Other papers submitted by: Dr Ozair Alam

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Paper published by Dr Ozair Alam:

Original Research

Noteworthy comment: The manuscript designed and synthesized a series of hybrid pyrazole analogues. The in vitro and in vivo assays including TNF-α assay, Nitric Oxide Assay, Cyclooxygenase assay, MTT assay, identified two compounds which have anti-inflammatory effects against COX-I/II and TNF-α. Further docking studies showed that the two compounds can dock into the active site of COX-II and have similar docking scores as celecoxib. This is good work on development of anti-inflammatory drugs.

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Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues

Alam MJ, Alam O, Khan SA, Naim MJ, Islamuddin M, Deora GS

Drug Design, Development and Therapy 2016, 10:3529-3543

Published Date: 31 October 2016