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Functionalized carbon nanotubes: biomedical applications

Authors Vardharajula S, Ali, Tiwari P, Eroğlu E, Komal Vig, Dennis V, Shree S

Received 11 July 2012

Accepted for publication 22 August 2012

Published 9 October 2012 Volume 2012:7 Pages 5361—5374

DOI https://doi.org/10.2147/IJN.S35832

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Sandhya Vardharajula,1 Sk Z Ali,2 Pooja M Tiwari,1 Erdal Eroğlu,1 Komal Vig,1 Vida A Dennis,1 Shree R Singh1

1Center for NanoBiotechnology and Life Sciences Research, Alabama State University, Montgomery, AL, USA; 2Department of Microbiology, Osmania University, Hyderabad, India

Abstract: Carbon nanotubes (CNTs) are emerging as novel nanomaterials for various biomedical applications. CNTs can be used to deliver a variety of therapeutic agents, including biomolecules, to the target disease sites. In addition, their unparalleled optical and electrical properties make them excellent candidates for bioimaging and other biomedical applications. However, the high cytotoxicity of CNTs limits their use in humans and many biological systems. The biocompatibility and low cytotoxicity of CNTs are attributed to size, dose, duration, testing systems, and surface functionalization. The functionalization of CNTs improves their solubility and biocompatibility and alters their cellular interaction pathways, resulting in much-reduced cytotoxic effects. Functionalized CNTs are promising novel materials for a variety of biomedical applications. These potential applications are particularly enhanced by their ability to penetrate biological membranes with relatively low cytotoxicity. This review is directed towards the overview of CNTs and their functionalization for biomedical applications with minimal cytotoxicity.

Keywords: carbon nanotubes, cytotoxicity, functionalization, biomedical applications

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