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Innovation of natural essential oil-loaded Orabase for local treatment of oral candidiasis

Authors Labib G, Aldawsari H

Received 24 March 2015

Accepted for publication 2 May 2015

Published 29 June 2015 Volume 2015:9 Pages 3349—3359

DOI https://doi.org/10.2147/DDDT.S85356

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Shu-Feng Zhou


Gihan S Labib,1,2 Hibah Aldawsari1

1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Purpose: Oral candidiasis may be manifested in the oral cavity as either mild or severe oral fungal infection. This infection results from the overgrowth of Candida species normally existing in the oral cavity in minute amounts based on many predisposing factors. Several aspects have spurred the search for new strategies in the treatment of oral candidiasis, among which are the limited numbers of new antifungal drugs developed in recent years. Previous studies have shown that thyme and clove oils have antimycotic activities and have suggested their incorporation into pharmaceutical preparations. This study aimed to investigate the possibility of the incorporation and characterization of essential oils or their extracted active ingredients in Orabase formulations.
Methods: Orabase loaded with clove oil, thyme oil, eugenol, and thymol were prepared and evaluated for their antifungal activities, pH, viscosity, erosion and water uptake characteristics, mechanical properties, in vitro release behavior, and ex vivo mucoadhesion properties.
Results: All prepared bases showed considerable antifungal activity and acceptable physical characteristics. The release pattern from loaded bases was considerably slow for all oils and active ingredients. All bases showed appreciable adhesion in the in vitro and ex vivo studies.
Conclusion: The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients’ well-being.

Keywords: antifungal activity, clove oil, eugenol, mucoadhesion, oral gel, thyme oil, thymol

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