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Applications of calixarenes in cancer chemotherapy: facts and perspectives

Authors Yousaf A, Abd Hamid S, M Bunnori N, Ishola AA

Received 20 February 2015

Accepted for publication 2 April 2015

Published 2 June 2015 Volume 2015:9 Pages 2831—2838

DOI https://doi.org/10.2147/DDDT.S83213

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Professor Shu-Feng Zhou


Ali Yousaf,1 Shafida Abd Hamid,1 Noraslinda M Bunnori,1 AA Ishola2

1Kulliyyah of Science, 2Kulliyyah of Medicine, International Islamic University Malaysia, Bandar Indera Mahkota, Malaysia

Abstract: Research on the therapeutic applications of calixarene derivatives is an emerging area of interest. The anticancer activity of various functionalized calixarenes has been reported by several research groups. Due to their superior geometric shape, calixarenes can accommodate drug molecules by forming inclusion complexes. Controlled release of anticancer drugs by calixarenes might help in targeted chemotherapy. This review summarizes the anticancer potential of the calixarenes and their drug loading properties. The potential use of calixarenes in chemoradiotherapy is also highlighted in brief.

Keywords: cancer, chemotherapy, calixarenes

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