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Fulminate anaerobic bacteremia after chemotherapy for metastatic breast cancer despite the prophylactic use of GCSF

Authors Petrova M, Mihaylova Z, Fakirova A

Published 13 April 2010 Volume 2010:3 Pages 35—37


Review by Single anonymous peer review

Peer reviewer comments 2

Mila Petrova1, Zhasmina Mihaylova1, Albena Fakirova2

1Clinic of Hematology and Oncology, Department of Medical Oncology; 2Department of Pathology, Medical Military Academy, Sofia, Bulgaria

Abstract: Chemotherapy-induced neutropenia often occurs in our routine work and presents an obstacle for adequate (dose and continuance) treatment, which may affect patients’ outcome. Granulocyte colony-stimulating factors (GCSFs) effectively prevent myelosuppression and thus improve the standard treatment. Through their application cases of chemotherapyinduced neutropenia have been reduced. Still these factors cannot remove entirely the danger of encountering neutropenia, which can cause dangerous complications. We present a case of a fulminate anaerobic infection with unknown origin in a patient with metastatic breast cancer after standard treatment with chemotherapy supported by GCSFs.

Keywords: neutropenia, granulocyte colony-stimulating factors, anaerobic infection, phlegmon

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