Drug Design, Development and Therapy

Drug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19New articles released by Dove Press for Drug Design, Development and Therapyen-us2026, Dove Pressangela@dovepress.com (Angela Jones)Dove Press Drug Design, Development and TherapyDrug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19https://www.dovepress.com/assets/img/addon/rss-banner.jpg140140Short-Term Glycemic Outcomes Associated with Imeglimin Use Among Patients with Type 2 Diabetes Mellitus: A Prospective Observational Studyhttps://www.dovepress.com/short-term-glycemic-outcomes-associated-with-imeglimin-use-among-patie-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapySat, 18 Jul 2026 22:20:00 +1200https://doi.org/10.2147/DDDT.S601458The Effect of Food on the Pharmacokinetics and Gastrointestinal Tolerability of Bersiporocin, a Novel Oral Prolyl-tRNA-Synthetase Inhibitorhttps://www.dovepress.com/the-effect-of-food-on-the-pharmacokinetics-and-gastrointestinal-tolera-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 17 Jul 2026 04:30:00 +1200https://doi.org/10.2147/DDDT.S609676Comparison of the ED90 of Esketamine for Suppressing Laryngeal Mask Airway Insertion Responses During Propofol Induction with or without Intravenous Lidocaine Pretreatment: A Randomized Double-Blind Dose-Finding Trialhttps://www.dovepress.com/comparison-of-the-ed90-of-esketamine-for-suppressing-laryngeal-mask-ai-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 16 Jul 2026 21:55:00 +1200https://doi.org/10.2147/DDDT.S609448Safety of Short-T erm Low-Dose Olanzapine in Patients with Cancer and Diabetes Receiving Cisplatin-Based Chemotherapy: A Retrospective TriNetX Cohort Studyhttps://www.dovepress.com/safety-of-short-term-low-dose-olanzapine-in-patients-with-cancer-and-d-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 16 Jul 2026 19:05:00 +1200https://doi.org/10.2147/DDDT.S615968The Effect of Esketamine on Peripheral Vascular Resistance in Elderly Patients During Anesthesia Induction: A Single-Center, Double-Blind, Prospective, Randomized Controlled Studyhttps://www.dovepress.com/the-effect-of-esketamine-on-peripheral-vascular-resistance-in-elderly--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 16 Jul 2026 19:00:00 +1200https://doi.org/10.2147/DDDT.S607757Bicaudal‑C1 in Cancer: Molecular Mechanisms and Therapeutic Strategies Integrating Chinese and Western Medicinehttps://www.dovepress.com/bicaudalc1-in-cancer-molecular-mechanisms-and-therapeutic-strategies-i-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 15 Jul 2026 17:25:00 +1200https://doi.org/10.2147/DDDT.S606851Obinutuzumab as a Rescue and Maintenance Strategy in Children with Difficult-to-Treat Nephrotic Syndrome After Rituximab-Based Treatment Failure or Intolerance: A Preliminary Single-Center Real-World Retrospective Studyhttps://www.dovepress.com/obinutuzumab-as-a-rescue-and-maintenance-strategy-in-children-with-dif-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 15 Jul 2026 04:30:00 +1200https://doi.org/10.2147/DDDT.S619807Early Detection and Temporal Progression of Hemidiaphragmatic Paralysis After Supraclavicular Brachial Plexus Block with 20 mL vs 30 mL Ropivacaine: A Randomized Controlled Trialhttps://www.dovepress.com/early-detection-and-temporal-progression-of-hemidiaphragmatic-paralysi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 15 Jul 2026 00:25:00 +1200https://doi.org/10.2147/DDDT.S598288Comparative Risk of Psoriatic Arthritis in Type 2 Diabetes: An Emulated Target Trial of SGLT2 Inhibitors vs. GLP-1 Receptor Agonistshttps://www.dovepress.com/comparative-risk-of-psoriatic-arthritis-in-type-2-diabetes-an-emulated-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 15 Jul 2026 00:10:00 +1200https://doi.org/10.2147/DDDT.S614222Methodological Concerns Regarding ED95 Estimation and Outcome Interpretation in the Remimazolam Dose-Finding Study for HIFU Ablation [Letter]https://www.dovepress.com/methodological-concerns-regarding-ed95-estimation-and-outcome-interpre-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 19:50:00 +1200https://doi.org/10.2147/DDDT.S637737Real-World Comparative Weight Loss of GLP-1 Receptor Agonists in the All of Us Research Program: A Retrospective Cohort Studyhttps://www.dovepress.com/real-world-comparative-weight-loss-of-glp-1-receptor-agonists-in-the-a-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 04:25:00 +1200https://doi.org/10.2147/DDDT.S604247Targeting Bruton’s Tyrosine Kinase (BTK) in Autoimmunity: Achievements, Opportunities and Challengeshttps://www.dovepress.com/targeting-brutons-tyrosine-kinase-btk-in-autoimmunity-achievements-opp-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 04:05:00 +1200https://doi.org/10.2147/DDDT.S568214Effect of Oliceridine on the Acute Postoperative Pain Management After Elective Cesarean Delivery: A Randomized Non-Inferiority Trialhttps://www.dovepress.com/effect-of-oliceridine-on-the-acute-postoperative-pain-management-after-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 03:05:00 +1200https://doi.org/10.2147/DDDT.S603352Tumor Assembloids as Three-Dimensional Platforms for Modeling Drug Delivery Barriers: Construction Strategies, Applications, and Translational Challengeshttps://www.dovepress.com/tumor-assembloids-as-three-dimensional-platforms-for-modeling-drug-del-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 02:00:00 +1200https://doi.org/10.2147/DDDT.S618870Oliceridine versus Sufentanil on