Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 13

Frontal Fibrosing Alopecia. An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin?

Authors Noakes R

Received 14 May 2020

Accepted for publication 8 July 2020

Published 27 July 2020 Volume 2020:13 Pages 479—484

DOI https://doi.org/10.2147/CCID.S262803

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Jeffrey Weinberg


Rowland Noakes

Queensland Institute of Dermatology, South Brisbane, Queensland, Australia

Correspondence: Rowland Noakes
Queensland Institute of Dermatology, 10 Browning Street, South Brisbane, Queensland, Australia
Tel +61 7 33294400
Fax +61 7 3329 4455
Email ky_n_urenine@hotmail.com.au

Abstract: Sun protection has been recommended by public health authorities to reduce the risk of keratinocyte and melanocyte tumors, yet some sun exposure is required for vitamin D synthesis. Frontal fibrosing alopecia (FFA) is a cicatricial alopecia that has been reported to have an association with facial photoprotection. The brief review proposes the hypothesis that FFA arises as a result of excessive facial photo-protection with a resultant disturbance in immunological homeostasis mediated via the aryl hydrocarbon receptor-kynurenine pathway axis (AHR/KP) leading to the collapse of immune privilege at the hair bulge.

Keywords: sun exposure, aryl hydrocarbon receptor, frontal fibrosing alopecia, 6-formylindolo [3, 2-b]carbazole

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]