Back to Journals » International Journal of Nanomedicine » Volume 13 » T-NANO 2014 Abstracts

Fluorescent gold nanoclusters for efficient cancer cell targeting

Authors Purohit R, Singh S

Received 18 October 2016

Accepted for publication 31 October 2016

Published 15 March 2018 Volume 2018:13(T-NANO 2014 Abstracts) Pages 15—17

DOI https://doi.org/10.2147/IJN.S125003

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Lei Yang


Rahul Purohit, Sanjay Singh

Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India


Abstract: Well-known surface properties of gold nanoparticles (AuNPs) offer easy surface modification with desired biomolecule, thus enabling them to be used for targeting and imaging of cancer cells/tissues. However, targeting and imaging capability come through after synthesis coating of AuNPs’ surface with targeting or imaging molecules. Attempts have been made to conjugate both imaging and targeting molecules over the AuNPs, but have seen limited success. Hence, exploiting the fluorescence properties of gold nanoclusters (AuNCs), we have synthesized glucose-coated AuNCs for exhibiting both the imaging and targeting properties. These clusters have shown rapid and selective uptake in cancerous (A549) cells when compared with bovine serum albumin-coated AuNCs.

Keywords: gold nanoclusters, fluorescent AuNCs, cancer cell imaging and targeting

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]