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Drug Design, Development and Therapy
ISSN: 1177-8881
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Archive: Volume 13, 2019
Progestin-Primed Ovarian Stimulation with Dydrogesterone versus Medroxyprogesterone Acetate in Women with Polycystic Ovarian Syndrome for in vitro Fertilization: A Retrospective Cohort Study
Huang J, Xie Q, Lin J, Lu X, Zhu J, Gao H, Cai R, Kuang Y
Drug Design, Development and Therapy 2019, 13:4461-4470
Published Date: 3 January 2020
Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling Pathway
Kang K, Wang Y
Drug Design, Development and Therapy 2019, 13:4451-4460
Published Date: 31 December 2019
Dexmedetomidine Promotes Hippocampal Neurogenesis and Improves Spatial Learning and Memory in Neonatal Rats
Zhang Y, Gao Q, Wu Z, Xue H, Liu B, Zhao P
Drug Design, Development and Therapy 2019, 13:4439-4449
Published Date: 3 January 2020
Generic Tacrolimus (Tacrobell®) Shows Comparable Outcomes to Brand-Name Tacrolimus in the Long-Term Period After Adult Deceased Donor Liver Transplantation
Kim JM, Joh JW, Choi GS, Lee SK
Drug Design, Development and Therapy 2019, 13:4431-4438
Published Date: 31 December 2019
Development and Evaluation of in-situ Nasal Gel Formulations of Nanosized Transferosomal Sumatriptan: Design, Optimization, in vitro and in vivo Evaluation
Omar MM, Eleraky NE, El Sisi AM, Ali Hasan O
Drug Design, Development and Therapy 2019, 13:4413-4430
Published Date: 27 December 2019
Developmental Pharmacogenetics of SLCO2B1 on Montelukast Pharmacokinetics in Chinese Children
Li Q, Wang K, Shi HY, Wu YE, Zhou Y, Kan M, Zheng Y, Hao GX, Yang XM, Yang YL, Su LQ, Wang XL, Jacqz-Aigrain E, Zhou J, Zhao W
Drug Design, Development and Therapy 2019, 13:4405-4411
Published Date: 27 December 2019
An Efficient, Lung-Targeted, Drug-Delivery System To Treat Asthma Via Microparticles
SreeHarsha N, Venugopala KN, Nair AB, Roopashree TS, Attimarad M, Hiremath JG, Al-Dhubiab BE, Ramnarayanan C, Shinu P, Handral M, Haroun M, Tratrat C
Drug Design, Development and Therapy 2019, 13:4389-4403
Published Date: 27 December 2019
Inhibition of Disruptor of Telomeric Silencing 1-Like Alleviated Renal Ischemia and Reperfusion Injury-Induced Fibrosis by Blocking PI3K/AKT-Mediated Oxidative Stress
Yang C, Chen Z, Yu H, Liu X
Drug Design, Development and Therapy 2019, 13:4375-4387
Published Date: 27 December 2019
Cytokine and Chemokine Profile Changes in Patients After Intravitreal Conbercept Injection for Diabetic Macular Edema
Wei Q, Wan Z, Hu Y, Peng Q
Drug Design, Development and Therapy 2019, 13:4367-4374
Published Date: 24 December 2019
Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence
Bhagwat SS, Nandanwar M, Kansagara A, Patel A, Takalkar S, Chavan R, Periasamy H, Yeole R, Deshpande PK, Bhavsar S, Bhatia A, Ahdal J, Jain R, Patel M
Drug Design, Development and Therapy 2019, 13:4351-4365
Published Date: 24 December 2019
Memory Impairment Induced by Chronic Psychosocial Stress Is Prevented by L-Carnitine
Rababa'h SY, Alzoubi KH, Hammad HM, Alquraan L, El-Salem K
Drug Design, Development and Therapy 2019, 13:4341-4350
Published Date: 19 December 2019
Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cell Therapy for Rheumatoid Arthritis Patients: A Prospective Phase I/II Study
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y
Drug Design, Development and Therapy 2019, 13:4331-4340
Published Date: 19 December 2019
AR-42: A Pan-HDAC Inhibitor with Antitumor and Antiangiogenic Activities in Esophageal Squamous Cell Carcinoma
Zhu Y, Yuan T, Zhang Y, Shi J, Bai L, Duan X, Tong R, Zhong L
Drug Design, Development and Therapy 2019, 13:4321-4330
Published Date: 19 December 2019
A Novel Nanomicellar Combination of Fenretinide and Lenalidomide Shows Marked Antitumor Activity in a Neuroblastoma Xenograft Model
Orienti I, Nguyen F, Guan P, Kolla V, Calonghi N, Farruggia G, Chorny M, Brodeur GM
Drug Design, Development and Therapy 2019, 13:4305-4319
Published Date: 19 December 2019
The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss
Nan B, Gu X, Huang X
Drug Design, Development and Therapy 2019, 13:4291-4303
Published Date: 18 December 2019
The Protective Role of Tanshinone IIA in Silicosis Rat Model via TGF-β1/Smad Signaling Suppression, NOX4 Inhibition and Nrf2/ARE Signaling Activation
Feng F, Cheng P, Zhang H, Li N, Qi Y, Wang H, Wang Y, Wang W
Drug Design, Development and Therapy 2019, 13:4275-4290
Published Date: 18 December 2019
Valproic Acid Addresses Neuroendocrine Differentiation of LNCaP Cells and Maintains Cell Survival
Giordano F, Naimo GD, Nigro A, Romeo F, Paolì A, De Amicis F, Vivacqua A, Morelli C, Mauro L, Panno ML
Drug Design, Development and Therapy 2019, 13:4265-4274
Published Date: 18 December 2019
Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds
Ibrahim TM, Ernst C, Lange A, Hennig S, Boeckler FM
Drug Design, Development and Therapy 2019, 13:4247-4263
Published Date: 18 December 2019
Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells
Wu J, Dai J, Zhang Y, Wang J, Huang L, Ding H, Li T, Zhang Y, Mao J, Yu S
Drug Design, Development and Therapy 2019, 13:4239-4246
Published Date: 13 December 2019
Molecular Requirements for the Expression of Antiplatelet Effects by Synthetic Structural Optimized Analogues of the Anticancer Drugs Imatinib and Nilotinib
Pantazi D, Ntemou N, Brentas A, Alivertis D, Skobridis K, Tselepis AD
Drug Design, Development and Therapy 2019, 13:4225-4238
Published Date: 12 December 2019
The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise
Nemati A, Alipanah-Moghadam R, Molazadeh L, Naghizadeh Baghi A
Drug Design, Development and Therapy 2019, 13:4215-4223
Published Date: 11 December 2019
Drug–Drug Interactions Of Amiodarone And Quinidine On The Pharmacokinetics Of Eliglustat In Rats
Wang Q, Wang H, Zhong Y, Zhang Q
Drug Design, Development and Therapy 2019, 13:4207-4213
Published Date: 12 December 2019
In Silico, Cytotoxic and Antioxidant Potential of Novel Ester, 3-hydroxyoctyl -5- trans-docosenoate Isolated from Anchusa arvensis (L.) M.Bieb. Against HepG-2 Cancer Cells
Hussain S, Ullah F, Ayaz M, Ali Shah SA, Ali Shah AH, Shah SM, Wadood A, Aman W, Ullah R, Shahat AA, Nasr FA
Drug Design, Development and Therapy 2019, 13:4195-4205
Published Date: 10 December 2019
Pharmacological Evaluation of Aldehydic-Pyrrolidinedione Against HCT-116, MDA-MB231, NIH/3T3, MCF-7 Cancer Cell Lines, Antioxidant and Enzyme Inhibition Studies
Ahmad A, Ullah F, Sadiq A, Ayaz M, Rahim H, Rashid U, Ahmad S, Jan MS, Ullah R, Shahat AA, Mahmood HM
Drug Design, Development and Therapy 2019, 13:4185-4194
Published Date: 10 December 2019
Preparation of a Novel One-Armed Anti-c-Met Antibody with Antitumor Activity Against Hepatocellular Carcinoma
Yin Y, Guo J, Teng F, Yu L, Jiang Y, Xie K, Jiang M, Fang J
Drug Design, Development and Therapy 2019, 13:4173-4184
Published Date: 10 December 2019
Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury
Xiao Z, Xu F, Zhu X, Bai B, Guo L, Liang G, Shan X, Zhang Y, Zhao Y, Zhang B
Drug Design, Development and Therapy 2019, 13:4161-4171
Published Date: 10 December 2019
A Novel Hybrid Compound LLP2A-Alendronate Accelerates Open Fracture Healing in a Rabbit Model [Corrigendum]
Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A
Drug Design, Development and Therapy 2019, 13:4159-4160
Published Date: 9 December 2019
Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway
Zhu HF, Shao Y, Qin L, Wang JH, Feng S, Jiang YB, Wan D
Drug Design, Development and Therapy 2019, 13:4145-4157
Published Date: 10 December 2019
Pharmacokinetics and Safety of Esketamine in Chinese Patients Undergoing Painless Gastroscopy in Comparison with Ketamine: A Randomized, Open-Label Clinical Study
Wang J, Huang J, Yang S, Cui C, Ye L, Wang S, Yang G, Pei Q
Drug Design, Development and Therapy 2019, 13:4135-4144
Published Date: 6 December 2019
Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation
Torabizadeh SA, Rezaeifar M, Jomehzadeh A, Nabizadeh Haghighi F, Ansari M
Drug Design, Development and Therapy 2019, 13:4127-4134
Published Date: 6 December 2019
Hongjingtian Injection Inhibits Proliferation and Migration and Promotes Apoptosis in High Glucose-Induced Vascular Smooth Muscle Cells
Fan Z, Guo C, Zhang Y, Yao J, Liao L, Dong J
Drug Design, Development and Therapy 2019, 13:4115-4126
Published Date: 5 December 2019
Efficacy and Safety of Combined Vitrectomy with Intravitreal Dexamethasone Implant for Advanced Stage Epiretinal Membrane
Iovino C, Giannaccare G, Pellegrini M, Bernabei F, Braghiroli M, Caporossi T, Peiretti E
Drug Design, Development and Therapy 2019, 13:4107-4114
Published Date: 3 December 2019
Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data
Varyani F, Argyriou K, Phillips F, Tsakiridou E, Moran GW
Drug Design, Development and Therapy 2019, 13:4091-4105
Published Date: 2 December 2019
Cinobufagin Suppresses The Characteristics Of Osteosarcoma Cancer Cells By Inhibiting The IL-6-OPN-STAT3 Pathway
Zhang C, Ma K, Li WY
Drug Design, Development and Therapy 2019, 13:4075-4090
Published Date: 4 December 2019
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways
Luo Y, Yang P, Li Z, Luo Y, Shen J, Li R, Zheng H, Liang Y, Xia N
Drug Design, Development and Therapy 2019, 13:4065-4074
Published Date: 2 December 2019
Neuroprotective Effect of S-trans, Trans-farnesylthiosalicylic Acid via Inhibition of RAS/ERK Pathway for the Treatment of Alzheimer’s Disease
Wang X, Wang Y, Zhu Y, Yan L, Zhao L
Drug Design, Development and Therapy 2019, 13:4053-4063
Published Date: 29 November 2019
An Optimized Surfactant-Based PEG-PLCL In Situ Gel Formulation For Enhanced Activity Of Rosuvastatin In Poloxamer-Induced Hyperlipidemic Rats
Ahmed TA, Mussari MA, Abdel-Hady SES, El-Say KM
Drug Design, Development and Therapy 2019, 13:4035-4051
Published Date: 3 December 2019
Delivery Of Curcumin Nanoliposomes Using Surface Modified With CD133 Aptamers For Prostate Cancer
Ma Q, Qian W, Tao W, Zhou Y, Xue B
Drug Design, Development and Therapy 2019, 13:4021-4033
Published Date: 28 November 2019
Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia
Bartos C, Ambrus R, Katona G, Sovány T, Gáspár R, Márki Á, Ducza E, Ivanov A, Tömösi F, Janáky T, Szabó-Révész P
Drug Design, Development and Therapy 2019, 13:4007-4020
Published Date: 28 November 2019
A Network Pharmacology-Based Strategy For Predicting Active Ingredients And Potential Targets Of LiuWei DiHuang Pill In Treating Type 2 Diabetes Mellitus
He D, Huang JH, Zhang ZY, Du Q, Peng WJ, Yu R, Zhang SF, Zhang SH, Qin YH
Drug Design, Development and Therapy 2019, 13:3989-4005
Published Date: 28 November 2019
Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride
Ren JY, Lin DM, Wang CB, Yang YL, Wang ZQ, Cui BQ, Ma J
Drug Design, Development and Therapy 2019, 13:3977-3988
Published Date: 26 November 2019
Effects Of Triptolide On Tooth Movement And Root Resorption In Rats
Yang F, Wang XX, Ma D, Cui Q, Zheng DH, Liu XC, Zhang J
Drug Design, Development and Therapy 2019, 13:3963-3975
Published Date: 25 November 2019
Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes
Zuo S, Zou W, Wu RM, Yang J, Fan JN, Zhao XK, Li HY
Drug Design, Development and Therapy 2019, 13:3949-3961
Published Date: 21 November 2019
Alteration of Amino Acid Profiling Influenced by the Active Ingredients of DanHong Injection After Prescription Optimization
Guo Z, Zhu Y, Xu W, Luo K, Xiao H, Wang Z
Drug Design, Development and Therapy 2019, 13:3939-3947
Published Date: 21 November 2019
Assessment Of Spanlastic Vesicles Of Zolmitriptan For Treating Migraine In Rats
El-Nabarawy NA, Teaima MH, Helal DA
Drug Design, Development and Therapy 2019, 13:3929-3937
Published Date: 21 November 2019
The Effects Of Sevoflurane On The Progression And Cisplatinum Sensitivity Of Cervical Cancer Cells
Xue F, Xu Y, Song Y, Zhang W, Li R, Zhu X
Drug Design, Development and Therapy 2019, 13:3919-3928
Published Date: 18 November 2019
Efficacy And Safety Of Apatinib Treatment In Platinum-Resistant Recurrent Epithelial Ovarian Cancer: A Real World Study
Zhang J, Li A, Jiang Q, Zheng F, Zhu H
Drug Design, Development and Therapy 2019, 13:3913-3918
Published Date: 15 November 2019
Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response
Ding X, Zheng L, Yang B, Wang X, Ying Y
Drug Design, Development and Therapy 2019, 13:3899-3911
Published Date: 18 November 2019
The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity
Chou AH, Liao CC, Lee HC, Liou JT, Liu FC
Drug Design, Development and Therapy 2019, 13:3887-3898
Published Date: 14 November 2019
