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Critical appraisal of Timothy grass pollen extract GRAZAX® in the management of allergic rhinitis

Authors Scaparrotta A, Attanasi M, Petrosino M, Di Filippo P, Di Pillo S, Chiarelli F

Received 13 June 2015

Accepted for publication 14 September 2015

Published 3 November 2015 Volume 2015:9 Pages 5897—5909

DOI https://doi.org/10.2147/DDDT.S70432

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Wei Duan


Alessandra Scaparrotta, Marina Attanasi, Marianna I Petrosino, Paola Di Filippo, Sabrina Di Pillo, Francesco Chiarelli

Department of Pediatrics, University of Chieti, Chieti, Italy

Abstract: Allergic rhinitis is one of the most common diseases of adult and pediatric age, associated with grass pollen (GP) allergy in >50% cases, with a consistent impact on quality of life of affected patients. A grass allergen tablet, containing standardized extract derived from Timothy grass (Phleum pratense) pollen and ~15 µg major allergen P. pratense (rPhl p 5), may be the future of allergen-specific immunotherapy (IT) for GP allergy. The aim of this review was to critically evaluate the role of Timothy GP extract IT for the management of allergic rhinitis. For this purpose, we have tried to analyze potential mechanisms of action at the basis of Timothy GP extract, we have reviewed efficacy studies to establish potential benefits and clinical response, and we have also evaluated safety and tolerability profiles and patient focus perspective, such as quality of life, satisfaction and acceptability, and compliance to this IT.

Keywords: Timothy grass pollen extract, allergic rhinitis, Grazax, efficacy, safety, compliance

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