Postoperative Nausea and Vomiting in Women Undergoing Gynecological Laparoscopic Surgery: A Randomized Double‑Blind Controlled Trialhttps://www.dovepress.com/oliceridine-versus-sufentanil-on-postoperative-nausea-and-vomiting-in--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 01:30:00 +1200https://doi.org/10.2147/DDDT.S621409Perioperative Butorphanol for the Prevention of Postoperative Pulmonary Complications After Thoracoscopic Lung Resection: A Randomized, Double-Blind, Placebo-Controlled Trialhttps://www.dovepress.com/perioperative-butorphanol-for-the-prevention-of-postoperative-pulmonar-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 01:25:00 +1200https://doi.org/10.2147/DDDT.S621698Dexamethasone Alone versus Combined with Droperidol for Preventing Postoperative Nausea and Vomiting in Gynecological Day Surgery Under Ciprofol-Alfentanil Anesthesia: A Randomized Double-Blind Controlled Trialhttps://www.dovepress.com/dexamethasone-alone-versus-combined-with-droperidol-for-preventing-pos-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 01:10:00 +1200https://doi.org/10.2147/DDDT.S625824The MEC90 of Ropivacaine for Ultrasound-Guided Pectoral Nerve Block Type II for Modified Radical Mastectomy: A Biased-Coin Up-and-Down Sequential Trialhttps://www.dovepress.com/the-mec90-of-ropivacaine-for-ultrasound-guided-pectoral-nerve-block-ty-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 13 Jul 2026 20:40:00 +1200https://doi.org/10.2147/DDDT.S6124210.06% Ropivacaine Combined with Double-Hole Dural Puncture Epidural Analgesia in Labor for Primiparous Women: A Prospective Randomized Controlled Trialhttps://www.dovepress.com/006-ropivacaine-combined-with-double-hole-dural-puncture-epidural-anal-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 14:10:00 +1200https://doi.org/10.2147/DDDT.S617452Cataract as an Endpoint-Dependent Confounder in Trials of Neuroprotective Therapies for Glaucoma [Letter]https://www.dovepress.com/cataract-as-an-endpoint-dependent-confounder-in-trials-of-neuroprotect-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 06:05:00 +1200https://doi.org/10.2147/DDDT.S635506Ultrasound-Guided Femoral Nerve Block with Esketamine Adjuvant for Postoperative Analgesia in Total Knee Arthroplasty–A Randomized, Double-Blind, Controlled Trialhttps://www.dovepress.com/ultrasound-guided-femoral-nerve-block-with-esketamine-adjuvant-for-pos-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 05:50:00 +1200https://doi.org/10.2147/DDDT.S609966Phase I Study Evaluating Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of Recombinant Human Serum Albumin (rHSA) in Healthy Adultshttps://www.dovepress.com/phase-i-study-evaluating-pharmacokinetics-pharmacodynamics-safety-and--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 05:45:00 +1200https://doi.org/10.2147/DDDT.S598274Effects of Remimazolam Dose and Bolus Injection Rate on Hiccups During Painless Colonoscopy: A Double-Blind Randomized Clinical Trial [Response to Letter]https://www.dovepress.com/effects-of-remimazolam-dose-and-bolus-injection-rate-on-hiccups-duri-3-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 03:50:00 +1200https://doi.org/10.2147/DDDT.S632112Induction of General Anesthesia with Fospropofol in Elderly Patients Undergoing Hip Surgery: An Efficacy and Safety Analysishttps://www.dovepress.com/induction-of-general-anesthesia-with-fospropofol-in-elderly-patients-u-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 01:50:00 +1200https://doi.org/10.2147/DDDT.S610270Semaglutide in Diabetic Periodontitis-Induced Osteoblast Ferroptosis: Pharmacological and Methodological Insights [Letter]https://www.dovepress.com/semaglutide-in-diabetic-periodontitis-induced-osteoblast-ferroptosis-p-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 01:35:00 +1200https://doi.org/10.2147/DDDT.S637327The Concentration Paradox: When Dose-Response Logic Collapses in a Photoaging Study [Letter]https://www.dovepress.com/the-concentration-paradox-when-dose-response-logic-collapses-in-a-phot-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 01:30:00 +1200https://doi.org/10.2147/DDDT.S637244Beyond Pleiotropy: A Call for Target Deconvolution and Chemopreventive Repositioning of Alkaloids in CRC [Letter]https://www.dovepress.com/beyond-pleiotropy-a-call-for-target-deconvolution-and-chemopreventive--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 01:20:00 +1200https://doi.org/10.2147/DDDT.S634308From Initiation to Recovery: A Longitudinal Analysis of Polymyxin B-Induced Kidney Injury in Clinical Practicehttps://www.dovepress.com/from-initiation-to-recovery-a-longitudinal-analysis-of-polymyxin-b-ind-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 09 Jul 2026 22:00:00 +1200https://doi.org/10.2147/DDDT.S613715Precision Endocrine-Based Combinations After CDK4/6 Inhibitor Progression in HR-Positive Metastatic Breast Cancerhttps://www.dovepress.com/precision-endocrine-based-combinations-after-cdk46-inhibitor-progressi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 09 Jul 2026 20:15:00 +1200https://doi.org/10.2147/DDDT.S611371Aceclofenac Nanocrystals with Enhanced in vitro, in vivo Performance: Formulation Optimization, Characterization, Analgesic and Acute Toxicity Studies [Expression of Concern]https://www.dovepress.com/eoc-aceclofenac-nanocrystals-with-enhanced-in-vitro-in-vivo-performanc-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 09 Jul 2026 15:30:00 +1200https://doi.org/10.2147/DDDT.S636789