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Drug Design, Development and Therapy


Archive: Volume 15, 2021

Bitter Taste Receptor as a Therapeutic Target in Orthopaedic Disorders

Cheng W, Yao M, Liu F

Drug Design, Development and Therapy 2021, 15:895-903

Published Date: 26 February 2021

Low Frequency of Integrase Inhibitor Resistance Mutations Among Therapy-Naïve HIV Patients in Southeast China

Lai J, Liu Y, Han X, Huang A, Lin J, Ao W, Ye H, Chen Y

Drug Design, Development and Therapy 2021, 15:889-894

Published Date: 26 February 2021

Effects of Sugammadex versus Neostigmine on Intraoperative Coagulation Profiles in Patients with Thyroidectomy

Zhao D, Fang J, Xiong W, Lin J, Chen W, Wu C

Drug Design, Development and Therapy 2021, 15:829-834

Published Date: 25 February 2021

Efficacy and Safety of Retinol Palmitate Ophthalmic Solution in the Treatment of Dry Eye: A Japanese Phase II Clinical Trial [Corrigendum]

Toshida H, Funaki T, Ono K, Tabuchi N, Watanabe S, Seki T, Otake H, Kato T, Ebihara N, Murakami A

Drug Design, Development and Therapy 2021, 15:813-816

Published Date: 24 February 2021

Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin αvβ5 Signaling Pathway

Zhang Y, Shi X, Han J, Peng W, Fang Z, Zhou Y, Xu X, Lin J, Xiao F, Zhao L, Lin Y

Drug Design, Development and Therapy 2021, 15:803-812

Published Date: 23 February 2021

Mechanism of Action of Xiaoyao San in Treatment of Ischemic Stroke is Related to Anti-Apoptosis and Activation of PI3K/Akt Pathway

Xu Y, Chen W, Chen Z, Huang M, Yang F, Zhang Y

Drug Design, Development and Therapy 2021, 15:753-767

Published Date: 22 February 2021

The Effectiveness of Ruxolitinib for Acute/Chronic Graft-versus-Host Disease in Children: A Retrospective Study

Yang W, Zhu G, Qin M, Li Z, Wang B, Yang J, Wang T

Drug Design, Development and Therapy 2021, 15:743-752

Published Date: 22 February 2021

Addition of Celebrex and Pregabalin to Ropivacaine for Posterior Spinal Surgery: A Randomized, Double-Blinded, Placebo-Controlled Trial

Zhang Y, He B, Zhao J, Zhang M, Ren Q, Zhang W, Xu S, Quan Z, Ou Y

Drug Design, Development and Therapy 2021, 15:735-742

Published Date: 22 February 2021

The Risks of miRNA Therapeutics: In a Drug Target Perspective

Zhang S, Cheng Z, Wang Y, Han T

Drug Design, Development and Therapy 2021, 15:721-733

Published Date: 22 February 2021

Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation

Feng SH, Zhao B, Zhan X, Motanyane R, Wang SM, Li A

Drug Design, Development and Therapy 2021, 15:705-720

Published Date: 24 February 2021

Glucocorticoid-Like Activity of Escin: A New Mechanism for an Old Drug

Gallelli L, Cione E, Wang T, Zhang L

Drug Design, Development and Therapy 2021, 15:699-704

Published Date: 24 February 2021

Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway

Luo X, Zhao B, Chen B, Chen H, Han T, Bsoul NBN, Yan H

Drug Design, Development and Therapy 2021, 15:679-688

Published Date: 18 February 2021

Thiazole-Based Thiosemicarbazones: Synthesis, Cytotoxicity Evaluation and Molecular Docking Study

Gomha SM, Abdelhady HA, Hassain DZH, Abdelmonsef AH, El-Naggar M, Elaasser MM, Mahmoud HK

Drug Design, Development and Therapy 2021, 15:659-677

Published Date: 17 February 2021

Progress in Clinical Research on Gonadotropin-Releasing Hormone Receptor Antagonists for the Treatment of Prostate Cancer