A Fixed-Dose Combination Of Gemigliptin And Rosuvastatin Exhibits Similar Pharmacokinetics, Pharmacodynamics, And Safety Compared To That Of A Loose Combination In Healthy Subjects
Kim E, Park KR, Jang IJ, Yu KS, Lee S
Drug Design, Development and Therapy 2019, 13:3879-3885
Published Date: 13 November 2019
Pregnancy And Neonatal Outcomes Of hMG Stimulation With Or Without Letrozole In Endometrial Preparation For Frozen–Thawed Embryo Transfer In Ovulatory Women: A Large Retrospective Cohort Study
Lin J, Wang N, Huang J, Cai R, Fan Y, Kuang Y, Wang Y
Drug Design, Development and Therapy 2019, 13:3867-3877
Published Date: 14 November 2019
Hesperidin: A Therapeutic Agent For Obesity
Xiong H, Wang J, Ran Q, Lou G, Peng C, Gan Q, Hu J, Sun J, Yao R, Huang Q
Drug Design, Development and Therapy 2019, 13:3855-3866
Published Date: 12 November 2019
Safety, pharmacokinetics and pharmacodynamics of the selective glucocorticoid receptor modulator AZD7594, following inhalation in healthy Japanese volunteers
Prothon S, Wählby Hamrén U, Tehler U, Yoon E, Forsman H, Arfvidsson C, Aggarwal A, Chen Y
Drug Design, Development and Therapy 2019, 13:3845-3853
Published Date: 12 November 2019
Adenosine Inhibits Ovarian Cancer Growth Through Regulating RhoGDI2 Protein Expression
Xia B, Wang J
Drug Design, Development and Therapy 2019, 13:3837-3844
Published Date: 8 November 2019
The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers [Erratum]
Cheng Y, Lin BJ, Guo JH, Huang BL, Fang LP, Que WC, Liu MB, Chen XF, Qiu HQ
Drug Design, Development and Therapy 2019, 13:3835-3836
Published Date: 7 November 2019
Identification Of Natural Compound Derivative For Inhibition Of XLF And Overcoming Chemoresistance In Colorectal Cancer Cells
Liu Z, Yu M, Fei B, Sun J, Wang D
Drug Design, Development and Therapy 2019, 13:3823-3834
Published Date: 6 November 2019
Comparing The Efficacy Of An Anti-Human VEGF-A Neutralizing Antibody Versus Bevacizumab On A Laser-Induced Choroidal Neovascularization (CNV) Rhesus Monkey Model
Olvera-Montaño O, Baiza-Duran L, Quintana-Hau JD, Quiñonez-Alvarado MG, Zeng W, Gong L, Muñoz-Villegas P
Drug Design, Development and Therapy 2019, 13:3813-3821
Published Date: 4 November 2019
Id-1 Promotes Reendothelialization In The Early Phase After Vascular Injury Through Activation Of NFkB/survivin Signaling Pathway
Li W, Du D, Li Y
Drug Design, Development and Therapy 2019, 13:3799-3811
Published Date: 31 October 2019
Subarachnoid and epidural dexmedetomidine for the prevention of post-anesthetic shivering: a meta-analysis and systematic review
Li YZ, Jiang Y, Lin H, Yang XP
Drug Design, Development and Therapy 2019, 13:3785-3798
Published Date: 1 November 2019
Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway
Jiang T, Zhang L, Ding M, Li M
Drug Design, Development and Therapy 2019, 13:3773-3784
Published Date: 31 October 2019
Smart Targeting To Improve Cancer Therapeutics
Morales-Cruz M, Delgado Y, Castillo B, Figueroa CM, Molina AM, Torres A, Milián M, Griebenow K
Drug Design, Development and Therapy 2019, 13:3753-3772
Published Date: 30 October 2019
Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties
Liu Y, Xu X, Xu R, Zhang S
Drug Design, Development and Therapy 2019, 13:3735-3751
Published Date: 30 October 2019
Baseline Lymphopenia: A Predictor Of Poor Outcomes In HER2 positive Metastatic Breast Cancer Treated With Trastuzumab
Che YQ, Zhang Y, Wang D, Liu HY, Shen D, Luo Y
Drug Design, Development and Therapy 2019, 13:3727-3734
Published Date: 29 October 2019
miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways
Yu Y, Xiang N, Lin M, Huang JW, Zhang J, Cheng B, Ji C
Drug Design, Development and Therapy 2019, 13:3717-3726
Published Date: 29 October 2019
Cardio- Renal Outcomes With Long- Term Agalsidase Alfa Enzyme Replacement Therapy: A 10- Year Fabry Outcome Survey (FOS) Analysis
Ramaswami U, Beck M, Hughes D, Kampmann C, Botha J, Pintos-Morell G, West ML, Niu DM, Nicholls K, Giugliani R
Drug Design, Development and Therapy 2019, 13:3705-3715
Published Date: 25 October 2019
Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury
Zhao C, Zhou X, Qiu J, Xin D, Li T, Chu X, Yuan H, Wang H, Wang Z, Wang D
Drug Design, Development and Therapy 2019, 13:3693-3704
Published Date: 24 October 2019
Glucoside Derivatives Of Podophyllotoxin: Synthesis, Physicochemical Properties, And Cytotoxicity
Zi CT, Yang L, Kong QH, Li HM, Yang XZ, Ding ZT, Jiang ZH, Hu JM, Zhou J
Drug Design, Development and Therapy 2019, 13:3683-3692
Published Date: 23 October 2019
A Novel Octapeptide Derived From G Protein-Coupled Receptor 124 Improves Cognitive Function Via Pro-Angiogenesis In A Rat Model Of Chronic Cerebral Hypoperfusion-Induced Vascular Dementia
Xiao Y, Shen H, Li R, Zhou X, Xiao H, Yan J
Drug Design, Development and Therapy 2019, 13:3669-3682
Published Date: 23 October 2019
Olmesartan Medoxomil, An Angiotensin II-Receptor Blocker, Ameliorates Renal Injury In db/db Mice
Zhu Y, Li ZL, Ding A, Yang H, Zhu WP, Cui TX, Zhang HT, Zhang H
Drug Design, Development and Therapy 2019, 13:3657-3667
Published Date: 22 October 2019
Coenzyme q10 liquid supplementation in dyslipidemic subjects with statin-related clinical symptoms: a double-blind, randomized, placebo-controlled study
Derosa G, D'Angelo A, Maffioli P
Drug Design, Development and Therapy 2019, 13:3647-3655
Published Date: 21 October 2019
Lanadelumab Injection Treatment For The Prevention Of Hereditary Angioedema (HAE): Design, Development And Place In Therapy
Bova M, Valerieva A, Wu MA, Senter R, Perego F
Drug Design, Development and Therapy 2019, 13:3635-3646
Published Date: 22 October 2019
The Effect Of Food On The Pharmacokinetic Properties And Bioequivalence Of Two Formulations Of Levocetirizine Dihydrochloride In Healthy Chinese Volunteers
Cheng Y, Lin BJ, Guo JH, Huang BL, Fang LP, Que WC, Liu MB, Chen XF, Qiu HQ
Drug Design, Development and Therapy 2019, 13:3625-3634
Published Date: 18 October 2019
MicroRNA-384-5p/Beclin-1 As Potential Indicators For Epigallocatechin Gallate Against Cardiomyocytes Ischemia Reperfusion Injury By Inhibiting Autophagy Via PI3K/Akt Pathway
Zhang C, Liang R, Gan X, Yang X, Chen L, Jian J
Drug Design, Development and Therapy 2019, 13:3607-3623
Published Date: 17 October 2019
In-vitro blood-brain barrier models for drug screening and permeation studies: an overview
Bagchi S, Chhibber T, Lahooti B, Verma A, Borse V, Jayant RD
Drug Design, Development and Therapy 2019, 13:3591-3605
Published Date: 18 October 2019
Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs
Gao M, Li X, He L, Yang J, Ye X, Xiao F, Wei H
Drug Design, Development and Therapy 2019, 13:3579-3589
Published Date: 16 October 2019
Formulation, Characterization And Evaluation Of Curcumin- Loaded PLGA- TPGS Nanoparticles For Liver Cancer Treatment
Chen XP, Li Y, Zhang Y, Li GW
Drug Design, Development and Therapy 2019, 13:3569-3578
Published Date: 16 October 2019
Tanshinone I Inhibits IL-1β-Induced Apoptosis, Inflammation And Extracellular Matrix Degradation In Chondrocytes CHON-001 Cells And Attenuates Murine Osteoarthritis
Wang X, Fan J, Ding X, Sun Y, Cui Z, Liu W
Drug Design, Development and Therapy 2019, 13:3559-3568
Published Date: 15 October 2019
Clinical And Bacteriological Impact Of Clarithromycin In Streptococcal Pharyngitis: Findings From A Meta-Analysis Of Clinical Trials
Hoban DJ, Nauta J
Drug Design, Development and Therapy 2019, 13:3551-3558
Published Date: 16 October 2019
Indole-2-Carboxamide Derivative LG25 Inhibits Triple-Negative Breast Cancer Growth By Suppressing Akt/mTOR/NF-κB Signalling Pathway
Xu X, Rajamanickam V, Shu S, Liu Z, Yan T, He J, Liu Z, Guo G, Liang G, Wang Y
Drug Design, Development and Therapy 2019, 13:3539-3550
Published Date: 11 October 2019
Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model
Wang B, Jiang Y, Yao Z, Chen P, Yu B, Wang S
Drug Design, Development and Therapy 2019, 13:3529-3538
Published Date: 9 October 2019
20(S)-Ginsenoside Rg3 Promotes Senescence And Apoptosis In Gallbladder Cancer Cells Via The P53 Pathway [Corrigendum]
Zhang F, Li M, Wu X, Hu Y, Cao Y, Wang X, Xiang S, Li H, Jiang L, Tan Z, Lu W, Weng H, Shu Y, Gong W, Wang X, Zhang Y, Shi W, Dong P, Gu J, Liu Y
Drug Design, Development and Therapy 2019, 13:3527-3528
Published Date: 8 October 2019
Thrombospondin-1 Serum Levels In Hypertensive Patients With Endothelial Dysfunction After One Year Of Treatment With Perindopril
Buda V, Andor M, Cristescu C, Tomescu MC, Muntean DM, Bâibâță DE, Bordejevic DA, Danciu C, Dalleur O, Coricovac D, Crainiceanu Z, Tudor A, Ledeti I, Petrescu L
Drug Design, Development and Therapy 2019, 13:3515-3526
Published Date: 8 October 2019
The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies
Wong SK, Chin KY, Ima-Nirwana S
Drug Design, Development and Therapy 2019, 13:3497-3514
Published Date: 7 October 2019
Enzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas
Naz S, Zahoor M, Umar MN, Ali B, Ullah R, Shahat AA, Mahmood HM, Sahibzada MUK
Drug Design, Development and Therapy 2019, 13:3485-3495
Published Date: 7 October 2019
Evaluation of the effect of long-term use of antidepressants in the SSRI group on bone density with dental volumetric tomography
Agacayak KS, Guler R, Ilyasov B
Drug Design, Development and Therapy 2019, 13:3477-3484
Published Date: 3 October 2019
Dexmedetomidine Attenuates Neuroinflammation In LPS-Stimulated BV2 Microglia Cells Through Upregulation Of miR-340
Bao Y, Zhu Y, He G, Ni H, Liu C, Ma L, Zhang L, Shi D
Drug Design, Development and Therapy 2019, 13:3465-3475
Published Date: 3 October 2019
Efficacy And Safety Of Travoprost Versus Timolol To Treat Early-Onset Ocular Hypertension Secondary To Vitrectomy: A Randomized Trial
Fang Y, Ku H, Gan D, Jiang R, Sun X
Drug Design, Development and Therapy 2019, 13:3453-3463
Published Date: 30 September 2019
Efficacy, Safety And Feasibility Of Antiemetic Prophylaxis With Fosaprepitant, Granisetron And Dexamethasone In Pediatric Patients With Hemato-Oncological Malignancies
Cabanillas Stanchi KM, Ebinger M, Hartmann U, Queudeville M, Feucht J, Ost M, Koch MS, Malaval C, Mezger M, Schober S, Weber S, Michaelis S, Lange V, Lang P, Handgretinger R, Döring M
Drug Design, Development and Therapy 2019, 13:3439-3451
Published Date: 30 September 2019
Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties
Gallelli L
Drug Design, Development and Therapy 2019, 13:3425-3437
Published Date: 27 September 2019
The Efficacy And Safety Of Apatinib Treatment For Patients With Metastatic Or Recurrent Cervical Cancer: A Retrospective Study
Yu J, Xu Z, Li A, Zhang J, Wang Y, Zhao H, Zhu H
Drug Design, Development and Therapy 2019, 13:3419-3424
Published Date: 26 September 2019
Hydrogels For Peptide Hormones Delivery: Therapeutic And Tissue Engineering Applications
Doostmohammadi M, Ameri A, Mohammadinejad R, Dehghannoudeh N, Banat IM, Ohadi M, Dehghannoudeh G
Drug Design, Development and Therapy 2019, 13:3405-3418
Published Date: 26 September 2019
Paclitaxel alleviated sepsis-induced acute lung injury by activating MUC1 and suppressing TLR-4/NF-κB pathway
Wang YM, Ji R, Chen WW, Huang SW, Zheng YJ, Yang ZT, Qu HP, Chen H, Mao EQ, Chen Y, Chen EZ
Drug Design, Development and Therapy 2019, 13:3391-3404
Published Date: 24 September 2019
Effect Of Bevacizumab On Growth Of Human Nasal Polyposis In Vitro; An Off-Label Use Of Anti-Angiogenic Agent For Nasal Polyposis Treatment
Nemati S, Keihanian F, Saeidinia A, Bakhshaei M
Drug Design, Development and Therapy 2019, 13:3383-3389
Published Date: 24 September 2019
Design, Synthesis, And Evaluation Of Cyanopyridines As Anti-Colorectal Cancer Agents Via Inhibiting STAT3 Pathway
Xu L, Shi L, Qiu S, Chen S, Lin M, Xiang Y, Zhao C, Zhu J, Shen L, Zuo Z
Drug Design, Development and Therapy 2019, 13:3369-3381
Published Date: 24 September 2019
Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats
Folwarczna J, Konarek N, Freier K, Karbowniczek D, Londzin P, Janas A
Drug Design, Development and Therapy 2019, 13:3357-3367
Published Date: 23 September 2019
Effect Of Chinese Herb Danzhi Xiaoyao Pills On Pharmacokinetics Of Venlafaxine In Beagles
Zhu Y, Li S, Chen K, Ma K, Wu D, Qiu X
Drug Design, Development and Therapy 2019, 13:3343-3355
Published Date: 20 September 2019
Bioequivalence Study Of A Fixed-Dose Combination Tablet Containing Melitracen 10 mg And Flupentixol 0.5 mg In Healthy Chinese Volunteers Under Fasted And Fed Conditions
Wu L, Xu C, Wu G, Zhou H, Lv D, Zhai Y, Huang Y, Tang W, Li F, Shentu J
Drug Design, Development and Therapy 2019, 13:3331-3342
Published Date: 19 September 2019
