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Fospropofol disodium injection for the sedation of patients undergoing colonoscopy

Authors Levitzky BE, Vargo JJ

Published 8 August 2008 Volume 2008:4(4) Pages 733—738


Review by Single-blind

Peer reviewer comments 2

Benjamin E Levitzky1, John J Vargo2

1Department of Gastroenterology and Hepatology, 2Section of Therapeutic and Hepatobiliary Endoscopy, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA

Abstract: Sedation plays a central role in making colonoscopy tolerable for patients and feasible for the endoscopist to perform. The array of agents used for endoscopic sedation continues to evolve. Fospropofol (FP), a prodrug of propofol with a slower pharmacokinetic profi le, is currently under evaluation for use during endoscopic procedures. Preliminary data suggests that FP dosed at 6.5 mg/kg is well tolerated by most patients with perineal paresthesias being the most commonly experienced adverse effect. This article will examine the current literature on the use of FP for the sedation of patients undergoing colonoscopy, highlighting the pharmacokinetics, pharmacodynamics, risks, and common adverse events associated with the novel sedative/hypnotic.

Keywords: fospropofol, Aquavan, propofol, sedation, colonoscopy

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