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Fluorescent gold nanoclusters for efficient cancer cell targeting
Authors Purohit R, Singh S
Received 18 October 2016
Accepted for publication 31 October 2016
Published 15 March 2018 Volume 2018:13(T-NANO 2014 Abstracts) Pages 15—17
DOI https://doi.org/10.2147/IJN.S125003
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Lei Yang
Rahul Purohit, Sanjay Singh
Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India
Abstract: Well-known surface properties of gold nanoparticles (AuNPs) offer easy surface modification with desired biomolecule, thus enabling them to be used for targeting and imaging of cancer cells/tissues. However, targeting and imaging capability come through after synthesis coating of AuNPs’ surface with targeting or imaging molecules. Attempts have been made to conjugate both imaging and targeting molecules over the AuNPs, but have seen limited success. Hence, exploiting the fluorescence properties of gold nanoclusters (AuNCs), we have synthesized glucose-coated AuNCs for exhibiting both the imaging and targeting properties. These clusters have shown rapid and selective uptake in cancerous (A549) cells when compared with bovine serum albumin-coated AuNCs.
Keywords: gold nanoclusters, fluorescent AuNCs, cancer cell imaging and targeting
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