Effects of quercetin, sitagliptin alone or in combination in testicular toxicity induced by doxorubicin in rats
Ahmed ZA, Abtar AN, Othman HH, Aziz TA
Drug Design, Development and Therapy 2019, 13:3321-3329
Published Date: 20 September 2019
Topical anesthetic analgesic therapy using the combination of ropivacaine and dexmedetomidine: hyaluronic acid modified long-acting nanostructured lipid carriers containing a skin penetration enhancer
Yang Y, Qiu D, Liu Y, Chao L
Drug Design, Development and Therapy 2019, 13:3307-3319
Published Date: 18 September 2019
Muscone Promotes The Adipogenic Differentiation Of Human Gingival Mesenchymal Stem Cells By Inhibiting The Wnt/β-Catenin Signaling Pathway
Yuan WX, Wang XX, Zheng DH, Ma D, Cui Q, Yang F, Zhang J
Drug Design, Development and Therapy 2019, 13:3291-3306
Published Date: 18 September 2019
Gemcitabine-loaded RGD modified liposome for ovarian cancer: preparation, characterization and pharmacodynamic studies
Tang Z, Feng W, Yang Y, Wang Q
Drug Design, Development and Therapy 2019, 13:3281-3290
Published Date: 17 September 2019
A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect
Zhao Y, Dai C, Wang Z, Chen W, Liu J, Zhuo R, Yu A, Huang S
Drug Design, Development and Therapy 2019, 13:3269-3280
Published Date: 16 September 2019
Carbocisteine inhibits the expression of Muc5b in COPD mouse model
Song Y, Wang W, Xie Y, Xiang B, Huang X, Guan W, Zheng J
Drug Design, Development and Therapy 2019, 13:3259-3268
Published Date: 16 September 2019
Identification of substandard drug products using electronic tongue: cefdinir suspension as a pilot example
Abu-Khalaf N, Zaid AN, Jaradat N, Alkilany AM, Abulateefeh SR, Al Ramahi R, Ghanem M
Drug Design, Development and Therapy 2019, 13:3249-3258
Published Date: 16 September 2019
Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine
Kiss B, Némethy Z, Fazekas K, Kurkó D, Gyertyán I, Sághy K, Laszlovszky I, Farkas B, Kirschner N, Bolf-Terjéki E, Balázs O, Lendvai B
Drug Design, Development and Therapy 2019, 13:3229-3248
Published Date: 16 September 2019
Ubenimex induces apoptotic and autophagic cell death in rat GH3 and MMQ cells through the ROS/ERK pathway
Wang Y, Pang B, Zhang R, Fu Y, Pang Q
Drug Design, Development and Therapy 2019, 13:3217-3228
Published Date: 12 September 2019
Palliative chemotherapy with or without anti-EGFR therapy for de novo metastatic nasopharyngeal carcinoma: a propensity score-matching study
Sun XS, Liang YJ, Li XY, Liu SL, Chen QY, Tang LQ, Mai HQ
Drug Design, Development and Therapy 2019, 13:3207-3216
Published Date: 10 September 2019
Downregulation of p66Shc can reduce oxidative stress and apoptosis in oxidative stress model of marginal cells of stria vascularis in Sprague Dawley rats
Hao C, Wu X, Zhou R, Zhang H, Zhou Y, Wang X, Feng Y, Mei L, He C, Cai X, Wu L
Drug Design, Development and Therapy 2019, 13:3199-3206
Published Date: 10 September 2019
Clinical evaluation of dacomitinib for the treatment of metastatic non-small cell lung cancer (NSCLC): current perspectives
Lavacchi D, Mazzoni F, Giaccone G
Drug Design, Development and Therapy 2019, 13:3187-3198
Published Date: 6 September 2019
Omalizumab for chronic spontaneous urticaria in “complex” patients: data from real-life clinical practice
Vollono L, Piccolo A, Lanna C, Esposito M, Bavetta M, Campione E, Bianchi L, Diluvio L
Drug Design, Development and Therapy 2019, 13:3181-3186
Published Date: 6 September 2019
Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes
Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S
Drug Design, Development and Therapy 2019, 13:3171-3180
Published Date: 3 September 2019
Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas
Shen Q, Zou S, Sheng B, Zhao M, Sun LZ, Zhu X
Drug Design, Development and Therapy 2019, 13:3161-3170
Published Date: 3 September 2019
The safety, pharmacodynamics, and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male
Kim D, Park MS, Yoo BW, Hong T, Park SJ, Kim CO
Drug Design, Development and Therapy 2019, 13:3151-3159
Published Date: 3 September 2019
Dexmedetomidine protects H9c2 cardiomyocytes against oxygen-glucose deprivation/reoxygenation-induced intracellular calcium overload and apoptosis through regulating FKBP12.6/RyR2 signaling
Yuan M, Meng XW, Ma J, Liu H, Song SY, Chen QC, Liu HY, Zhang J, Song N, Ji FH, Peng K
Drug Design, Development and Therapy 2019, 13:3137-3149
Published Date: 2 September 2019
Pharmacokinetic and bioequivalence study between two formulations of S-1 in Korean gastric cancer patients
Lee HW, Seong SJ, Kang WY, Ohk B, Gwon MR, Kim BK, Cho S, Cho K, Sung YK, Yoon YR, Kim JG
Drug Design, Development and Therapy 2019, 13:3127-3136
Published Date: 3 September 2019
Silibinin attenuates high-fat diet-induced renal fibrosis of diabetic nephropathy
Liu K, Zhou S, Liu J, Wang Y, Zhu F, Liu M
Drug Design, Development and Therapy 2019, 13:3117-3126
Published Date: 29 August 2019
Therapeutic potential of BLT1 antagonist for COPD: involvement of inducing autophagy and ameliorating inflammation
Zhang L, Huang J, Dong R, Feng Y, Zhou M
Drug Design, Development and Therapy 2019, 13:3105-3116
Published Date: 4 September 2019
Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
Yuan YL, Jiang N, Li ZY, Song ZZ, Yang ZH, Xue WH, Zhang XJ, Du Y
Drug Design, Development and Therapy 2019, 13:3091-3103
Published Date: 28 August 2019
Design, synthesis, and biological study of 4-[(2-nitroimidazole-1H-alkyloxyl)aniline]-quinazolines as EGFR inhibitors exerting cytotoxicities both under normoxia and hypoxia
Cheng W, Wang S, Yang Z, Tian X, Hu Y
Drug Design, Development and Therapy 2019, 13:3079-3089
Published Date: 28 August 2019
Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins
Almutairi MS, Hassan ES, Keeton AB, Piazza GA, Abdelhameed AS, Attia MI
Drug Design, Development and Therapy 2019, 13:3069-3078
Published Date: 27 August 2019
Ketamine and depression: a narrative review
Corriger A, Pickering G
Drug Design, Development and Therapy 2019, 13:3051-3067
Published Date: 27 August 2019
Arsenic sulfide induces miR-4665-3p to inhibit gastric cancer cell invasion and migration
Zhang X, Tan Z, Kang T, Zhu C, Chen S
Drug Design, Development and Therapy 2019, 13:3037-3049
Published Date: 26 August 2019
Isolation, pharmacological evaluation and molecular docking studies of bioactive compounds from Grewia optiva
Ul Bari W, Zahoor M, Zeb A, Sahibzada MUK, Ullah R, Shahat AA, Mahmood HM, Khan I
Drug Design, Development and Therapy 2019, 13:3029-3036
Published Date: 26 August 2019
Synthesis and antitumor evaluation of neolaxiflorin B inspired compounds
Liu JP, Xiao YZ, Hu Y, Li XN, Wu MJ, Zhao Y, Zhao Y, Ma ZJ, Shen J
Drug Design, Development and Therapy 2019, 13:3021-3028
Published Date: 23 August 2019
Network pharmacology study on the active components of Pterocypsela elata and the mechanism of their effect against cerebral ischemia
Niu B, Zhang H, Li C, Yan F, Song Y, Hai G, Jiao Y, Feng Y
Drug Design, Development and Therapy 2019, 13:3009-3019
Published Date: 5 September 2019
A network pharmacology approach to explore active compounds and pharmacological mechanisms of epimedium for treatment of premature ovarian insufficiency
Zhao H, Shan Y, Ma Z, Yu M, Gong B
Drug Design, Development and Therapy 2019, 13:2997-3007
Published Date: 22 August 2019
The development of an oral GLP-1 receptor agonist for the management of type 2 diabetes: evidence to date
Antza C, Nirantharakumar K, Doundoulakis I, Tahrani AA, Toulis KA
Drug Design, Development and Therapy 2019, 13:2985-2996
Published Date: 22 August 2019
Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways
Xie W, Huang X, Chen R, Chen R, Li T, Wu W, Huang Z
Drug Design, Development and Therapy 2019, 13:2969-2984
Published Date: 22 August 2019
Attractor – a new turning point in drug discovery
Hou X, Li M, Jia C, Zhang X, Wang Y
Drug Design, Development and Therapy 2019, 13:2957-2968
Published Date: 22 August 2019
Effect of hepatic and renal impairment on the pharmacokinetics of olanzapine and samidorphan given in combination as a bilayer tablet
Sun L, Yagoda S, Du Y, von Moltke L
Drug Design, Development and Therapy 2019, 13:2941-2955
Published Date: 22 August 2019
Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials
Wang YQ, Zhang XJ, Wang Y
Drug Design, Development and Therapy 2019, 13:2933-2939
Published Date: 21 August 2019
Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury
Han M, Hu L, Chen Y
Drug Design, Development and Therapy 2019, 13:2923-2931
Published Date: 20 August 2019
RETRACTED ARTICLE: Impact of postoperative dexmedetomidine infusion on incidence of delirium in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial
Sun Y, Jiang M, Ji Y, Sun Y, Liu Y, Shen W
Drug Design, Development and Therapy 2019, 13:2911-2922
Published Date: 19 August 2019
Clinical application of obinutuzumab for treating chronic lymphocytic leukemia
Luan C, Chen B
Drug Design, Development and Therapy 2019, 13:2899-2909
Published Date: 19 August 2019
Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro
Zhao S, Liu Y, Pu Z
Drug Design, Development and Therapy 2019, 13:2887-2897
Published Date: 19 August 2019
Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro
Qin H, Wen HT, Gu KJ, Hu XD, Yang T, Yan XF, Ye TJ, Huo JL, Hu J
Drug Design, Development and Therapy 2019, 13:2873-2886
Published Date: 19 August 2019
Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study
Mei YB, Luo SB, Ye LY, Zhang Q, Guo J, Qiu XJ, Xie SL
Drug Design, Development and Therapy 2019, 13:2865-2871
Published Date: 15 August 2019
Effects of peri-operative intravenous administration of dexmedetomidine on emergence agitation after general anesthesia in adults: a meta-analysis of randomized controlled trials
Zhang J, Yu Y, Miao S, Liu L, Gan S, Kang X, Zhu S
Drug Design, Development and Therapy 2019, 13:2853-2864
Published Date: 15 August 2019
Denosumab in the treatment of glucocorticoid-induced osteoporosis: a systematic review and meta-analysis
Yanbeiy ZA, Hansen KE
Drug Design, Development and Therapy 2019, 13:2843-2852
Published Date: 14 August 2019
Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo
Ouyang Y, Wang W, Tu B, Zhu Y, Fan C, Li Y
Drug Design, Development and Therapy 2019, 13:2833-2842
Published Date: 13 August 2019
Protective effects of tiopronin against oxidative stress in severely burned patients
Qin FJ, Hu XH, Chen Z, Chen X, Shen YM
Drug Design, Development and Therapy 2019, 13:2827-2832
Published Date: 13 August 2019
Nicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials [Letter]
Li J, Zhang L, Lu A
Drug Design, Development and Therapy 2019, 13:2825-2826
Published Date: 13 August 2019
Piceatannol inhibits oxidative stress through modification of Nrf2-signaling pathway in testes and attenuates spermatogenesis and steroidogenesis in rats exposed to cadmium during adulthood
Shi X, Fu L
Drug Design, Development and Therapy 2019, 13:2811-2824
Published Date: 13 August 2019
eIF2α promotes vascular remodeling via autophagy in monocrotaline-induced pulmonary arterial hypertension rats
Guo L, Li Y, Tian Y, Gong S, Chen X, Peng T, Wang A, Jiang Z
Drug Design, Development and Therapy 2019, 13:2799-2809
Published Date: 13 August 2019
Thapsigargin induces apoptosis in adrenocortical carcinoma by activating endoplasmic reticulum stress and the JNK signaling pathway: an in vitro and in vivo study
Wu L, Huang X, Kuang Y, Xing Z, Deng X, Luo Z
Drug Design, Development and Therapy 2019, 13:2787-2798
Published Date: 12 August 2019
Minoxidil and its use in hair disorders: a review
Suchonwanit P, Thammarucha S, Leerunyakul K
Drug Design, Development and Therapy 2019, 13:2777-2786
Published Date: 9 August 2019
Effects of acarbose and metformin on the inflammatory state in newly diagnosed type 2 diabetes patients: a one-year randomized clinical study
Mo D, Liu S, Ma H, Tian H, Yu H, Zhang X, Tong N, Liao J, Ren Y
Drug Design, Development and Therapy 2019, 13:2769-2776
Published Date: 9 August 2019
Cerebral protection of epigallocatechin gallate (EGCG) via preservation of mitochondrial function and ERK inhibition in a rat resuscitation model
Qin S, Chen MH, Fang W, Tan XF, Xie L, Yang YG, Qin T, Li N
Drug Design, Development and Therapy 2019, 13:2759-2768
Published Date: 7 August 2019
Liraglutide attenuates cardiac remodeling and improves heart function after abdominal aortic constriction through blocking angiotensin II type 1 receptor in rats
Zheng RH, Bai XJ, Zhang WW, Wang J, Bai F, Yan CP, James EA, Bose HS, Wang NP, Zhao Z
Drug Design, Development and Therapy 2019, 13:2745-2757
Published Date: 6 August 2019
