Back to Browse Journals » Open Access Surgery » Volume 1

Gamma knife radiosurgery for uveal melanoma ineligible for brachytherapy by the Collaborative Ocular Melanoma Study criteria

Authors Nicola G Ghazi, Christopher S Ketcherside, Jason Sheehan, Brian P Conway

Published 30 September 2008 Volume 2008:1 Pages 21—24


Review by Single-blind

Peer reviewer comments 5

Nicola G Ghazi1, Christopher S Ketcherside1, Jason Sheehan2, Brian P Conway1

1Department of Ophthalmology and 2Neurosurgery, University of Virginia Health System, Charlottesville, VA, USA

Purpose: To report outcomes of Gamma Knife radiosurgery (GKRS) in treating uveal melanoma lesions ineligible for standard brachytherapy.

Methods: A retrospective interventional case series of uveal melanoma patients treated with GKRS between 1996 and 2004 was performed. The main outcome measures were local tumor control, metastasis, and death.

Results: Four patients with uveal melanoma treated with GKS were identified. Three tumors involved the ciliary body and one was macular with its border within 2 mm of the optic disc. Adequate globe stabilization was achieved by retrobulbar anesthesia in all cases. Pretreatment mean visual acuity was 20/30. Tumor volume as determined by magnetic resonance imaging ranged from 0.05 to 0.30 cc. Ultrasonographic greatest tumor diameter and height ranged from 11 to 18 mm (mean 14.5 mm) and 2.9 to 4.5 mm (mean 3.6 mm), respectively. The peripheral dose varied from 16.5 to 30 Gray. Local tumor control was achieved in all cases over a follow up period of 6 to 96 months. Mean final visual acuity was 20/50. One eye was enucleated for neovascular glaucoma and one patient died from liver and lung metastasis.

Conclusions: GKRS for uveal melanoma appears to be safe and effective. The metastasis and mortality rates appear to be comparable to those following brachytherapy and enucleation. Moreover, local tumor control and enucleation rates are similar to those following brachytherapy. The findings in this small series suggest a role for GKRS in the treatment of selected cases of uveal melanomas.

Keywords: gamma knife radiosurgery, radiation therapy, uveal melanoma

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF] 


Other article by this author:

Is reduction in the risk of vision loss the only benefit of photodynamic therapy in predominantly classic subfoveal choroidal neovascularization?

Nicola G Ghazi, Brian P Conway, James S Tiedeman, Steven J Yoon

Clinical Ophthalmology 2008, 2:773-780

Published Date: 5 December 2008

Readers of this article also read:

Effects of irbesartan on serum uric acid levels in patients with hypertension and diabetes

Nakamura M, Sasai N, Hisatome I, Ichida K

Clinical Pharmacology: Advances and Applications 2014, 6:79-86

Published Date: 3 May 2014

Considerations for ceramic inlays in posterior teeth: a review

Hopp CD, Land MF

Clinical, Cosmetic and Investigational Dentistry 2013, 5:21-32

Published Date: 18 April 2013

Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering

Lai JY, Li YT, Cho CH, Yu TC

International Journal of Nanomedicine 2012, 7:1101-1114

Published Date: 23 February 2012

Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation

Sha X, Wu J, Chen Y, Fang X

International Journal of Nanomedicine 2012, 7:705-712

Published Date: 10 February 2012

Serratia pneumonia presenting as hemoptysis in a patient with sarcoidosis: a case report

Zarogoulidis P, Porpodis K, Konoglou M, Saroglou M, Mitrakas A, Matthaios D, Touzopoulos P, Archontogeorgis K, Koulelidis A, Zarogoulidis K, Tryfon S

International Journal of General Medicine 2011, 4:661-664

Published Date: 8 September 2011

Noninvasively characterizing the different αvβ3 expression patterns in lung cancers with RGD-USPIO using a clinical 3.0T MR scanner

Tao Jiang, Chunfu Zhang, Xuan Zheng, et al

International Journal of Nanomedicine 2009, 4:241-249

Published Date: 12 November 2009

Synergistic effect of magnetic nanoparticles of Fe3O4 with gambogic acid on apoptosis of K562 leukemia cells

Baoan Chen, Yiqiong Liang, Weiwei Wu, et al

International Journal of Nanomedicine 2009, 4:251-259

Published Date: 10 November 2009

Daunorubicin-loaded magnetic nanoparticles of Fe3O4 overcome multidrug resistance and induce apoptosis of K562-n/VCR cells in vivo

Bao-an Chen, Bin-bin Lai, Jian Cheng, et al

International Journal of Nanomedicine 2009, 4:201-208

Published Date: 23 September 2009

A gene expression ratio-based diagnostic test for bladder cancer

Lingsheng Dong, Andrew J Bard, William G Richards, Matthew D Nitz, Dan Theodorescu, et al

Advances and Applications in Bioinformatics and Chemistry 2009, 2:17-22

Published Date: 12 January 2009