Gastric and colon metastasis from breast cancer: case report, review of the literature, and possible underlying mechanisms
Authors Villa Guzmán JC, Espinosa J, Cervera R, Delgado M, Patón R, Cordero García JM
Received 18 December 2014
Accepted for publication 7 April 2015
Published 23 December 2016 Volume 2017:9 Pages 1—7
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Pranela Rameshwar
J Carlos Villa Guzmán,1 J Espinosa,1 R Cervera,1 M Delgado,2 R Patón,3 JM Cordero García4
1Department of Medical Oncology, 2Department of Pathology, 3Department of Gastroenterology, 4Department of Nuclear Medicine, University Ciudad Real General Hospital, Ciudad Real, Spain
Abstract: Gastrointestinal metastases from breast cancer are not common. We present a 58-year-old female diagnosed with lobular breast cancer some years before whose relapses were gastric and colonic mucosal. Simultaneous metastases are extremely rare. To our knowledge, no cases of initial dual affectation have been reported. The patient also showed gastritis by Helicobacter pylori. Invasive lobular breast carcinoma is the most frequent special type of breast cancer and carries some specific molecular alterations such as loss of expression of E-cadherin. Although underlying mechanisms of metastasization are not entirely known, chemokines as well as inflammatory events seem to be implicated in this process. Interaction between chemokines and their receptors frequently induces cell migration. We hypothesize that H. pylori, inflammatory cells, and chemokines may create a favorable environment attracting tumor cells.
Keywords: chemokines, gastrointestinal metastases, H. pylori, lobular carcinoma
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