Association between the c.415C > T, c.52G > A, and 36_37insGGAGTC polymorphisms of NUDT 15 and thiopurine-induced leukopenia, thiopurine intolerance, and severe hair loss: an updated meta-analysis
Wang R, Liu B, Li J, Xu J, Wang X, Zhao Z, Zhao L
Drug Design, Development and Therapy 2019, 13:2729-2744
Published Date: 5 August 2019
Neuroprotective effects of melatonin and celecoxib against ethanol-induced neurodegeneration: a computational and pharmacological approach
Al Kury LT, Zeb A, Abidin ZU, Irshad N, Malik I, Alvi AM, Khalil AAK, Ahmad S, Faheem M, Khan AU, Shah FA, Li S
Drug Design, Development and Therapy 2019, 13:2715-2727
Published Date: 2 August 2019
RETRACTED ARTICLE: Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway
Zhou X, Liu Z, Huang B, Yan H, Yang C, Li Q, Jin D
Drug Design, Development and Therapy 2019, 13:2703-2713
Published Date: 5 August 2019
Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments
Tao Y, He M, Yang Q, Ma Z, Qu Y, Chen W, Peng G, Teng D
Drug Design, Development and Therapy 2019, 13:2689-2702
Published Date: 7 August 2019
Dextromethorphan and memantine after ketamine analgesia: a randomized control trial
Martin E, Sorel M, Morel V, Marcaillou F, Picard P, Delage N, Tiberghien F, Crosmary MC, Najjar M, Colamarino R, Créach C, Lietar B, Brumauld de Montgazon G, Margot-Duclot A, Loriot MA, Narjoz C, Lambert C, Pereira B, Pickering G
Drug Design, Development and Therapy 2019, 13:2677-2688
Published Date: 2 August 2019
Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice
Wu Y, Li Z, Xiu AY, Meng DX, Wang SN, Zhang CQ
Drug Design, Development and Therapy 2019, 13:2667-2676
Published Date: 1 August 2019
An investigation of the stability of meropenem in elastomeric infusion devices
Foy F, Luna G, Martinez J, Nizich Z, Seet J, Lie K, Sunderland B, Czarniak P
Drug Design, Development and Therapy 2019, 13:2655-2665
Published Date: 1 August 2019
Efficacy of chloral hydrate oral solution for sedation in pediatrics: a systematic review and meta-analysis
Chen Z, Lin M, Huang Z, Zeng L, Huang L, Yu D, Zhang L
Drug Design, Development and Therapy 2019, 13:2643-2653
Published Date: 31 July 2019
Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin
Feng X, Cheng Q, Meng Q, Yang Y, Nie K
Drug Design, Development and Therapy 2019, 13:2633-2641
Published Date: 1 August 2019
Role of heat shock protein 22 in the protective effect of geranylgeranylacetone in response to oxidized-LDL
Gong R, Li XY, Chen HJ, Xu CC, Fang HY, Xiang J, Wu YQ
Drug Design, Development and Therapy 2019, 13:2619-2632
Published Date: 30 July 2019
Effects of losartan and atorvastatin on the development of early posttraumatic joint stiffness in a rat model
Baranowski A, Schlemmer L, Förster K, Slotina E, Mickan T, Truffel S, Klein A, Mattyasovszky SG, Hofmann A, Ritz U, Rommens PM
Drug Design, Development and Therapy 2019, 13:2603-2618
Published Date: 30 July 2019
Nudol, a phenanthrene derivative from Dendrobium nobile, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells
Zhang Y, Zhang Q, Xin W, Liu N, Zhang H
Drug Design, Development and Therapy 2019, 13:2591-2601
Published Date: 29 July 2019
Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway
Qian W, Cai X, Qian Q, Zhuang Q, Yang W, Zhang X, Zhao L
Drug Design, Development and Therapy 2019, 13:2579-2589
Published Date: 29 July 2019
Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C: design, development, and place in therapy
Cotter TG, Jensen DM
Drug Design, Development and Therapy 2019, 13:2565-2577
Published Date: 29 July 2019
Neonatal outcomes and congenital malformations in children born after dydrogesterone application in progestin-primed ovarian stimulation protocol for IVF: a retrospective cohort study
Huang J, Xie Q, Lin J, Lu X, Wang N, Gao H, Cai R, Kuang Y
Drug Design, Development and Therapy 2019, 13:2553-2563
Published Date: 26 July 2019
Erythropoietin enhances osteogenic differentiation of human periodontal ligament stem cells via Wnt/β-catenin signaling pathway
Zheng DH, Wang XX, Ma D, Zhang LN, Qiao QF, Zhang J
Drug Design, Development and Therapy 2019, 13:2543-2552
Published Date: 26 July 2019
Pharmacokinetic interactions between telmisartan/amlodipine and rosuvastatin after multiple oral administrations in healthy Korean male subjects
Moon SJ, Jeon JY, Jang K, Yu KS, Lim Y, Kim MG
Drug Design, Development and Therapy 2019, 13:2533-2542
Published Date: 25 July 2019
Thymol polymeric nanoparticle synthesis and its effects on the toxicity of high glucose on OEC cells: involvement of growth factors and integrin-linked kinase
Karimi E, Abbasi S, Abbasi N
Drug Design, Development and Therapy 2019, 13:2513-2532
Published Date: 25 July 2019
Downregulation of microRNA-23b-3p alleviates IL-1β-induced injury in chondrogenic CHON-001 cells
Yang Q, Zhou Y, Cai P, Fu W, Wang J, Wei Q, Li X
Drug Design, Development and Therapy 2019, 13:2503-2512
Published Date: 23 July 2019
Infliximab and biosimilar infliximab in psoriasis: efficacy, loss of efficacy, and adverse events
Subedi S, Gong Y, Chen Y, Shi Y
Drug Design, Development and Therapy 2019, 13:2491-2502
Published Date: 23 July 2019
Pharmacokinetics and tolerability of IDP-73152 mesylate after a single oral administration under fasted and fed conditions in healthy volunteers
Shin D, Park SI, Lee HS, An KM, Jung J, Lee M, Yu KS
Drug Design, Development and Therapy 2019, 13:2483-2490
Published Date: 24 July 2019
Pharmacokinetics of hard micronized progesterone capsules via vaginal or oral route compared with soft micronized capsules in healthy postmenopausal women: a randomized open-label clinical study
Wang H, Liu M, Fu Q, Deng C
Drug Design, Development and Therapy 2019, 13:2475-2482
Published Date: 23 July 2019
Physicochemical properties and drug-release mechanisms of dual-release bilayer tablet containing mirabegron and fesoterodine fumarate
Lee HG, Park YS, Jeong JH, Kwon YB, Shin DH, Kim JY, Rhee YS, Park ES, Kim DW, Park CW
Drug Design, Development and Therapy 2019, 13:2459-2474
Published Date: 23 July 2019
Novel purine thioglycoside analogs: synthesis, nanoformulation and biological evaluation in in vitro human liver and breast cancer models
Abu-Zaied MA, Loutfy SA, Hassan AE, Elgemeie GH
Drug Design, Development and Therapy 2019, 13:2437-2457
Published Date: 26 July 2019
A randomized controlled trial evaluating the effects of amlodipine on myocardial iron deposition in pediatric patients with thalassemia major
Khaled A, Salem HA, Ezzat DA, Seif HM, Rabee H
Drug Design, Development and Therapy 2019, 13:2427-2436
Published Date: 22 July 2019
Complement system and age-related macular degeneration: drugs and challenges
Wu J, Sun X
Drug Design, Development and Therapy 2019, 13:2413-2425
Published Date: 19 July 2019
Lumacaftor-ivacaftor in the treatment of cystic fibrosis: design, development and place in therapy
Connett GJ
Drug Design, Development and Therapy 2019, 13:2405-2412
Published Date: 19 July 2019
Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane
Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM
Drug Design, Development and Therapy 2019, 13:2393-2404
Published Date: 18 July 2019
A new approach of ocular nebulization with vitamin B12 versus oxytocin for the treatment of dry eye disease: an in vivo confocal microscopy study
Yang J, Liu Y, Xu Y, Li X, Fu J, Jiang X, Chou Y, Ma J, Hao R, Zhang R, Qiu W, Li X
Drug Design, Development and Therapy 2019, 13:2381-2391
Published Date: 18 July 2019
MicroRNA-664 suppresses the growth of cervical cancer cells via targeting c-Kit
Lv M, Ou R, Zhang Q, Lin F, Li X, Wang K, Xu Y
Drug Design, Development and Therapy 2019, 13:2371-2379
Published Date: 17 July 2019
Pharmacokinetics of the Yougui pill in experimental autoimmune encephalomyelitis model rats and its pharmacological activity in vitro
Liu H, Qiu F, Yang X, Zhao H, Bian B, Wang L
Drug Design, Development and Therapy 2019, 13:2357-2370
Published Date: 16 July 2019
Plumbagin promotes human hepatoma SMMC-7721 cell apoptosis via caspase-3/vimentin signal-mediated EMT
Wei Y, Lv B, Xie J, Zhang Y, Lin Y, Wang S, Zhong J, Chen Y, Peng Y, Ma J
Drug Design, Development and Therapy 2019, 13:2343-2355
Published Date: 15 July 2019
Lycopene protects against myocardial ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
Li X, Jia P, Huang Z, Liu S, Miao J, Guo Y, Wu N, Jia D
Drug Design, Development and Therapy 2019, 13:2331-2342
Published Date: 11 July 2019
Efficacy and safety of cyclosporine A in the treatment of idiopathic membranous nephropathy in an Asian population
Lin S, Li HY, Zhou T, Lin W
Drug Design, Development and Therapy 2019, 13:2305-2330
Published Date: 11 July 2019
Differences in tolerability of pirfenidone between elderly and younger patients with idiopathic pulmonary fibrosis
Sakayori M, Terada J, Abe M, Hirasawa Y, Suzuki K, Yoshioka K, Tsushima K, Tatsumi K
Drug Design, Development and Therapy 2019, 13:2295-2303
Published Date: 11 July 2019
Comparative study of β-cyclodextrin, γ-cyclodextrin and 4-tert-butylcalix[8]arene ionophores as electroactive materials for the construction of new sensors for trazodone based on host-guest recognition
Alrabiah H, Aljohar HI, Bakheit AH, Homoda AMA, Mostafa GAH
Drug Design, Development and Therapy 2019, 13:2283-2293
Published Date: 11 July 2019
Durability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected subjects
Giacomelli A, Ranzani A, Oreni L, Gervasi E, Lupo A, Ridolfo AL, Galli M, Rusconi S
Drug Design, Development and Therapy 2019, 13:2271-2282
Published Date: 9 July 2019
The protective effect and mechanism of the FXR agonist obeticholic acid via targeting gut microbiota in non-alcoholic fatty liver disease
Zhang DY, Zhu L, Liu HN, Tseng YJ, Weng SQ, Liu TT, Dong L, Shen XZ
Drug Design, Development and Therapy 2019, 13:2249-2270
Published Date: 5 July 2019
Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/β-catenin signaling pathway and epithelial–mesenchymal transition
Wang P, Gao XY, Yang SQ, Sun ZX, Dian LL, Qasim M, Phyo AT, Liang ZS, Sun YF
Drug Design, Development and Therapy 2019, 13:2235-2247
Published Date: 8 July 2019
Immune-related adverse events following administration of anti-cytotoxic T-lymphocyte-associated protein-4 drugs: a comprehensive systematic review and meta-analysis
Xu H, Tan P, Zheng X, Huang Y, Lin T, Wei Q, Ai J, Yang L
Drug Design, Development and Therapy 2019, 13:2215-2234
Published Date: 4 July 2019
Delivery of folic acid-modified liposomal curcumin for targeted cervical carcinoma therapy
Wang WY, Cao YX, Zhou X, Wei B
Drug Design, Development and Therapy 2019, 13:2205-2213
Published Date: 4 July 2019
Activation of the P38/CREB/MMP13 axis is associated with osteoarthritis
Ji B, Ma Y, Wang H, Fang X, Shi P
Drug Design, Development and Therapy 2019, 13:2195-2204
Published Date: 3 July 2019
Tablet or capsule form of generic mycophenolate mofetil (My-Rept®) after liver transplantation: a prospective randomized trial
Kim JM, Oh JW, Kim S, Rhu J, Lee JS, Kim KS, Choi GS, Joh JW
Drug Design, Development and Therapy 2019, 13:2187-2193
Published Date: 2 July 2019
Efficacy and safety of tacrolimus vs cyclophosphamide in the therapy of patients with idiopathic membranous nephropathy: a meta-analysis
Lin W, Li HY, Lin S, Zhou T
Drug Design, Development and Therapy 2019, 13:2179-2186
Published Date: 3 July 2019
Evaluation of novel pyrimidine derivatives as a new class of mushroom tyrosinase inhibitor
Mirmortazavi SS, Farvandi M, Ghafouri H, Mohammadi A, Shourian M
Drug Design, Development and Therapy 2019, 13:2169-2178
Published Date: 8 July 2019
Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway
Zhang H, Han D, Lv T, Liu K, Yang Y, Xu X, Chen Y
Drug Design, Development and Therapy 2019, 13:2153-2167
Published Date: 2 July 2019
Preemptive analgesia after lumbar spine surgery by pregabalin and celecoxib: a prospective study
Kien NT, Geiger P, Van Chuong H, Cuong NM, Van Dinh N, Pho DC, Anh VT, Giang NT
Drug Design, Development and Therapy 2019, 13:2145-2152
Published Date: 3 July 2019
Role of GRP78 inhibiting artesunate-induced ferroptosis in KRAS mutant pancreatic cancer cells
Wang K, Zhang Z, Wang M, Cao X, Qi J, Wang D, Gong A, Zhu H
Drug Design, Development and Therapy 2019, 13:2135-2144
Published Date: 2 July 2019
Ginsenoside Rb1 pretreatment reverses hippocampal changes in BDNF/TrkB mRNA and protein in rats subjected to acute immobilization stress
Kang X, Hong W, Xie K, Tang H, Tang J, Luo S, Geng W, Jia D
Drug Design, Development and Therapy 2019, 13:2127-2134
Published Date: 1 July 2019
Effect of tumor necrosis factor inhibitors on interstitial lung disease in rheumatoid arthritis: angel or demon?
