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Comparative efficacy of pitavastatin and simvastatin in patients with hypercholesterolemia: a meta-analysis of randomized controlled clinical trials

Authors Ma N, Cui L

Received 9 May 2014

Accepted for publication 18 July 2014

Published 31 March 2015 Volume 2015:9 Pages 1859—1864

DOI https://doi.org/10.2147/DDDT.S67448

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3


Ning Ma,1,2 Lianqun Cui1

1Department of Cardiology, Shandong Provincial Hospital, Shandong University, 2Department of Cardiology, Heze Municipal Hospital, Heze, Shandong, People's Republic of China


Background: Simvastatin is a statin used to lower low-density lipoprotein cholesterol, but has limitations in patients on complicated regimens due to concerns about drug-drug interactions. Pitavastatin is a newly developed statin with limited drug-drug interactions. We conducted a meta-analysis to compare the clinical efficacy of simvastatin and pitavastatin in the control of hypercholesterolemia.
Methods: Randomized clinical trials comparing the efficacy of pitavastatin and simvastatin were identified by searching PubMed (2000–2014) and EMBASE (2000–2014). The primary outcome subjected to meta-analysis was percent change in low-density lipoprotein cholesterol compared with baseline.
Results: Four clinical trials were selected for meta-analysis. A total of 908 patients treated with pitavastatin (2 or 4 mg/day) and 381 patients treated with simvastatin (20 or 40 mg/day) were included in the final statistical analysis. No statistically significant difference was identified between treatment with pitavastatin 4 mg/day and treatment with simvastatin 40 mg/day for 12 weeks (mean difference -0.66; 95% confidence interval -2.92, 1.61; P=0.57). Similarly, no statistically significant difference was observed between pitavastatin 2 mg/day and simvastatin 20 mg/day for 4 weeks (mean difference -2.19; 95% confidence interval -0.11, 4.49; P=0.06). Treatment with pitavastatin was noninferior to simvastatin in all of the secondary outcomes and the safety profile was similar between the two statins.
Conclusion: Pitavastatin is noninferior to simvastatin in lowering low-density lipoprotein cholesterol.

Keywords: pitavastatin, simvastatin, hypercholesterolemia, meta-analysis

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