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Applications of calixarenes in cancer chemotherapy: facts and perspectives
Authors Yousaf A, Abd Hamid S, M Bunnori N, Ishola AA
Received 20 February 2015
Accepted for publication 2 April 2015
Published 2 June 2015 Volume 2015:9 Pages 2831—2838
DOI https://doi.org/10.2147/DDDT.S83213
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Shu-Feng Zhou
Ali Yousaf,1 Shafida Abd Hamid,1 Noraslinda M Bunnori,1 AA Ishola2
1Kulliyyah of Science, 2Kulliyyah of Medicine, International Islamic University Malaysia, Bandar Indera Mahkota, Malaysia
Abstract: Research on the therapeutic applications of calixarene derivatives is an emerging area of interest. The anticancer activity of various functionalized calixarenes has been reported by several research groups. Due to their superior geometric shape, calixarenes can accommodate drug molecules by forming inclusion complexes. Controlled release of anticancer drugs by calixarenes might help in targeted chemotherapy. This review summarizes the anticancer potential of the calixarenes and their drug loading properties. The potential use of calixarenes in chemoradiotherapy is also highlighted in brief.
Keywords: cancer, chemotherapy, calixarenes
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