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Frailty in Older Patients with Acute Coronary Syndrome in Vietnam

Authors Nguyen TV, Le D, Tran KD, Bui KX, Nguyen TN

Received 14 October 2019

Accepted for publication 27 November 2019

Published 17 December 2019 Volume 2019:14 Pages 2213—2222

DOI https://doi.org/10.2147/CIA.S234597

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Tan Van Nguyen,1,2 Duong Le,1,2 Khuong Dang Tran,1 Khai Xuan Bui,1 Tu Ngoc Nguyen3

1Department of Geriatrics & Gerontology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; 2Department of Interventional Cardiology, Thong Nhat Hospital, Ho Chi Minh City, Vietnam; 3Westmead Applied Research Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia

Correspondence: Tan Van Nguyen
Department of Geriatrics & Gerontology, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam
Tel +84 903 739 273
Email nguyenvtan10@ump.edu.vn

Background: There has been limited evidence about frailty in older patients with acute coronary syndrome (ACS) in Vietnam.
Aim: (1) To investigate the prevalence of frailty in older patients hospitalised with ACS and its associated factors; (2) To investigate the impact of frailty on percutaneous coronary intervention (PCI) and adverse outcomes in this population.
Methods: Patients aged ≥60 with ACS admitted to two teaching hospitals in Vietnam were recruited from 9/2017 to 4/2018. Frailty was defined by the Reported Edmonton Frail Scale. Multivariate logistic regression was applied to investigate the associated factors of frailty and the impact of frailty on PCI and adverse outcomes.
Results: There were 324 participants, mean age 73.5±8.3, 39.2% female. The prevalence of frailty was 48.1%. Advanced age, female gender, history of hypertension, heart failure, stroke and chronic kidney disease were significantly associated with a frailty status. Overall, 50.3% of the participants received PCI (58.3% in the non-frail vs 41.7% in the frail, p=0.003). However, frailty did not have an independent impact on PCI (adjusted OR 0.66, 95% CI 0.41–1.08). Frailty was significantly associated with increased risk of having arrhythmia during hospitalisation (adjusted OR 2.24, 95% CI 1.32–3.80), hospital-acquired pneumonia (adjusted OR 2.27, 95% CI 1.24–4.17), in-hospital mortality (adjusted OR 3.02, 95% CI 1.35–6.75), 30-day mortality (adjusted OR 3.28, 95% CI 1.59–6.76), and 30-day readmission (adjusted OR 2.53, 95% CI 1.38–4.63).
Conclusion: In this study, frailty was present in nearly half of older patients with ACS and was associated with increased adverse outcomes. These findings suggest that frailty screening should be performed in older patients with ACS in Vietnam.

Keywords: frailty, acute coronary syndrome, elderly, older patients, adverse outcomes, Vietnam

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