
gene1853	Chromosome	HI108	VFG047708(gb|YP_170571.1)	Pyrimidine biosynthesis (VF0558)	Francisella tularensis subsp. tularensis SCHU S4	Mediating bacterial resistance to reactive oxygen species (ROS) that is important for phagosomal escape	-	-	22.1	6.50E-11	152	50.9
gene1872	Chromosome	HI108	VFG000337(gb|NP_439153)	IgA1 protease (VF0045)	Haemophilus influenzae Rd KW20	Interferes with the barrier functions of mucosal IgA antibodies by cleaving secretory IgA1 in the hinge region.Phagosomal escape ?	Defensive virulence factors	Ig protease	80.8	0	5105	83.1