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Function of microRNA-145 and mechanisms underlying its role in malignant tumor diagnosis and treatment

Authors Ye D, Shen ZS, Zhou SH

Received 22 October 2018

Accepted for publication 28 December 2018

Published 22 January 2019 Volume 2019:11 Pages 969—979

DOI https://doi.org/10.2147/CMAR.S191696

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Lu-Zhe Sun


Dong Ye,1,2 Zhisen Shen,2 Shuihong Zhou1

1Department of Otorhinolaryngology – Head and Neck Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; 2Department of Otorhinolaryngology –Head and Neck Surgery, Lihuili Hospital, Ningbo University, Ningbo, Zhejiang, China

Abstract: miRNAs are single-stranded small RNAs that do not encode proteins. They can combine complementarily with the 3’-UTRs of target gene mRNA molecules to promote targeted mRNA degradation or inhibit mRNA translation, thereby regulating gene expression at the post-transcriptional level. MiRNAs participate in regulation of cell cycling, growth, apoptosis, differentiation, and stress responses. MiRNA-145 (miR-145) is a tumor suppressor that targets various tumor-specific genes and proteins, thereby influencing related signaling pathways. MiR-145 not only regulates tumor growth, invasion, and metastasis, but is also important for tumor angiogenesis and tumor stem cell proliferation. Here, we review the roles and mechanisms of miR-145 in the diagnosis and treatment of malignant tumors. Published data confirm that miR-145 expression in various tumors is significantly lower than that in normal tissues and that overexpression of miR-145 inhibits the growth of different tumor cells, significantly reduces the ability of tumors to spread, and improves sensitivity to chemotherapeutic drugs. We conclude that miR-145 is a potential marker for use in the early diagnosis and prognostic evaluation of patients with cancer, has a role as a tumor suppressor, and is a promising cancer treatment target candidate.

Keywords: miRNA-145, tumor, proliferation, metastasis, mechanism

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