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Critical appraisal of bevacizumab in the treatment of ovarian cancer

Authors Yoshida H, Yabuno A, Fujiwara K

Received 21 February 2015

Accepted for publication 7 April 2015

Published 28 April 2015 Volume 2015:9 Pages 2351—2358

DOI https://doi.org/10.2147/DDDT.S83275

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5

Editor who approved publication: Professor Shu-Feng Zhou


Hiroyuki Yoshida, Akira Yabuno, Keiichi Fujiwara

Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan

Abstract: Bevacizumab is the first molecular-targeted agent to be used for the treatment of ovarian cancer. Bevacizumab is a humanized monoclonal antibody targeting vascular endothelial growth factor. Two randomized Phase III trials evaluated the combination of bevacizumab plus standard cytotoxic chemotherapy for first-line treatment of advanced ovarian cancer. Additional Phase III trials evaluated bevacizumab combined with cytotoxic chemotherapy in platinum-sensitive and platinum-resistant recurrent ovarian cancer. All these trials reported a statistically significant improvement in progression-free survival but not in overall survival. Furthermore, bevacizumab effectively improved the quality of life with regard to abdominal symptoms in recurrent ovarian cancer patients. Bevacizumab is associated with adverse events not commonly observed with cytotoxic agents used to treat gynecological cancers, such as hypertension, bleeding, thromboembolism, proteinuria, delayed wound healing, and gastrointestinal events. However, most of these events can be adequately managed by gynecologists. The clinical trial results with bevacizumab have supported its recent approval in Europe and the United States as a treatment for ovarian cancer. This review presents the latest evidence for bevacizumab therapy of ovarian cancer and describes selection of patients for personalized treatment.

Keywords: anti-angiogenesis, chemotherapy, biomarkers

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