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Gastroparesis: a review of current and emerging treatment options

Authors Enweluzo C, Aziz F

Received 20 June 2013

Accepted for publication 5 August 2013

Published 5 September 2013 Volume 2013:6 Pages 161—165


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 7

Chijioke Enweluzo, Fahad Aziz

Hospital Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA

Abstract: Gastroparesis is a motility disorder of the stomach causing delay in food emptying from the stomach without any evidence of mechanical obstruction. The majority of cases are idiopathic. Patients need to be diagnosed properly by formal testing, and the evaluation of the severity of the gastroparesis may assist in guiding therapy. Initially, dietary modifications are encouraged, which include frequent and small semisolid-based meals. Promotility medications, like erythromycin, and antiemetics, like prochlorperazine, are offered for symptom relief. In patients who are refractory to pharmacologic treatment, more invasive options, such as intrapyloric botulinum toxin injections, placement of a jejunostomy tube, or implantation of a gastric stimulator, can be considered. Hemin therapy and gastric electric stimulation are emerging treatment options that are still at different stages of research. Regenerative medicine and stem cell-based therapies also hold promise for gastroparesis in the near future.

Keywords: Gastroparesis, gastric emptying, gastric electrical stimulation, hemin

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