Huang Y, Lin W, Chen Z, Wang Y, Huang Y, Tu S
Drug Design, Development and Therapy 2019, 13:2111-2125
Published Date: 1 July 2019
Impact of different emulsifiers on biocompatibility and inflammatory potential of Perfluorohexyloctane (F6H8) emulsions for new intravenous drug delivery systems
Tsagogiorgas C, Anger F, Beck G, Breedijk A, Yard B, Hoeger S
Drug Design, Development and Therapy 2019, 13:2097-2110
Published Date: 27 June 2019
Phosphocreatine attenuates Gynura segetum-induced hepatocyte apoptosis via a SIRT3-SOD2-mitochondrial reactive oxygen species pathway
Li DP, Chen YL, Jiang HY, Chen Y, Zeng XQ, Xu LL, Ye Y, Ke CQ, Lin G, Wang JY, Gao H
Drug Design, Development and Therapy 2019, 13:2081-2096
Published Date: 27 June 2019
Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity via downregulation of Stathmin 1
Tan Y, Bi X, Wang Q, Li Y, Zhang N, Lao J, Liu X
Drug Design, Development and Therapy 2019, 13:2067-2079
Published Date: 3 July 2019
Ginsenoside Rg3 protects mouse leydig cells against triptolide by downregulation of miR-26a
Liang H, Zhang S, Li Z
Drug Design, Development and Therapy 2019, 13:2057-2066
Published Date: 24 June 2019
In vitro and in vivo effect of hyaluronic acid modified, doxorubicin and gallic acid co-delivered lipid-polymeric hybrid nano-system for leukemia therapy
Shao Y, Luo W, Guo Q, Li X, Zhang Q, Li J
Drug Design, Development and Therapy 2019, 13:2043-2055
Published Date: 28 June 2019
A novel mutation panel for predicting etoposide resistance in small-cell lung cancer
Qiu Z, Lin A, Li K, Lin W, Wang Q, Wei T, Zhu W, Luo P, Zhang J
Drug Design, Development and Therapy 2019, 13:2021-2041
Published Date: 21 June 2019
RETRACTED ARTICLE: TMF inhibits miR-29a/Wnt/β-catenin signaling through upregulating Foxo3a activity in osteoarthritis chondrocytes
Huang X, Chen Z, Shi W, Zhang R, Li L, Liu H, Wu L
Drug Design, Development and Therapy 2019, 13:2009-2019
Published Date: 19 June 2019
A study of refractory cases of persistent epithelial defects associated with dry eye syndrome and recurrent corneal erosions successfully treated with cyclosporine A 0.05% eye drops
Napoli PE, Braghiroli M, Iovino C, Demarinis G, Fossarello M
Drug Design, Development and Therapy 2019, 13:2001-2008
Published Date: 19 June 2019
Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis
Yang EJ, Smith MP, Ly K, Bhutani T
Drug Design, Development and Therapy 2019, 13:1993-2000
Published Date: 18 June 2019
A comparative double-blind randomized study on the effectiveness of Duloxetine and Gabapentin on painful diabetic peripheral polyneuropathy
Majdinasab N, Kaveyani H, Azizi M
Drug Design, Development and Therapy 2019, 13:1985-1992
Published Date: 17 June 2019
Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis
Huang Y, Wang H, Chen Z, Wang Y, Qin K, Huang Y, Ba X, Lin W, Tu S
Drug Design, Development and Therapy 2019, 13:1969-1984
Published Date: 17 June 2019
The neuroprotective effect of bisperoxovandium (pyridin-2-squaramide) in intracerebral hemorrhage
Liao XY, Lei Y, Chen SF, Cheng J, Zhao D, Zhang ZF, Han X, Zhang Y, Liao HB, Zhuang Y, Chen J, Zhou HB, Wan Q, Zou YY
Drug Design, Development and Therapy 2019, 13:1957-1967
Published Date: 13 June 2019
Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein
Ding P, Chen Y, Cao G, Shen H, Ju J, Li W
Drug Design, Development and Therapy 2019, 13:1947-1956
Published Date: 7 June 2019
The effect of etomidate or propofol on brainstem function during anesthesia induction: a bispectral index-guided study
Zheng H, Zhu Y, Chen K, Shen X
Drug Design, Development and Therapy 2019, 13:1941-1946
Published Date: 5 June 2019
Notopterol-induced apoptosis and differentiation in human acute myeloid leukemia HL-60 cells
Huang Q, Wang L, Ran Q, Wang J, Wang C, He H, Li L, Qi H
Drug Design, Development and Therapy 2019, 13:1927-1940
Published Date: 6 June 2019
Decreased sEng plasma levels in hypertensive patients with endothelial dysfunction under chronic treatment with Perindopril
Buda V, Andor M, Baibata DE, Cozlac R, Radu G, Coricovac D, Danciu C, Ledeti I, Cheveresan A, Nica C, Tuduce P, Tomescu MC
Drug Design, Development and Therapy 2019, 13:1915-1925
Published Date: 4 June 2019
Effects of Qi Teng Xiao Zhuo granules on circRNA expression profiles in rats with chronic glomerulonephritis
Gao JR, Jiang NN, Jiang H, Wei LB, Gao YC, Qin XJ, Zhu MQ, Wang J
Drug Design, Development and Therapy 2019, 13:1901-1913
Published Date: 4 June 2019
Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways
Wang R, Song F, Li S, Wu B, Gu Y, Yuan Y
Drug Design, Development and Therapy 2019, 13:1889-1900
Published Date: 31 May 2019
15-Deoxy-Δ12,14-prostaglandin J2 as a potential regulator of bone metabolism via PPARγ-dependent and independent pathways: a review
Xiong Z, Luo P, Zhou J, Tan M
Drug Design, Development and Therapy 2019, 13:1879-1888
Published Date: 30 May 2019
Efficacy and toxicity of cladribine for the treatment of refractory acute myeloid leukemia: a meta-analysis
Zhou A, Han Q, Song H, Zi J, Ma J, Ge Z
Drug Design, Development and Therapy 2019, 13:1867-1878
Published Date: 29 May 2019
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress [Corrigendum]
Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y
Drug Design, Development and Therapy 2019, 13:1865-1866
Published Date: 29 May 2019
Comparative proteomics reveal negative effects of gonadotropin-releasing hormone agonist and antagonist on human endometrium
Chen Q, Yu F, Li Y, Zhang AJ, Zhu XB
Drug Design, Development and Therapy 2019, 13:1855-1863
Published Date: 30 May 2019
Resveratrol downregulates TNF-α-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling
Lin JW, Yang LH, Ren ZC, Mu DG, Li YQ, Yan JP, Wang LX, Chen C
Drug Design, Development and Therapy 2019, 13:1843-1853
Published Date: 27 May 2019
Use of lidocaine to prevent postoperative coughing after partial laryngectomy: comparison of three delivery methods
Wang Y, Lu WS, Qiao H, Zhao J, Fan Q
Drug Design, Development and Therapy 2019, 13:1835-1841
Published Date: 27 May 2019
A novel non-invasive monitoring assay of 5-azacitidine efficacy using global DNA methylation of peripheral blood in myelodysplastic syndrome
Asano M, Ohyashiki JH, Kobayashi-Kawana C, Umezu T, Imanishi S, Azuma K, Akahane D, Fujimoto H, Ito Y, Ohyashiki K
Drug Design, Development and Therapy 2019, 13:1821-1833
Published Date: 30 May 2019
Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-β/Smad signaling pathway [Corrigendum]
Mu M, Zuo S, Wu RM, Deng KS, Lu S, Zhu JJ, Zou GL, Yang J, Cheng ML, Zhao XK
Drug Design, Development and Therapy 2019, 13:1819-1820
Published Date: 24 May 2019
Frequency, clinical features and differential response to therapy of concurrent ALK/EGFR alterations in Chinese lung cancer patients
Liu J, Mu Z, Liu L, Li K, Jiang R, Chen P, Zhou Q, Jin M, Ma Y, Xie Y, Xiang J, Li B, Ma Y, Mao X, Zhang L, Zhang T, Wu D
Drug Design, Development and Therapy 2019, 13:1809-1817
Published Date: 23 May 2019
Effect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial
Miao S, Zou L, Wang G, Wang X, Liu S, Shi M
Drug Design, Development and Therapy 2019, 13:1803-1808
Published Date: 27 May 2019
Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts
Saeed M, Arun MZ, Guzeloglu M, Onursal C, Gokce G, Korkmaz CG, Reel B
Drug Design, Development and Therapy 2019, 13:1791-1801
Published Date: 23 May 2019
Synthesis, comparative docking, and pharmacological activity of naproxen amino acid derivatives as possible anti-inflammatory and analgesic agents
Elhenawy AA, Al-Harbi LM, Moustafa GO, El-Gazzar MA, Abdel-Rahman RF, Salim AE
Drug Design, Development and Therapy 2019, 13:1773-1790
Published Date: 24 May 2019
SU5416 attenuated lipopolysaccharide-induced acute lung injury in mice by modulating properties of vascular endothelial cells
Huang X, Zhu J, Jiang Y, Xu C, Lv Q, Yu D, Shi K, Ruan Z, Wang Y
Drug Design, Development and Therapy 2019, 13:1763-1772
Published Date: 23 May 2019
Population pharmacokinetic analysis of tramadol and O-desmethyltramadol with genetic polymorphism of CYP2D6
Lee J, Yoo H, Bae JW, Lee S, Shin K
Drug Design, Development and Therapy 2019, 13:1751-1761
Published Date: 23 May 2019
Bioequivalence of paclitaxel protein-bound particles in patients with breast cancer: determining total and unbound paclitaxel in plasma by rapid equilibrium dialysis and liquid chromatography–tandem mass spectrometry
Li J, Li W, Dai X, Zhong D, Ding Y, Chen X
Drug Design, Development and Therapy 2019, 13:1739-1749
Published Date: 20 May 2019
The effect of midazolam administration for the prevention of emergence agitation in pediatric patients with extreme fear and non-cooperation undergoing dental treatment under sevoflurane anesthesia, a double-blind, randomized study
Kawai M, Kurata S, Sanuki T, Mishima G, Kiriishi K, Watanabe T, Ozaki-Honda Y, Yoshida M, Okayasu I, Ayuse T, Tanoue N, Ayuse T
Drug Design, Development and Therapy 2019, 13:1729-1737
Published Date: 17 May 2019
Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy
Yee J, Kim W, Chang BC, Chung JE, Lee KE, Gwak HS
Drug Design, Development and Therapy 2019, 13:1717-1727
Published Date: 17 May 2019
Subcutaneous bortezomib might be standard of care for patients with multiple myeloma: a systematic review and meta-analysis
Ye Z, Chen J, Xuan Z, Yang W, Chen J
Drug Design, Development and Therapy 2019, 13:1707-1716
Published Date: 16 May 2019
Sevoflurane post-conditioning alleviates neonatal rat hypoxic-ischemic cerebral injury via Ezh2-regulated autophagy
Xue H, Xu Y, Wang S, Wu ZY, Li XY, Zhang YH, Niu JY, Gao QS, Zhao P
Drug Design, Development and Therapy 2019, 13:1691-1706
Published Date: 15 May 2019
Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis [Corrigendum]
Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K
Drug Design, Development and Therapy 2019, 13:1689-1690
Published Date: 22 May 2019
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Response to letter]
Abe M, Tsushima K, Tatsumi K
Drug Design, Development and Therapy 2019, 13:1687-1688
Published Date: 14 May 2019
Cardiovascular adverse events during treatment with darunavir-based regimens in an Italian observational study
Antinori A, Rusconi S, Gianotti N, Bini T, Mancusi D, Termini R
Drug Design, Development and Therapy 2019, 13:1667-1685
Published Date: 14 May 2019
Andrographolide attenuates bupivacaine-induced cytotoxicity in SH-SY5Y cells through preserving Akt/mTOR activity
Zhang H, Wang W, Du Q
Drug Design, Development and Therapy 2019, 13:1659-1666
Published Date: 16 May 2019
Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation
Ashraf Z, Mahmood T, Hassan M, Afzal S, Rafique H, Afzal K, Latip J
Drug Design, Development and Therapy 2019, 13:1643-1657
Published Date: 14 May 2019
Effect of pravastatin treatment on circulating adiponectin: a meta-analysis of randomized controlled trials
Shu X, Chi L
Drug Design, Development and Therapy 2019, 13:1633-1641
Published Date: 13 May 2019
Pharmacokinetics of fixed-dose combination of atorvastatin and metformin compared with individual tablets