Liu YF, Fu SQ, Yan YC, Gong BB, Xie WJ, Yang XR, Sun T, Ma M

Drug Design, Development and Therapy 2021, 15:639-649

Published Date: 16 February 2021

Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity

Sun W, Hu B, Zhang X, Wang Y, Xiang Z, Lin G

Drug Design, Development and Therapy 2021, 15:611-616

Published Date: 16 February 2021

Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells

Xu W, Xie S, Chen X, Pan S, Qian H, Zhu X

Drug Design, Development and Therapy 2021, 15:577-588

Published Date: 15 February 2021

Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer

Yin HF, Yin CM, Ouyang T, Sun SD, Chen WG, Yang XL, He X, Zhang CF

Drug Design, Development and Therapy 2021, 15:557-576

Published Date: 12 February 2021

Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway

Zheng B, Yang Y, Li J, Li J, Zuo S, Chu X, Xu S, Ma D, Chu L

Drug Design, Development and Therapy 2021, 15:543-556

Published Date: 12 February 2021

Synergistic Anticancer Strategy of Sonodynamic Therapy Combined with PI-103 Against Hepatocellular Carcinoma

Yang H, Jing H, Han X, Tan H, Cheng W

Drug Design, Development and Therapy 2021, 15:531-542

Published Date: 11 February 2021

L-Cysteine Provides Neuroprotection of Hypoxia-Ischemia Injury in Neonatal Mice via a PI3K/Akt-Dependent Mechanism

Li T, Li J, Li T, Zhao Y, Ke H, Wang S, Liu D, Wang Z

Drug Design, Development and Therapy 2021, 15:517-529

Published Date: 11 February 2021

Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways

Zhang J, Wang C, Kang K, Liu H, Liu X, Jia X, Yu K

Drug Design, Development and Therapy 2021, 15:501-513

Published Date: 11 February 2021

EGCG Regulates Cell Apoptosis of Human Umbilical Vein Endothelial Cells Grown on 316L Stainless Steel for Stent Implantation

Wang J, Wang Y, Zhao Y, Zhao J, Zhang B, Xu K

Drug Design, Development and Therapy 2021, 15:493-499

Published Date: 11 February 2021

Profile of Enfortumab Vedotin in the Treatment of Urothelial Carcinoma: The Evidence to Date

Moussa M, Papatsoris A, Abou Chakra M, Dellis A

Drug Design, Development and Therapy 2021, 15:453-462

Published Date: 11 February 2021

Effect of Evodiamine on Rat Colonic Hypermotility Induced by Water Avoidance Stress and the Underlying Mechanism

Ren H, Yuan F, Tan W, Ding Y, An P, Luo H

Drug Design, Development and Therapy 2021, 15:441-452

Published Date: 10 February 2021

Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents

Hassan Mir R, Godavari G, Siddiqui NA, Ahmad B, Mothana RA, Ullah R, Almarfadi OM, Jachak SM, Masoodi MH

Drug Design, Development and Therapy 2021, 15:385-397

Published Date: 4 February 2021

Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice

Malik Z, Abbas M, Al Kury LT, Shah FA, Alam M, Khan AU, Nadeem H, Alghamdi S, Sahibzada MUK, Li S

Drug Design, Development and Therapy 2021, 15:369-384

Published Date: 4 February 2021

Irisin Protects Against Hind Limb Ischemia Reperfusion Injury

Küçük A, Polat Y, Kılıçarslan A, Süngü N, Kartal H, Dursun AD, Arslan M

Drug Design, Development and Therapy 2021, 15:361-368

Published Date: 4 February 2021

New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations

Bíró T, Bocsik A, Jurišić Dukovski B, Gróf I, Lovrić J, Csóka I, Deli MA, Aigner Z

Drug Design, Development and Therapy 2021, 15:351-360

Published Date: 3 February 2021

CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma

Lin J, Qin H, Han Y, Li X, Zhao Y, Zhai G

Drug Design, Development and Therapy 2021, 15:323-330

Published Date: 27 January 2021

Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients

Fityatal Hasanah YI, Harahap Y, Purwanto DJ

Drug Design, Development and Therapy 2021, 15:305-313

Published Date: 26 January 2021

Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway

Dong X, Wang L, Song G, Cai X, Wang W, Chen J, Wang G

Drug Design, Development and Therapy 2021, 15:277-287

Published Date: 25 January 2021

Effects of Caffeic Acid and Its Derivatives on Bone: A Systematic Review

Ekeuku SO, Pang KL, Chin KY

Drug Design, Development and Therapy 2021, 15:259-275

Published Date: 22 January 2021

Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis

Wang Y, Wang Q, Li X, Luo G, Shen M, Shi J, Wang X, Tang L

Drug Design, Development and Therapy 2021, 15:245-257

Published Date: 22 January 2021

Gracillin Isolated from Reineckia carnea Induces Apoptosis of A549 Cells via the Mitochondrial Pathway

