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Gemcitabine-loaded liposomes: rationale, potentialities and future perspectives

Authors Federico C, Morittu VM, Britti D, Trapasso E, Cosco D

Received 19 May 2012

Accepted for publication 21 June 2012

Published 1 November 2012 Volume 2012:7 Pages 5423—5436

DOI https://doi.org/10.2147/IJN.S34025

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Cinzia Federico, Valeria M Morittu, Domenico Britti, Elena Trapasso, Donato Cosco

Department of Health Sciences, Building of BioSciences, University “Magna Græcia” of Catanzaro, Campus Universitario “S Venuta”, Germaneto, Italy

Abstract: This review describes the strategies used in recent years to improve the biopharmaceutical properties of gemcitabine, a nucleoside analog deoxycytidine antimetabolite characterized by activity against many kinds of tumors, by means of liposomal devices. The main limitation of using this active compound is the rapid inactivation of deoxycytidine deaminase following administration in vivo. Consequently, different strategies based on its encapsulation/complexation in innovative vesicular colloidal carriers have been investigated, with interesting results in terms of increased pharmacological activity, plasma half-life, and tumor localization, in addition to decreased side effects. This review focuses on the specific approaches used, based on the encapsulation of gemcitabine in liposomes, with particular attention to the results obtained during the last 5 years. These approaches represent a valid starting point in the attempt to obtain a novel, commercializable drug formulation as already achieved for liposomal doxorubicin (Doxil®, Caelyx®).

Keywords: gemcitabine, liposomes, multidrug, poly(ethylene glycol), tumors

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