Ghim JL, Phuong NTT, Kim MJ, Kim EJ, Song GS, Ahn S, Shin JG, Kim EY
Drug Design, Development and Therapy 2019, 13:1623-1632
Published Date: 13 May 2019
6,7-Dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway
Chiu CF, Lai GY, Chen CH, Chiu CC, Hung SW, Chang CF
Drug Design, Development and Therapy 2019, 13:1609-1621
Published Date: 9 May 2019
Comparison of the efficacy and safety of remifentanil versus different pharmacological approaches on prevention of etomidate-induced myoclonus: a meta-analysis of randomized controlled trials
Lang B, Zhang L, Li F, Lin Y, Zhang W, Yang C
Drug Design, Development and Therapy 2019, 13:1593-1607
Published Date: 9 May 2019
Extending the application of a magnetic PEG three-part drug release device on a graphene substrate for the removal of Gram-positive and Gram-negative bacteria and cancerous and pathologic cells
Ramezani Farani M, Khadive Parsi P, Riazi Gh, Shafiee Ardestani M, Saligheh Rad H
Drug Design, Development and Therapy 2019, 13:1581-1591
Published Date: 10 May 2019
Formulation and evaluation of simvastatin polymeric nanoparticles loaded in hydrogel for optimum wound healing purpose
Farghaly Aly U, Abou-Taleb HA, Abdellatif AH, Sameh Tolba N
Drug Design, Development and Therapy 2019, 13:1567-1580
Published Date: 10 May 2019
Protective effects of five compounds from Livistona chinensis R. Brown leaves against hypoxia/reoxygenation, H2O2, or adriamycin-induced injury in H9c2 cells
Li S, Luo S, Chen H, Zheng Y, Lin L, Yao H, Lin X
Drug Design, Development and Therapy 2019, 13:1555-1566
Published Date: 8 May 2019
Glibenclamide alleviates inflammation in oleic acid model of acute lung injury through NLRP3 inflammasome signaling pathway
Chen H, Ding Y, Chen W, Feng Y, Shi G
Drug Design, Development and Therapy 2019, 13:1545-1554
Published Date: 7 May 2019
Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date
Felten R, Scher F, Sagez F, Chasset F, Arnaud L
Drug Design, Development and Therapy 2019, 13:1535-1543
Published Date: 8 May 2019
Dabigatran must be used carefully: literature review and recommendations for management of adverse events
Lin S, Wang Y, Zhang L, Guan W
Drug Design, Development and Therapy 2019, 13:1527-1533
Published Date: 6 May 2019
Inotersen: new promise for the treatment of hereditary transthyretin amyloidosis
Mathew V, Wang AK
Drug Design, Development and Therapy 2019, 13:1515-1525
Published Date: 6 May 2019
In silico and in vitro studies of lupeol and iso-orientin as potential antidiabetic agents in a rat model
Malik A, Jamil U, Butt TT, Waquar S, Gan SH, Shafique H, Jafar TH
Drug Design, Development and Therapy 2019, 13:1501-1513
Published Date: 6 May 2019
Safety evaluation and cardiovascular effect of additional use of spironolactone in hemodialysis patients: a meta-analysis
Zeng Q, Zhou X, Xu G
Drug Design, Development and Therapy 2019, 13:1487-1499
Published Date: 3 May 2019
Resveratrol reduces liver endoplasmic reticulum stress and improves insulin sensitivity in vivo and in vitro
Zhao H, Zhang Y, Shu L, Song G, Ma H
Drug Design, Development and Therapy 2019, 13:1473-1485
Published Date: 2 May 2019
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress
Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y
Drug Design, Development and Therapy 2019, 13:1461-1472
Published Date: 1 May 2019
Isobavachalcone isolated from Psoralea corylifolia inhibits cell proliferation and induces apoptosis via inhibiting the AKT/GSK-3β/β-catenin pathway in colorectal cancer cells
Li Y, Qin X, Li P, Zhang H, Lin T, Miao Z, Ma S
Drug Design, Development and Therapy 2019, 13:1449-1460
Published Date: 1 May 2019
Tetramethylpyrazine improved the survival of multiterritory perforator flaps by inducing angiogenesis and suppressing apoptosis via the Akt/Nrf2 pathway
Qing L, Wu P, Zhou Z, Yu F, Tang J
Drug Design, Development and Therapy 2019, 13:1437-1447
Published Date: 1 May 2019
Enhanced immunosuppressive effects of 3,5-bis[4(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, an α, β-unsaturated carbonyl-based compound as PLGA-b-PEG nanoparticles
Arshad L, Jantan I, Bukhari SNA
Drug Design, Development and Therapy 2019, 13:1421-1436
Published Date: 30 April 2019
Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization
Naglah AM, Refat MS, Al-Omar MA, Bhat MA, AlKahtani HM, Al-Wasidi AS
Drug Design, Development and Therapy 2019, 13:1409-1420
Published Date: 30 April 2019
Combination of drugs and carriers in drug delivery technology and its development
Du Y, Chen B
Drug Design, Development and Therapy 2019, 13:1401-1408
Published Date: 30 April 2019
Nicorandil prior to primary percutaneous coronary intervention improves clinical outcomes in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials
Xu L, Wang L, Li K, Zhang Z, Sun H, Yang X
Drug Design, Development and Therapy 2019, 13:1389-1400
Published Date: 29 April 2019
The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP
Huang Q, Peng Y, Peng Y, Wei D, Wei Y, Feng S
Drug Design, Development and Therapy 2019, 13:1373-1388
Published Date: 26 April 2019
Codelivery of GRP78 siRNA and docetaxel via RGD-PEG-DSPE/DOPA/CaP nanoparticles for the treatment of castration-resistant prostate cancer
Zhang X, He Z, Xiang L, Li L, Zhang H, Lin F, Cao H
Drug Design, Development and Therapy 2019, 13:1357-1372
Published Date: 29 April 2019
Clinical efficacy of 60-mg dexlansoprazole and 40-mg esomeprazole after 24 weeks for the on-demand treatment of gastroesophageal reflux disease grades A and B: a prospective randomized trial
Chiang HH, Wu DC, Hsu PI, Kuo CH, Tai WC, Yang SC, Wu KL, Yao CC, Tsai CE, Liang CM, Wang YK, Wang JW, Huang CF, Chuah SK
Drug Design, Development and Therapy 2019, 13:1347-1356
Published Date: 26 April 2019
Caffeic acid phenethyl ester suppressed growth and metastasis of nasopharyngeal carcinoma cells by inactivating the NF-κB pathway
Liang Y, Feng G, Wu L, Zhong S, Gao X, Tong Y, Cui W, Qin Y, Xu WQ, Xiao X, Zhang Z, Huang G, Zhou X
Drug Design, Development and Therapy 2019, 13:1335-1345
Published Date: 26 April 2019
Ocular surface squamous neoplasia: angiographic characteristics and response to subconjunctival/perilesional 5-fluorouracil injections
Sun Y, Hua R
Drug Design, Development and Therapy 2019, 13:1323-1334
Published Date: 29 April 2019
Epigallocatechin-3-gallate enhances the osteoblastogenic differentiation of human adipose-derived stem cells
Zhang J, Wu K, Xu T, Wu J, Li P, Wang H, Wu H, Wu G
Drug Design, Development and Therapy 2019, 13:1311-1321
Published Date: 23 April 2019
Safety and sedative effect of intranasal dexmedetomidine in mandibular third molar surgery: a systematic review and meta-analysis
Liu S, Wang Y, Zhu Y, Yu T, Zhao H
Drug Design, Development and Therapy 2019, 13:1301-1310
Published Date: 23 April 2019
Plumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA
Li T, Lv M, Chen X, Yu Y, Zang G, Tang Z
Drug Design, Development and Therapy 2019, 13:1289-1300
Published Date: 23 April 2019
Effects of dezocine for the prevention of postoperative catheter-related bladder discomfort: a prospective randomized trial
Zhang GF, Guo J, Qiu LL, Li SM, Zheng M, Xia JY, Yang JJ
Drug Design, Development and Therapy 2019, 13:1281-1288
Published Date: 23 April 2019
Anti-tumor efficacy of folate modified PLGA-based nanoparticles for the co-delivery of drugs in ovarian cancer
Li S, Li X, Ding J, Han L, Guo X
Drug Design, Development and Therapy 2019, 13:1271-1280
Published Date: 18 April 2019
Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates
Reisman SA, Gahir SS, Lee CY, Proksch JW, Sakamoto M, Ward KW
Drug Design, Development and Therapy 2019, 13:1259-1270
Published Date: 17 April 2019
Caplacizumab as an emerging treatment option for acquired thrombotic thrombocytopenic purpura
Elverdi T, Eskazan AE
Drug Design, Development and Therapy 2019, 13:1251-1258
Published Date: 17 April 2019
In vitro comparative quality assessment of different brands of norfloxacin tablets available in Jimma, Southwest Ethiopia
Hambisa S, Belew S, Suleman S
Drug Design, Development and Therapy 2019, 13:1241-1249
Published Date: 17 April 2019
Effect of loading dose of atorvastatin therapy prior to percutaneous coronary intervention in patients with acute coronary syndrome: a meta-analysis of six randomized controlled trials
Ma M, Bu L, Shi L, Guo R, Yang B, Cao H, Luo L, Lu L
Drug Design, Development and Therapy 2019, 13:1233-1240
Published Date: 16 April 2019
The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1
Tao H, Tang T, Wang S, Wang Z, Ma Y, Cai T, Cheng X, Qi S, Zhang Y, Qi Z
Drug Design, Development and Therapy 2019, 13:1221-1231
Published Date: 17 April 2019
Effect of butorphanol on etomidate-induced myoclonus: a systematic review and meta-analysis
Hua J, Miao S, Shi M, Tu Q, Wang X, Liu S, Wang G, Gan J
Drug Design, Development and Therapy 2019, 13:1213-1220
Published Date: 16 April 2019
Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease
Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL
Drug Design, Development and Therapy 2019, 13:1197-1211
Published Date: 17 April 2019
Tetramethylpyrazine attenuated bupivacaine-induced neurotoxicity in SH-SY5Y cells through regulating apoptosis, autophagy and oxidative damage
Wang S, Xia B, Qiao Z, Duan L, Wang G, Meng W, Liu Z, Wang Y, Zhang M
Drug Design, Development and Therapy 2019, 13:1187-1196
Published Date: 17 April 2019
Antileishmanial and antitrypanosomal activity of symmetrical dibenzyl-substituted α,β-unsaturated carbonyl-based compounds
Alkhaldi AAM, de Koning HP, Bukhari SNA
Drug Design, Development and Therapy 2019, 13:1179-1185
Published Date: 24 April 2019
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Letter]
Orsatti L, Fortea J, Quaresma M
Drug Design, Development and Therapy 2019, 13:1177-1178
Published Date: 12 April 2019
Comparison of dexmedetomidine and sufentanil as adjuvants to local anesthetic for epidural labor analgesia: a randomized controlled trial
Zhang T, Yu Y, Zhang W, Zhu J
Drug Design, Development and Therapy 2019, 13:1171-1175
Published Date: 11 April 2019
Effect of umbelliferone on adjuvant-induced arthritis in rats by MAPK/NF-κB pathway
Ouyang L, Dan Y, Shao Z, Yang S, Yang C, Liu G, Zhou W, Duan D
Drug Design, Development and Therapy 2019, 13:1163-1170
Published Date: 11 April 2019
Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation
Abdel-Wahab WM, Moussa FI
Drug Design, Development and Therapy 2019, 13:1155-1162
Published Date: 11 April 2019
Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo
Chen S, Zhang Z, Zhang J
Drug Design, Development and Therapy 2019, 13:1145-1153
Published Date: 10 April 2019
The neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1α in cerebral ischemia-reperfusion injury
Hou Y, Wang J, Feng J
Drug Design, Development and Therapy 2019, 13:1135-1144
Published Date: 9 April 2019
Low-dose adefovir dipivoxil–induced hypophosphatemia osteomalacia in five chronic hepatitis B virus–infected patients. Is low-dose adefovir dipivoxil–induced nephrotoxicity completely reversible?
