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Canakinumab as rescue therapy in familial Mediterranean fever refractory to conventional treatment

Authors Alpa M, Roccatello D

Received 10 June 2014

Accepted for publication 11 July 2014

Published 17 April 2015 Volume 2015:9 Pages 1983—1987

DOI https://doi.org/10.2147/DDDT.S69117

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3


Mirella Alpa, Dario Roccatello

Centro di Ricerche di Immunopatologia e Documentazione su Malattie Rare (CMID), Struttura Complessa Direzione Universitaria di Immunologia Clinica, Università di Torino e Ospedale G Bosco, Torino, Italy

Abstract: Familial Mediterranean fever is an autosomal recessive autoinflammatory disorder mainly affecting Mediterranean populations, which is associated with mutations of the MEFV gene that encodes pyrin. Functional studies suggest that pyrin is implicated in the maturation and secretion of interleukin-1 (IL-1). The IL-1 receptor antagonist or anti-IL-1 monoclonal antibody may therefore represent a rational approach for the treatment of the rare patients who are refractory to conventional therapy. We report the case of a young female affected by familial Mediterranean fever who proved to be resistant to colchicine and was successfully treated with canakinumab.

Keyword: interleukin-1, colchicine, familial Mediterranean fever, anti-IL-1 treatment, biologic agents

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