Back to Journals » Therapeutics and Clinical Risk Management » Volume 4 » Issue 2

Fluticasone furoate nasal spray in the treatment of allergic rhinitis

Authors Giavina-Bianchi P, Agondi R, Stelmach R, Cukier A, Kalil J

Published 11 April 2008 Volume 2008:4(2) Pages 465—472


Pedro Giavina-Bianchi1, Rosana Agondi1, Rafael Stelmach2, Alberto Cukier2, Jorge Kalil1

1Division of Clinical Immunology and Allergy, University of São Paulo, São Paulo, Brazil; 2Pulmonary Division, University of São Paulo, São Paulo, Brazil

Abstract: Allergic rhinitis (AR) is a prevalent disease with great morbidity and significant societal and economic burden. Intranasal corticosteroids are recommended as first-line therapy for patients with moderate-to-severe disease, especially when nasal congestion is a major component of symptoms. To compare the efficacy and safety profile of different available intranasal corticosteroids for the treatment of AR, it is important to understand their different structures and pharmacokinetic and pharmacodynamic properties. Knowledge of these drugs has increased tremendously over the last decade. Studies have elucidated mechanisms of action, pharmacologic properties, and the clinical impact of these drugs in allergic respiratory diseases. Although the existing intranasal corticosteroids are already highly efficient, the introduction of further improved formulations with a better efficacy/safety profile is always desired. Fluticasone furoate nasal spray is a new topical corticosteroid, with enhanced-affinity and a unique side-actuated delivery device. As it has high topical potency and low potential for systemic effects, it is a good candidate for rhinitis treatment.

Keywords: fluticasone furoate, corticosteroids, rhinitis, efficacy, safety, ARIA

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]