Qian YY, Dai ZJ, Ruan LY, Pan YJ, Jin J, Shi MT, Zhu YX, Wu CM
Drug Design, Development and Therapy 2019, 13:1127-1133
Published Date: 10 April 2019
Quizartinib (AC220): a promising option for acute myeloid leukemia
Zhou F, Ge Z, Chen B
Drug Design, Development and Therapy 2019, 13:1117-1125
Published Date: 8 April 2019
Applications of daunorubicin-loaded PLGA-PLL-PEG-Tf nanoparticles in hematologic malignancies: an in vitro and in vivo evaluation
Bao W, Liu R, Xia G, Wang F, Chen B
Drug Design, Development and Therapy 2019, 13:1107-1115
Published Date: 8 April 2019
Can a cyclooxygenase inhibitor be an option for treatment of ovarian hyperstimulation syndrome?
Çilgin H
Drug Design, Development and Therapy 2019, 13:1099-1105
Published Date: 5 April 2019
Lung cancer combination therapy: doxorubicin and β-elemene co-loaded, pH-sensitive nanostructured lipid carriers
Cao C, Wang Q, Liu Y
Drug Design, Development and Therapy 2019, 13:1087-1098
Published Date: 5 April 2019
A novel hybrid compound LLP2A-alendronate accelerates open fracture healing in a rabbit model
Wang Z, Zhao Y, Zhang D, Qi B, Xiao W, Hu X, Yu A
Drug Design, Development and Therapy 2019, 13:1077-1086
Published Date: 5 April 2019
Systematic elucidation of the mechanism of geraniol via network pharmacology
Zhang YF, Huang Y, Ni YH, Xu ZM
Drug Design, Development and Therapy 2019, 13:1069-1075
Published Date: 4 April 2019
Transportan-derived cell-penetrating peptide delivers siRNA to inhibit replication of influenza virus in vivo
Zhang C, Ren W, Liu Q, Tan Z, Li J, Tong C
Drug Design, Development and Therapy 2019, 13:1059-1068
Published Date: 4 April 2019
Formulation and bioequivalence studies of choline alfoscerate tablet comparing with soft gelatin capsule in healthy male volunteers
Min MH, Park JH, Hur JH, Shin HC, Cho YJ, Kim DD
Drug Design, Development and Therapy 2019, 13:1049-1058
Published Date: 5 April 2019
Metabolism of remimazolam in primary human hepatocytes during continuous long-term infusion in a 3-D bioreactor system
Freyer N, Knöspel F, Damm G, Greuel S, Schneider C, Seehofer D, Stöhr T, Petersen KU, Zeilinger K
Drug Design, Development and Therapy 2019, 13:1033-1047
Published Date: 2 April 2019
Jinlong capsule inhibits migration and invasion in human glioblastoma cells via the modulation of mTOR/S6 signaling pathway
Shi J, Zhang W, He L, Kong F, Pan M, Guo J, Xu X, Guo J, Wang H, Wang Y
Drug Design, Development and Therapy 2019, 13:1023-1032
Published Date: 1 April 2019
A first-in-human study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of KM-819 (FAS-associated factor 1 inhibitor), a drug for Parkinson’s disease, in healthy volunteers
Shin W, Lim KS, Kim MK, Kim HS, Hong J, Jhee S, Kim J, Yoo S, Chung YT, Lee JM, Cho DY
Drug Design, Development and Therapy 2019, 13:1011-1022
Published Date: 29 March 2019
Efficacy and safety of paricalcitol in patients undergoing hemodialysis: a meta-analysis
Liu Y, Liu LY, Jia Y, Wu MY, Sun YY, Ma FZ
Drug Design, Development and Therapy 2019, 13:999-1009
Published Date: 28 March 2019
Pharmacokinetic comparison of a fixed-dose combination versus concomitant administration of amlodipine, olmesartan, and rosuvastatin in healthy adult subjects
Oh M, Shin JG, Ahn S, Kim BH, Kim JY, Shin HJ, Shin HJ, Ghim JL
Drug Design, Development and Therapy 2019, 13:991-997
Published Date: 3 April 2019
Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes
Ye B, Chen X, Dai S, Han J, Liang X, Lin S, Cai X, Huang Z, Huang W
Drug Design, Development and Therapy 2019, 13:975-990
Published Date: 25 March 2019
Effectiveness and safety of intravenous application of dexmedetomidine for cesarean section under general anesthesia: a meta-analysis of randomized trials
Ao L, Shi J, Bai Y, Zheng Y, Gan J
Drug Design, Development and Therapy 2019, 13:965-974
Published Date: 25 March 2019
Single- and multiple-dose tolerability, safety, pharmacokinetics, and pharmacodynamics of the dual endothelin receptor antagonist aprocitentan in healthy adult and elderly subjects
Sidharta PN, Melchior M, Kankam MK, Dingemanse J
Drug Design, Development and Therapy 2019, 13:949-964
Published Date: 22 March 2019
Increased branching and sialylation of N-linked glycans correlate with an improved pharmacokinetic profile for BAY 81–8973 compared with other full-length rFVIII products
Teare JM, Kates DS, Shah A, Garger S
Drug Design, Development and Therapy 2019, 13:941-948
Published Date: 22 March 2019
Hexyl alginate derivative, an amphiphilic innovative buccal film-forming material of promising mechanical and release characteristics for the improvement of repaglinide bioavailability
Khames A
Drug Design, Development and Therapy 2019, 13:925-940
Published Date: 21 March 2019
Mechanistic research holds promise for bacterial vaccines and phage therapies for Pseudomonas aeruginosa
Hoggarth A, Weaver A, Pu Q, Huang T, Schettler J, Chen F, Yuan X, Wu M
Drug Design, Development and Therapy 2019, 13:909-924
Published Date: 20 March 2019
Protective role of quercetin against manganese-induced injury in the liver, kidney, and lung; and hematological parameters in acute and subchronic rat models [Retraction]
Bahar E, Lee GH, Bhattarai KR, Lee HY, Kim HK, Handigund M, Choi MK, Han SY, Chae HJ, Yoon H
Drug Design, Development and Therapy 2019, 13:907-908
Published Date: 18 March 2019
Dexmedetomidine for the prevention of emergence delirium and postoperative behavioral changes in pediatric patients with sevoflurane anesthesia: a double-blind, randomized trial
Shi M, Miao S, Gu T, Wang D, Zhang H, Liu J
Drug Design, Development and Therapy 2019, 13:897-905
Published Date: 15 March 2019
Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis
Huang H, Liu H, Zhou H, Liang Z, Song D, Zhang Y, Huang W, Zhao X, Wu B, Ye G, Huang Y
Drug Design, Development and Therapy 2019, 13:881-896
Published Date: 12 March 2019
Intraoperative dexmedetomidine infusion is associated with reduced emergence agitation and improved recovery profiles after lung surgery: a retrospective cohort study
Kang X, Tang X, Yu Y, Bao F, Gan S, Zheng W, Zhang J, Zhu S
Drug Design, Development and Therapy 2019, 13:871-879
Published Date: 12 March 2019
Efficacy and safety of tacrolimus in induction therapy of patients with lupus nephritis
Zhou TB, Lin SJ, Yang S, Lin WS
Drug Design, Development and Therapy 2019, 13:857-869
Published Date: 12 March 2019
Clinical efficacy and safety of rituximab in lupus nephritis
Zhong Z, Li H, Zhong H, Zhou T
Drug Design, Development and Therapy 2019, 13:845-856
Published Date: 11 March 2019
Chronic myelogenous leukemia, a still unsolved problem: pitfalls and new therapeutic possibilities
Flis S, Chojnacki T
Drug Design, Development and Therapy 2019, 13:825-843
Published Date: 8 March 2019
The journey from gene knockout to clinical medicine: telotristat and sotagliflozin
Rendell MS
Drug Design, Development and Therapy 2019, 13:817-824
Published Date: 6 March 2019
Single-use suvorexant for treating insomnia during overnight polysomnography in patients with suspected obstructive sleep apnea: a single-center experience
Matsumura T, Terada J, Yoshimura C, Koshikawa K, Kinoshita T, Yahaba M, Nagashima K, Sakao S, Tatsumi K
Drug Design, Development and Therapy 2019, 13:809-816
Published Date: 28 February 2019
Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Corrigendum]
Abe M, Tsushima K, Sakayori M, Suzuki K, Ikari J, Terada J, Tatsumi K
Drug Design, Development and Therapy 2019, 13:807-808
Published Date: 28 February 2019
Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system
An Q, Zheng Y, Zhao Y, Liu T, Guo H, Zhang D, Qian W, Wang H, Guo Y, Hou S, Li J
Drug Design, Development and Therapy 2019, 13:791-805
Published Date: 12 March 2019
Synthesis, structure elucidation, and antifungal potential of certain new benzodioxole–imidazole molecular hybrids bearing ester functionalities
Al-Wabli RI, Al-Ghamdi AR, Ghabbour HA, Al-Agamy MH, Attia MI
Drug Design, Development and Therapy 2019, 13:775-789
Published Date: 26 February 2019
Ginkgolide B ameliorates myocardial ischemia reperfusion injury in rats via inhibiting endoplasmic reticulum stress
Guo C, Zhang J, Zhang P, Si A, Zhang Z, Zhao L, Lv F, Zhao G
Drug Design, Development and Therapy 2019, 13:767-774
Published Date: 26 February 2019
siRNA-based breast cancer therapy by suppressing 17β-hydroxysteroid dehydrogenase type 1 in an optimized xenograft cell and molecular biology model in vivo
Li F, Zhu ZH, Xue M, He WH, Zhang T, Feng LL, Lin SX
Drug Design, Development and Therapy 2019, 13:757-766
Published Date: 22 February 2019
Resveratrol attenuates hydrogen peroxide-induced aging through upregulation of autophagy in human umbilical vein endothelial cells
Du L, Chen E, Wu T, Ruan Y, Wu S
Drug Design, Development and Therapy 2019, 13:747-755
Published Date: 22 February 2019
Maresin 1 mitigates renal ischemia/reperfusion injury in mice via inhibition of the TLR4/MAPK/ NF-κB pathways and activation of the Nrf2 pathway
Qiu Y, Wu Y, Zhao H, Sun H, Gao S
Drug Design, Development and Therapy 2019, 13:739-745
Published Date: 20 February 2019
Profile of semaglutide in the management of type 2 diabetes: design, development, and place in therapy
Gomez-Peralta F, Abreu C
Drug Design, Development and Therapy 2019, 13:731-738
Published Date: 20 February 2019
Comparisons between ticagrelor and clopidogrel following percutaneous coronary intervention in patients with acute coronary syndrome: a comprehensive meta-analysis
Fan ZG, Zhang WL, Xu B, Ji J, Tian NL, He SH
Drug Design, Development and Therapy 2019, 13:719-730
Published Date: 20 February 2019
Monosialoganglioside protects against bupivacaine-induced neurotoxicity caused by endoplasmic reticulum stress in rats
Liu B, Ji J, Feng Q, Luo X, Yan X, Ni Y, He Y, Mao Z, Liu J
Drug Design, Development and Therapy 2019, 13:707-718
Published Date: 19 February 2019
Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways
Tu Y, Liang Y, Xiao Y, Lv J, Guan R, Xiao F, Xie Y, Xiao Q
Drug Design, Development and Therapy 2019, 13:695-706
Published Date: 19 February 2019
Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study
Yan Y, Wang P, Li R, Sun Y, Zhang R, Huo C, Xing J, Dong Y
Drug Design, Development and Therapy 2019, 13:681-694
Published Date: 19 February 2019
Update in treatment of uveitic macular edema
Koronis S, Stavrakas P, Balidis M, Kozeis N, Tranos PG
Drug Design, Development and Therapy 2019, 13:667-680
Published Date: 19 February 2019
Evaluation of pharmacokinetics and pharmacodynamics of sinomenine-hyaluronic acid conjugate after intra-articular administration for osteoarthritis treatment
Liu J, Shao H, Fang S, Cheng Y, Ling P, Chen J
Drug Design, Development and Therapy 2019, 13:657-665
Published Date: 15 February 2019
Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway
Chen X, Ren S, Dong J, Qiu C, Chen Y, Tao H
Drug Design, Development and Therapy 2019, 13:647-655
Published Date: 13 February 2019
Efficacy of a fixed dose combination of irbesartan and atorvastatin (Rovelito®) in Korean adults with hypertension and hypercholesterolemia
Ihm SH, Shin J, Park CG, Kim CH
Drug Design, Development and Therapy 2019, 13:633-645
Published Date: 13 February 2019
Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3β/β-catenin signal pathway
Zang D, Niu C, Aisa HA
Drug Design, Development and Therapy 2019, 13:623-632
Published Date: 12 February 2019
Epigallocatechin-3-gallate in the prevention and treatment of hepatocellular carcinoma: experimental findings and translational perspectives
Bimonte S, Albino V, Piccirillo M, Nasto A, Molino C, Palaia R, Cascella M
Drug Design, Development and Therapy 2019, 13:611-621
Published Date: 12 February 2019
Emodin induces apoptosis and autophagy of fibroblasts obtained from patient with ankylosing spondylitis
Ma C, Wen B, Zhang Q, Shao P, Gu W, Qu K, Shi Y, Wang B
Drug Design, Development and Therapy 2019, 13:601-609
Published Date: 11 February 2019
The underlying mechanisms of Jie-Du-Hua-Yu granule for protecting rat liver failure
Qiu H, Mao D, Tang N, Long F, Zhang R, Wang M, Shi Q, Li J, Jiang Q, Chen Y, Wang X
Drug Design, Development and Therapy 2019, 13:589-600
Published Date: 11 February 2019
Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis
Guo J, Tu J, Hu YY, Song GX, Yin ZQ
Drug Design, Development and Therapy 2019, 13:581-588
Published Date: 8 February 2019