Yang J, Cao L, Li Y, Liu H, Zhang M, Ma H, Wang B, Yuan X, Liu Q

Drug Design, Development and Therapy 2021, 15:233-243

Published Date: 20 January 2021

Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy [Corrigendum]

Zhang X, Deng Y, Xiang J, Liu H, Zhang J, Liao J, Chen K, Liu B, Liu J, Pu Y

Drug Design, Development and Therapy 2021, 15:231-232

Published Date: 20 January 2021

Clinical Significance of Continuable Treatment with Nintedanib Over 12 Months for Idiopathic Pulmonary Fibrosis in a Real-World Setting

Kato M, Sasaki S, Tateyama M, Arai Y, Motomura H, Sumiyoshi I, Ochi Y, Watanabe J, Ihara H, Togo S, Takahashi K

Drug Design, Development and Therapy 2021, 15:223-230

Published Date: 18 January 2021

H2O2-Inactivated Salmonella typhimurium RE88 Strain as a New Cancer Vaccine Carrier: Evaluation in a Mouse Model of Cancer

Fan Y, Bai T, Tian Y, Zhou B, Wang Y, Yang L

Drug Design, Development and Therapy 2021, 15:209-222

Published Date: 15 January 2021

Quaternary Lidocaine Derivatives: Past, Present, and Future

Wang Q, Zhang Y, Liu J, Zhang W

Drug Design, Development and Therapy 2021, 15:195-207

Published Date: 14 January 2021

Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions

Wang MN, Yu HT, Li YQ, Zeng Y, Yang S, Yang GP, Pei Q, Huang J

Drug Design, Development and Therapy 2021, 15:185-193

Published Date: 14 January 2021

Combination of Sodium Cantharidinate with Cisplatin Synergistically Hampers Growth of Cervical Cancer

Chen X, Zhou M, Fan W, Yang M, Yang L

Drug Design, Development and Therapy 2021, 15:171-183

Published Date: 13 January 2021

Subcutaneous Delivery of High-Dose/Volume Biologics: Current Status and Prospect for Future Advancements

Badkar AV, Gandhi RB, Davis SP, LaBarre MJ

Drug Design, Development and Therapy 2021, 15:159-170

Published Date: 13 January 2021

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

Chen M, Xiao C, Jiang W, Yang W, Qin Q, Tan Q, Lian B, Liang Z, Wei C

Drug Design, Development and Therapy 2021, 15:125-140

Published Date: 12 January 2021

Chronic Obstructive Pulmonary Disease Treatment and Pharmacist-Led Medication Management

Li LC, Han YY, Zhang ZH, Zhou WC, Fang HM, Qu J, Kan LD

Drug Design, Development and Therapy 2021, 15:111-124

Published Date: 12 January 2021

Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity

Xu J, Guan Z, Wang X, Sun D, Li Y, Pei B, Lu Y, Yuan L, Zhang X

Drug Design, Development and Therapy 2021, 15:99-110

Published Date: 12 January 2021

A Review of Drug Therapy in Vestibular Schwannoma

Long J, Zhang Y, Huang X, Ren J, Zhong P, Wang B

Drug Design, Development and Therapy 2021, 15:75-85

Published Date: 8 January 2021

Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass

Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, Yu W, Dong X

Drug Design, Development and Therapy 2021, 15:51-60

Published Date: 7 January 2021

RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway

Wang J, Zhang X, Yang F, Yang Y, Wang T, Liu W, Zhou H, Zhao W

Drug Design, Development and Therapy 2021, 15:21-35

Published Date: 6 January 2021

Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy

Rudzińska M, Daglioglu C, Savvateeva LV, Kaci FN, Antoine R, Zamyatnin Jr AA

Drug Design, Development and Therapy 2021, 15:9-20

Published Date: 6 January 2021