Back to Journals » International Journal of Nanomedicine » Volume 8 » Issue 1

Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene- loaded nanostructured lipid carriers

Authors Shi F, Yang G, Ren J, Guo T, Du Y, Feng N

Received 11 April 2013

Accepted for publication 24 May 2013

Published 22 July 2013 Volume 2013:8(1) Pages 2533—2541

DOI https://doi.org/10.2147/IJN.S46578

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Feng Shi,1 Gang Yang,1 Juan Ren,2 Teng Guo,1 Yan Du,1 Nianping Feng1

1Department of Pharmaceutics, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China; 2Department of Traditional Chinese Medicine, Changhai Hospital, Shanghai, People's Republic of China

Abstract: In the present study, nanostructured lipid carriers (NLCs) were prepared and optimized for the intravenous delivery of β-Elemene (β-E). Aqueous dispersions of NLCs were successfully prepared by high-pressure homogenization method using glycerol monostearate as the solid lipid and a mixture of Maisine 35-1 and Labrafil M1944 CS as the liquid lipid. The results revealed that the morphology of the NLCs was spheroidal. The particle size, zeta potential, and entrapment efficiency (EE) for the optimized formulation were observed as 138.9 nm, –20.2 mV, and 82.11%, respectively. X-ray diffraction analysis revealed the formation of less ordered structures in the inner core of the NLC particles. Moreover, the β-E-loaded NLCs were also less irritating and less toxic compared to Elemene injection. In addition, β-E-NLCs showed a significantly higher bioavailability and anti-tumor efficacy than Elemene injection. Taken together, our data indicate that the β-E-NLCs described in this study are well-suited for the intravenous delivery of β-E.

Keywords: nanostructured lipid carriers, high-pressure homogenization, β-Elemene, venous irritation, anti-tumor efficacy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

Development of high drug-loading nanomicelles targeting steroids to the brain

Zheng S, Xie Y, Li Y, Li L, Tian N, Zhu W, Yan G, Wu C, Hu H

International Journal of Nanomedicine 2014, 9:55-66

Published Date: 18 December 2013

Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles

Rangger C, Helbok A, Sosabowski J, Kremser C, Koehler G, Prassl R, Andreae F, Virgolini IJ, von Guggenberg E, Decristoforo C

International Journal of Nanomedicine 2013, 8:4659-4671

Published Date: 5 December 2013

Preparation, characterization, and in vivo pharmacokinetics of nanostructured lipid carriers loaded with oleanolic acid and gentiopicrin

Zhang KC, Lv SW, Li XY, Feng YF, Li X, Liu L, Li S, Li YJ

International Journal of Nanomedicine 2013, 8:3227-3239

Published Date: 22 August 2013

Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Mushahary D, Sravanthi R, Li Y, Kumar MJ, Harishankar N, Hodgson PD, Wen C, Pande G

International Journal of Nanomedicine 2013, 8:2887-2902

Published Date: 9 August 2013

Paclitaxel-loaded poly(glycolide-co-ε-caprolactone)-b-D-α-tocopheryl polyethylene glycol 2000 succinate nanoparticles for lung cancer therapy

Zhao TJ, Chen HZ, Dong YC, Zhang JJ, Huang HD, Zhu J, Zhang W

International Journal of Nanomedicine 2013, 8:1947-1957

Published Date: 16 May 2013

Biofunctionalization of a titanium surface with a nano-sawtooth structure regulates the behavior of rat bone marrow mesenchymal stem cells

Zhang WJ, Li ZH, Liu Y, Ye DX, Li JH, Xu LY, Wei B, Zhang XL, Liu XY, Jiang XQ

International Journal of Nanomedicine 2012, 7:4459-4472

Published Date: 13 August 2012

Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles

Vannucci L, Falvo E, Fornara M, Di Micco P, Benada O, Krizan J, Svoboda J, Hulikova-Capkova K, Morea V, Boffi A, Ceci P

International Journal of Nanomedicine 2012, 7:1489-1509

Published Date: 16 March 2012

Size-dependent in vivo toxicity of PEG-coated gold nanoparticles

Zhang XD, Wu D, Shen X, Liu PX, Yang N, Zhao B, Zhang H, Sun YM, Zhang LA, Fan FY

International Journal of Nanomedicine 2011, 6:2071-2081

Published Date: 20 September 2011