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Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia

Authors Dietrich-Muszalska A, Kwiatkowska A

Received 3 January 2014

Accepted for publication 4 March 2014

Published 5 May 2014 Volume 2014:10 Pages 703—709

DOI https://doi.org/10.2147/NDT.S60034

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Anna Dietrich-Muszalska, Anna Kwiatkowska

Department of Biological Psychiatry of the Chair of Experimental and Clinical Physiology, Medical University of Lodz, Lodz, Poland

Abstract: Blood platelets are considered to be a peripheral marker in schizophrenia and other psychiatric disorders. Oxidative stress in schizophrenia may be responsible for changes in platelet metabolism and function; therefore, the aim of this study was to examine and compare the generation of superoxide anions and activity of an antioxidant enzyme (glutathione peroxidase [GPx]) in blood platelets in patients with schizophrenia and healthy subjects. The level of superoxide anions generated in platelets after thrombin and platelet-activating factor stimulation and activity of GPx in patients with schizophrenia and healthy volunteers was estimated. The results obtained from the study indicate that the generation of superoxide anions in platelets as a response of platelets in patients with schizophrenia to such activating factors as thrombin or platelet-activating factor is higher than in the response of platelets of healthy subjects. In platelets from schizophrenic patients, suppressed GPx activity of about 67% was observed.

Keywords: schizophrenia, blood platelet, superoxide anion, activating factors, glutathione peroxidase

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