Drug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19New articles released by Dove Press for Drug Design, Development and Therapyen-us2026, Dove Pressangela@dovepress.com (Angela Jones)Dove Press Drug Design, Development and TherapyDrug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19https://www.dovepress.com/assets/img/addon/rss-banner.jpg140140Real-World Outcomes of Aflibercept 2 mg Using a Treat-and-Extend Protocol for Neovascular Age-Related Macular Degeneration: A 24-Month Retrospective Study in a Chinese Populationhttps://www.dovepress.com/real-world-outcomes-of-aflibercept-2-mg-using-a-treat-and-extend-proto-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 05 Jun 2026 01:55:00 +1200https://doi.org/10.2147/DDDT.S601668Progress in the Treatment of Ulcerative Colitis by Targeting NLRP3 Inflammasomehttps://www.dovepress.com/progress-in-the-treatment-of-ulcerative-colitis-by-targeting-nlrp3-inf-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 04 Jun 2026 17:25:00 +1200https://doi.org/10.2147/DDDT.S611506Efficacy and Safety of Oteseconazole in Severe Vulvovaginal Candidiasis Categorized by Candida Species and Previous Genital Tract Infection: A Post Hoc Analysis of a Phase 3 Trialhttps://www.dovepress.com/efficacy-and-safety-of-oteseconazole-in-severe-vulvovaginal-candidiasi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 04 Jun 2026 17:15:00 +1200https://doi.org/10.2147/DDDT.S599356Determination of the ED90 of Remimazolam Bolus Dose for Preventing Emergence Delirium in Children with Sevoflurane Anesthesia: A Dose-Finding Study Using Biased-Coin Design Up-and-Down Sequential Methodhttps://www.dovepress.com/determination-of-the-ed90-of-remimazolam-bolus-dose-for-preventing-eme-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 04 Jun 2026 02:40:00 +1200https://doi.org/10.2147/DDDT.S608136An Efficient Pharmacogenomic Assay for Psychotropic Drugs by Multiplex Fluorescence Melting Curve Analysishttps://www.dovepress.com/an-efficient-pharmacogenomic-assay-for-psychotropic-drugs-by-multiplex-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 04 Jun 2026 01:00:00 +1200https://doi.org/10.2147/DDDT.S586665The Natural Compound Cornuside Protects Against Acute Liver Failure Induced by Lipopolysaccharide and D-Galactosaminehttps://www.dovepress.com/the-natural-compound-cornuside-protects-against-acute-liver-failure-in-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 18:20:00 +1200https://doi.org/10.2147/DDDT.S601517A Comprehensive Review of Hedyotis Diffusa Willd–Scutellaria Barbata D. Don Herb Pair in Anti- Hepatocellular Carcinoma Effects and Their Combinatorial Effects and Mechanismshttps://www.dovepress.com/a-comprehensive-review-of-hedyotis-diffusa-willdscutellaria-barbata-d--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 18:00:00 +1200https://doi.org/10.2147/DDDT.S603528Computational Discovery and Optimization of a Potent, Selective, and Drug-Like Scaffold for p38α Inhibitionhttps://www.dovepress.com/computational-discovery-and-optimization-of-a-potent-selective-and-dru-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 15:45:00 +1200https://doi.org/10.2147/DDDT.S585325Effect of Intraoperative Low-Dose Lidocaine Administration on the Consumption of Mivacurium During Gynecological Laparoscopic Surgery: A Prospective Clinical Studyhttps://www.dovepress.com/effect-of-intraoperative-low-dose-lidocaine-administration-on-the-cons-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 14:30:00 +1200https://doi.org/10.2147/DDDT.S600261Investigation of Esketamine Administration During Surgical Procedures for the Alleviation of Postoperative Anxiety and Depression in Adolescent Patients: A Randomized Controlled Trialhttps://www.dovepress.com/investigation-of-esketamine-administration-during-surgical-procedures--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 14:15:00 +1200https://doi.org/10.2147/DDDT.S587626Mechanisms of Traditional Chinese Medicine-Derived Alkaloids in Colorectal Cancer Therapy: Molecular Targets, Preclinical Evidence, and Translational Prospectshttps://www.dovepress.com/mechanisms-of-traditional-chinese-medicine-derived-alkaloids-in-colore-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 14:10:00 +1200https://doi.org/10.2147/DDDT.S564320Sacubitril/Valsartan Fails to Ameliorate Cisplatin-Induced Cognitive 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from Propofol Anesthesia in Patients Undergoing Laparoscopic Gynecological Surgery: A Randomized Controlled Trialhttps://www.dovepress.com/esketamine-accelerates-emergence-from-propofol-anesthesia-in-patients--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 03:35:00 +1200https://doi.org/10.2147/DDDT.S608572Astragaloside IV in Combination with Tanshinone IIA Ameliorates Cardiac Fibrosis After Myocardial Infarction by Inhibiting CTR1/ATOX1/LOX Axis-Mediated Collagen Cross-Linking in Myofibroblastshttps://www.dovepress.com/astragaloside-iv-in-combination-with-tanshinone-iia-ameliorates-cardia-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 03 Jun 2026 01:50:00 +1200https://doi.org/10.2147/DDDT.S588634DIF: Concepts, Measurement, and Impact in Patient-Focused Drug Development and Regulatory 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TherapyThu, 28 May 2026 20:15:00 +1200https://doi.org/10.2147/DDDT.S606156Oxycodone versus Sufentanil for Postoperative Analgesia and Early Recovery After Radical Gastrectomy: A Propensity Score-Matched Studyhttps://www.dovepress.com/oxycodone-versus-sufentanil-for-postoperative-analgesia-and-early-reco-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 28 May 2026 00:25:00 +1200https://doi.org/10.2147/DDDT.S606394Next-Generation Pharmacotherapy for Depressive Disorders: From Novel Compounds to Optimized Use of Available Drugshttps://www.dovepress.com/next-generation-pharmacotherapy-for-depressive-disorders-from-novel-co-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 27 May 2026 19:55:00 +1200https://doi.org/10.2147/DDDT.S609327Roles of Goserelin in Gynecological Disordershttps://www.dovepress.com/roles-of-goserelin-in-gynecological-disorders-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 27 May 2026 18:20:00 +1200https://doi.org/10.2147/DDDT.S595029Calcium Signaling Dysregulation as a Convergent Mechanism in Anesthetic-Induced Developmental Neurotoxicityhttps://www.dovepress.com/calcium-signaling-dysregulation-as-a-convergent-mechanism-in-anestheti-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 27 May 2026 04:40:00 +1200https://doi.org/10.2147/DDDT.S599516No Significant Difference Is Not Equivalence: Statistical Considerations on Phenylephrine Requirement in Left-Tilt versus Supine Cesarean Delivery [Response to Letter]https://www.dovepress.com/no-significant-difference-is-not-equivalence-statistical-considerati-2-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 27 May 2026 04:30:00 +1200https://doi.org/10.2147/DDDT.S624312Determining the Optimal Volume of Ropivacaine Combined with Dexmedetomidine for Programmed Intermittent Epidural Bolus in Labor Analgesia: A Randomized Dose-Response 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