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Efficiency and safety of subconjunctival injection of anti-VEGF agent – bevacizumab – in treating dry eye

Authors Jiang X, Lv H, Qiu W, Liu Z, Li X, Wang W

Received 26 March 2015

Accepted for publication 22 April 2015

Published 12 June 2015 Volume 2015:9 Pages 3043—3050


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Shu-Feng Zhou

Xiaodan Jiang,* Huibin Lv,* Weiqiang Qiu, Ziyuan Liu, Xuemin Li, Wei Wang

Department of Ophthalmology, Peking University Third Hospital, Beijing, People’s Republic of China

*These authors contributed equally as first authors

Purpose: Dry eye is a chronic inflammatory ocular surface disease with high prevalence. The current therapies for dry eye remain to be unspecific and notcomprehensive. This study aims to explore safety and efficacy of a novel treatment – subconjunctival injection of bevacizumab – in dry eye patients.
Methods: Sixty-four eyes of 32 dry eye patients received subconjunctival injection of 100 μL 25 mg/mL bevacizumab. Dry eye symptoms, signs (corrected visual acuity, intraocular pressure, conjunctival vascularity, corneal staining, tear break-up time, Marx line score, and blood pressure), and conjunctival impression cytology were evaluated 3 days before and 1 week, 1 month, and 3 months after injection.
Results: Significant improvements were observed in dry eye symptoms, tear break-up time, and conjunctival vascularization area at all the visits after injection compared to the baseline (P<0.05). The density of the goblet cell increased significantly at 1 month and 3 months after injection (P<0.05). There was no visual and systemic threat observed in any patient.
Conclusion: Subconjunctival injection of 100 µL 25 mg/mL bevacizumab is a safe and efficient treatment for ocular surface inflammation of dry eye disease.

Keywords: anti-VEGF, bevacizumab, dry eye, ocular surface inflammation, subconjunctival

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