Brigatinib for ALK-positive metastatic non-small-cell lung cancer: design, development and place in therapy
Ali R, Arshad J, Palacio S, Mudad R
Drug Design, Development and Therapy 2019, 13:569-580
Published Date: 8 February 2019
Efficacy of a recombinant single-chain fragment variable region, VasSF, as a new drug for vasculitis
Kameoka Y, Kishi F, Koura M, Yamakawa Y, Nagasawa R, Ito F, Matsuda J, Suzuki O, Nakayama T, Suzuki K
Drug Design, Development and Therapy 2019, 13:555-568
Published Date: 5 February 2019
The benefit of taxane-based therapies over fluoropyrimidine plus platinum (FP) in the treatment of esophageal cancer: a meta-analysis of clinical studies
Wang T, Yu J, Liu M, Chen Y, Zhu C, Lu L, Wang M, Min L, Liu X, Zhang X, Gubat JA, Chen Y
Drug Design, Development and Therapy 2019, 13:539-553
Published Date: 5 February 2019
Safety and efficacy of atezolizumab in the treatment of cancers: a systematic review and pooled-analysis
Tie Y, Yang H, Zhao R, Zheng H, Yang D, Zhao J, Liu M
Drug Design, Development and Therapy 2019, 13:523-538
Published Date: 4 February 2019
Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling
Tang Y, Li K, Yang C, Huang K, Zhou J, Shi Y, Xie K, Liu J
Drug Design, Development and Therapy 2019, 13:513-521
Published Date: 1 February 2019
Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3β pathway
Wang R, Zhang Z, Kumar M, Xu G, Zhang M
Drug Design, Development and Therapy 2019, 13:501-512
Published Date: 4 February 2019
Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways [Erratum]
Ren H, Li Y, Chen Y, Wang L
Drug Design, Development and Therapy 2019, 13:499-500
Published Date: 31 January 2019
Targeting the A3 adenosine receptor to treat cytokine release syndrome in cancer immunotherapy
Cohen S, Fishman P
Drug Design, Development and Therapy 2019, 13:491-497
Published Date: 30 January 2019
Model-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics
Faisal M, Cawello W, Burckhardt BB, Laer S
Drug Design, Development and Therapy 2019, 13:481-490
Published Date: 25 January 2019
A nucleoside-sparing regimen of dolutegravir plus ritonavir-boosted atazanavir in HIV-1-infected patients with virological failure: the DOLATAV study
Spagnuolo V, Galli L, Poli A, Bigoloni A, Fumagalli L, Gianotti N, Nozza S, Ferrari D, Locatelli M, Lazzarin A, Castagna A
Drug Design, Development and Therapy 2019, 13:477-479
Published Date: 24 January 2019
Qingxin kaiqiao fang ameliorates memory impairment and inhibits apoptosis in APP/PS1 double transgenic mice through the MAPK pathway
Gao SY, Lin J, Wang T, Shen Y, Li Y, Yang W, Zhou K, Hu H
Drug Design, Development and Therapy 2019, 13:459-475
Published Date: 23 January 2019
Structure–activity relationship of an antimicrobial peptide, Phylloseptin-PHa: balance of hydrophobicity and charge determines the selectivity of bioactivities
Liu Y, Du Q, Ma C, Xi X, Wang L, Zhou M, Burrows JF, Chen T, Wang H
Drug Design, Development and Therapy 2019, 13:447-458
Published Date: 23 January 2019
MicroRNA-339 inhibits human hepatocellular carcinoma proliferation and invasion via targeting ZNF689
Zeng H, Zheng J, Wen S, Luo J, Shao G, Zhang Y
Drug Design, Development and Therapy 2019, 13:435-445
Published Date: 22 January 2019
Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators
Al-Oudat BA, Alqudah MA, Audat SA, Al-Balas QA, El-Elimat T, Hassan MA, Frhat IN, Azaizeh MM
Drug Design, Development and Therapy 2019, 13:423-433
Published Date: 22 January 2019
Statin use and prognosis of lung cancer: a systematic review and meta-analysis of observational studies and randomized controlled trials
Xia DK, Hu ZG, Tian YF, Zeng FJ
Drug Design, Development and Therapy 2019, 13:405-422
Published Date: 23 January 2019
A real-life experience of sorafenib treatment for patients with advanced hepatocellular carcinoma: a retrospective analysis at Cathay General Hospital, 2007–2015
Huang CC, Chen HY, Chang RH, Liao PA, Lien HH, Hung CS, Yang SS, Hu JT
Drug Design, Development and Therapy 2019, 13:397-404
Published Date: 22 January 2019
Melatonin receptor stimulation by agomelatine prevents Aβ-induced tau phosphorylation and oxidative damage in PC12 cells
Yao K, Zhao Y, Zu H
Drug Design, Development and Therapy 2019, 13:387-396
Published Date: 21 January 2019
Letter regarding the article, “A randomized, double-blind clinical trial of canrenone vs hydrochlorothiazide in addition to angiotensin II receptor blockers in hypertensive type 2 diabetic patients”
Zhao LY, Luo YJ, Zhu J
Drug Design, Development and Therapy 2019, 13:385-386
Published Date: 21 January 2019
Development of dual delivery antituberculotic system containing rifapentine microspheres and adipose stem cells seeded in hydroxyapatite/tricalcium phosphate
Liang Q, Song X, She S, Wang Z, Wang C, Jiang D
Drug Design, Development and Therapy 2019, 13:373-384
Published Date: 18 January 2019
Different effects of oxycodone and remifentanil in patients undergoing ultrasound-guided percutaneous radiofrequency ablation of hepatic cancer: a randomized trial
Wu J, Lu Y, Cao X
Drug Design, Development and Therapy 2019, 13:365-372
Published Date: 18 January 2019
Screening of novel HSP-inducing compounds to conserve cardiomyocyte function in experimental atrial fibrillation
van Marion DMS, Hu X, Zhang D, Hoogstra-Berends F, Seerden JPG, Loen L, Heeres A, Steen H, Henning RH, Brundel BJJM
Drug Design, Development and Therapy 2019, 13:345-364
Published Date: 18 January 2019
Recent advances in the treatment of pathogenic infections using antibiotics and nano-drug delivery vehicles
Giau VV, An SSA, Hulme J
Drug Design, Development and Therapy 2019, 13:327-343
Published Date: 18 January 2019
YB-1 modulates the drug resistance of glioma cells by activation of MDM2/p53 pathway
Tong H, Zhao K, Zhang J, Zhu J, Xiao J
Drug Design, Development and Therapy 2019, 13:317-326
Published Date: 14 January 2019
A brief report of toxicity end points of HER2 vaccines for the treatment of patients with HER2+ breast cancer
Costa R, Zaman S, Sharpe S, Helenowski I, Shaw C, Han H, Soliman H, Czerniecki B
Drug Design, Development and Therapy 2019, 13:309-316
Published Date: 14 January 2019
Intravitreal corticosteroid implant vs intravitreal ranibizumab for the treatment of macular edema: a meta-analysis of randomized controlled trials
Wei Q, Chen R, Lou Q, Yu J
Drug Design, Development and Therapy 2019, 13:301-307
Published Date: 11 January 2019
Hyperprogression after anti-programmed cell death ligand-1 therapy in a patient with recurrent metastatic urothelial bladder carcinoma following first-line cisplatin-based chemotherapy: a case report
Mao S, Zhang J, Guo Y, Zhang Z, Wu Y, Zhang W, Wang L, Jiang Geng, Yan Y, Yao X
Drug Design, Development and Therapy 2019, 13:291-300
Published Date: 11 January 2019
Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways
Ren H, Li Y, Chen Y, Wang L
Drug Design, Development and Therapy 2019, 13:285-290
Published Date: 11 January 2019
Antistaphylococcal evaluation of indole–naphthalene hybrid analogs
Ashraf K, Yasrebi K, Adeniyi ET, Hertlein T, Ohlsen K, Lalk M, Erdmann F, Hilgeroth A
Drug Design, Development and Therapy 2019, 13:275-283
Published Date: 10 January 2019
Effect of progesterone administration on the prognosis of patients with severe traumatic brain injury: a meta-analysis of randomized clinical trials
Pan ZY, Zhao YH, Huang WH, Xiao ZZ, Li ZQ
Drug Design, Development and Therapy 2019, 13:265-273
Published Date: 11 January 2019
Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles
Huang X, Zhang S, Ma Y, Yang H, He C, Tian R, Mei H, Liu L, Zhang B
Drug Design, Development and Therapy 2019, 13:255-264
Published Date: 31 December 2018
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway
Wang Y, Shao YL, Gao YQ, Wan GR, Wan D, Zhu HF, Qiu Y, Ye XY
Drug Design, Development and Therapy 2019, 13:243-253
Published Date: 31 December 2018
A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model
Yang Y, Kim W, Kim D, Jeong S, Yoo JW, Jung Y
Drug Design, Development and Therapy 2019, 13:231-242
Published Date: 28 December 2018
Comparative effectiveness and safety of traditional Chinese medicine supporting Qi and enriching blood for cancer related anemia in patients not receiving chemoradiotherapy: a meta-analysis and systematic review
Dang Z, Liu X, Wang X, Li M, Jiang Y, Wang X, Yang Z
Drug Design, Development and Therapy 2019, 13:221-230
Published Date: 28 December 2018
Formulation and clinical investigation of optimized vinpocetine lyoplant-tabs: new strategy in development of buccal solid dosage form
Ahmed TA
Drug Design, Development and Therapy 2019, 13:205-220
Published Date: 28 December 2018
Efficacy and safety of sodium cantharidinate and vitamin B6 injection for the treatment of digestive system neoplasms: a meta-analysis of randomized controlled trials
Liu MR, Xu CH, Sun YY
Drug Design, Development and Therapy 2019, 13:183-203
Published Date: 28 December 2018
Xyloketal derivative C53N protects against mild traumatic brain injury in mice
Liang F, Su F, Wang X, Long S, Zheng Y, He X, Pang J, Pei Z
Drug Design, Development and Therapy 2019, 13:173-182
Published Date: 27 December 2018
Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis
Shi J, Li Y, Xing C, Peng P, Shi H, Ding H, Zheng P, Ning G, Feng S
Drug Design, Development and Therapy 2019, 13:161-172
Published Date: 27 December 2018
Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats
Wang X, Shan Y, Tang Z, Gao L, Liu H
Drug Design, Development and Therapy 2019, 13:153-160
Published Date: 21 December 2018
Fenofibrate modified-release pellets with lag phase and high oral bioavailability
Li F, Zheng X, Bao YC, Chen T, Zeng J, Xu XL, Yan C, Feng LL
Drug Design, Development and Therapy 2019, 13:141-151
Published Date: 24 December 2018
Pharmacokinetic interactions and tolerability of berberine chloride with simvastatin and fenofibrate: an open-label, randomized, parallel study in healthy Chinese subjects
Li G, Zhao M, Qiu F, Sun Y, Zhao L
Drug Design, Development and Therapy 2019, 13:129-139
Published Date: 20 December 2018
Tetrandrine suppresses cervical cancer growth by inducing apoptosis in vitro and in vivo
Zhang H, Xie B, Zhang Z, Sheng X, Zhang S
Drug Design, Development and Therapy 2019, 13:119-127
Published Date: 20 December 2018
Potential therapeutic effects of Cordyceps cicadae and Paecilomyces cicadae on adenine-induced chronic renal failure in rats and their phytochemical analysis
Li L, Zhang T, Li C, Xie L, Li N, Hou T, Wang Y, Wang B
Drug Design, Development and Therapy 2019, 13:103-117
Published Date: 19 December 2018
Efficacy of neoadjuvant platinum-based chemotherapy during the second and third trimester of pregnancy in women with cervical cancer: an updated systematic review and meta-analysis
Song Y, Liu Y, Lin M, Sheng B, Zhu X
Drug Design, Development and Therapy 2019, 13:79-102
Published Date: 19 December 2018
Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats
Zhang Q, Nie J, Chen S, Li Q
Drug Design, Development and Therapy 2019, 13:71-77
Published Date: 19 December 2018
Tocilizumab in the treatment of rheumatoid arthritis: an evidence-based review and patient selection
Biggioggero M, Crotti C, Becciolini A, Favalli EG
Drug Design, Development and Therapy 2019, 13:57-70
Published Date: 19 December 2018
Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head
Fang S, Li Y, Chen P
Drug Design, Development and Therapy 2019, 13:45-55
Published Date: 18 December 2018
Ocular side effects of levitra® (vardenafil) – results of a double-blind crossover study in healthy male subjects
Roessler G, Vobig M, Walter P, Mazinani BAE
Drug Design, Development and Therapy 2019, 13:37-43
Published Date: 18 December 2018
Multimetal organic frameworks as drug carriers: aceclofenac as a drug candidate
Al Haydar M, Abid HR, Sunderland B, Wang S
Drug Design, Development and Therapy 2019, 13:23-35
Published Date: 18 December 2018
Cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study
Samdanci ET, Huz M, Ozhan O, Tanbek K, Pamukcu E, Akatli AN, Parlakpinar H
Drug Design, Development and Therapy 2019, 13:13-21
Published Date: 20 December 2018
Combination of rifaximin and lactulose improves clinical efficacy and mortality in patients with hepatic encephalopathy
Wang Z, Chu P, Wang W
Drug Design, Development and Therapy 2019, 13:1-11
Published Date: 17 December 2018