Back to Journals » OncoTargets and Therapy » Volume 13

Genetic and Clinical Characterization of HOXB2 in Glioma

Authors Pan X, Liu W, Chai Y, Wang J, Zhang Y

Received 23 June 2020

Accepted for publication 5 October 2020

Published 14 October 2020 Volume 2020:13 Pages 10465—10473

DOI https://doi.org/10.2147/OTT.S268635

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Takuya Aoki


Xin Pan,1,2,* Wei Liu,1,2,* Yi Chai,1,2,* Junhua Wang,1,2 Yuqi Zhang1,2

1Department of Neurosurgery, Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing 100040, People’s Republic of China; 2School of Clinical Medicine, Tsinghua University, Beijing 10084, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yuqi Zhang
School of Clinical Medicine, Tsinghua University, No. 1, Tsinghua Yuan, Handian District, Beijing 10084, People’s Republic of China
Email doctorzyq@126.com

Background: Glioma is a highly aggressive and heterogeneous cancer with poor survival rates. Homeobox (HOX) genes are transcription factors that play pivotal roles in many aspects of cellular physiology, embryonic development, and tissue homeostasis. Mutations in HOX genes can lead to increased cancer predisposition. Abnormal expression of HOXB2 may result in the development and progression of tumors. However, its prognostic value and mechanism of dysregulation remain unclear.
Methods: The present study included 1001 glioma patients. The correlations between the expression of HOXB2 and subgroups of glioma were investigated by t-test analyses. The prognostic value of HOXB2 was explored by Kaplan–Meier analysis as well as univariate and multivariate Cox analyses. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were employed to detect the biological function of HOXB2 in glioma. CCK-8 and transwell assays were performed to determine the role of HOXB2 in cell proliferation and invasion.
Results: HOXB2 was positively correlated with tumor grade and enriched in patients with isocitrate dehydrogenase 1 wild-type and age > 41 years. HOXB2 was identified as an independent prognostic biomarker in glioma patients. HOXB2 was associated with cell invasion and promoted the proliferation of glioma cells in vitro.
Conclusion: HOXB2 is an independent prognostic factor and contributes to tumor invasion in glioma patients.

Keywords: glioma, gene expression, neoplasm invasiveness, prognosis, HOXB2

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]