Drug Design, Development and Therapy

Drug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19New articles released by Dove Press for Drug Design, Development and Therapyen-us2026, Dove Pressangela@dovepress.com (Angela Jones)Dove Press Drug Design, Development and TherapyDrug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19https://www.dovepress.com/assets/img/addon/rss-banner.jpg140140Simultaneous Quantification of Mycophenolic Acid and Its Glucuronide Metabolite in PBMCs from Kidney Transplant Recipients by LC-MS/MShttps://www.dovepress.com/simultaneous-quantification-of-mycophenolic-acid-and-its-glucuronide-m-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 23 Jul 2026 20:05:00 +1200https://doi.org/10.2147/DDDT.S622839Ciprofol versus Propofol Combined with Alfentanil for Respiratory Adverse Events in Overweight Patients Undergoing Painless Gastroscopy: A Randomized Controlled Trialhttps://www.dovepress.com/ciprofol-versus-propofol-combined-with-alfentanil-for-respiratory-adve-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 23 Jul 2026 13:25:00 +1200https://doi.org/10.2147/DDDT.S598564Tegileridine versus Sufentanil Patient-Controlled Intravenous Analgesia for Gastrointestinal Recovery in Elderly Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trialhttps://www.dovepress.com/tegileridine-versus-sufentanil-patient-controlled-intravenous-analgesi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 22 Jul 2026 18:35:00 +1200https://doi.org/10.2147/DDDT.S620139Association of Busulfan Exposure with Event-Free Survival in a Chinese Pediatric Cohort: A Multicenter, Prospective Cohort Studyhttps://www.dovepress.com/association-of-busulfan-exposure-with-event-free-survival-in-a-chinese-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 22 Jul 2026 18:15:00 +1200https://doi.org/10.2147/DDDT.S593835Risk of Bone Mineral Density Loss Associated with GLP-1 Receptor Agonists in Overweight COPD Populations [Letter]https://www.dovepress.com/risk-of-bone-mineral-density-loss-associated-with-glp-1-receptor-agoni-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 22 Jul 2026 17:00:00 +1200https://doi.org/10.2147/DDDT.S640490Clinical Applicability of Early Hemidiaphragmatic Paralysis Monitoring After Supraclavicular Brachial Plexus Block [Letter]https://www.dovepress.com/clinical-applicability-of-early-hemidiaphragmatic-paralysis-monitoring-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 22 Jul 2026 16:55:00 +1200https://doi.org/10.2147/DDDT.S640957Methodological Considerations in the Bioequivalence Assessment of Recombinant Human Serum Albumin [Letter]https://www.dovepress.com/methodological-considerations-in-the-bioequivalence-assessment-of-reco-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 22 Jul 2026 16:30:00 +1200https://doi.org/10.2147/DDDT.S639670Deciphering the Multi-Target Therapeutic Mechanisms of Traditional Chinese Medicine Against Alzheimer’s Disease: A Network Pharmacology Perspectivehttps://www.dovepress.com/deciphering-the-multi-target-therapeutic-mechanisms-of-traditional-chi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 22 Jul 2026 16:05:00 +1200https://doi.org/10.2147/DDDT.S597886Methodological Considerations on the Longitudinal Analysis of Polymyxin B‑Induced Kidney Injury [Letter]https://www.dovepress.com/methodological-considerations-on-the-longitudinal-analysis-of-polymyxi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 21 Jul 2026 23:55:00 +1200https://doi.org/10.2147/DDDT.S639804Toward Model-Informed Precision Dosing of Imipenem: Multicenter External Validation of Population Pharmacokinetic Models in Adult Critically Ill Patientshttps://www.dovepress.com/toward-model-informed-precision-dosing-of-imipenem-multicenter-externa-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 21 Jul 2026 18:15:00 +1200https://doi.org/10.2147/DDDT.S617895Comparison of Incidence of Respiratory Depression Between Ciprofol versus Propofol for Procedural Sedation During First-Trimester Surgical Abortion: A Randomized Controlled Trialhttps://www.dovepress.com/comparison-of-incidence-of-respiratory-depression-between-ciprofol-ver-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 21 Jul 2026 17:05:00 +1200https://doi.org/10.2147/DDDT.S604735Short-Term Glycemic Outcomes Associated with Imeglimin Use Among Patients with Type 2 Diabetes Mellitus: A Prospective Observational Studyhttps://www.dovepress.com/short-term-glycemic-outcomes-associated-with-imeglimin-use-among-patie-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapySat, 18 Jul 2026 22:20:00 +1200https://doi.org/10.2147/DDDT.S601458The Effect of Food on the Pharmacokinetics and Gastrointestinal Tolerability of Bersiporocin, a Novel Oral Prolyl-tRNA-Synthetase Inhibitorhttps://www.dovepress.com/the-effect-of-food-on-the-pharmacokinetics-and-gastrointestinal-tolera-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 17 Jul 2026 04:30:00 +1200https://doi.org/10.2147/DDDT.S609676Comparison of the ED90 of Esketamine for Suppressing Laryngeal Mask Airway Insertion Responses During Propofol Induction with or without Intravenous Lidocaine Pretreatment: A Randomized Double-Blind Dose-Finding Trialhttps://www.dovepress.com/comparison-of-the-ed90-of-esketamine-for-suppressing-laryngeal-mask-ai-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 16 Jul 2026 21:55:00 +1200https://doi.org/10.2147/DDDT.S609448Safety of Short-T erm Low-Dose Olanzapine in Patients with Cancer and Diabetes Receiving Cisplatin-Based Chemotherapy: A Retrospective TriNetX Cohort Studyhttps://www.dovepress.com/safety-of-short-term-low-dose-olanzapine-in-patients-with-cancer-and-d-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 16 Jul 2026 19:05:00 +1200https://doi.org/10.2147/DDDT.S615968The Effect of Esketamine on Peripheral Vascular Resistance in Elderly Patients During Anesthesia Induction: A Single-Center, Double-Blind, Prospective, Randomized Controlled Studyhttps://www.dovepress.com/the-effect-of-esketamine-on-peripheral-vascular-resistance-in-elderly--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 16 Jul 2026 19:00:00 +1200https://doi.org/10.2147/DDDT.S607757Bicaudal‑C1 in Cancer: Molecular Mechanisms and Therapeutic Strategies Integrating Chinese and Western Medicinehttps://www.dovepress.com/bicaudalc1-in-cancer-molecular-mechanisms-and-therapeutic-strategies-i-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 15 Jul 2026 17:25:00 +1200https://doi.org/10.2147/DDDT.S606851Obinutuzumab as a Rescue and Maintenance Strategy in Children with Difficult-to-Treat Nephrotic Syndrome After Rituximab-Based Treatment Failure or Intolerance: A Preliminary Single-Center Real-World Retrospective Studyhttps://www.dovepress.com/obinutuzumab-as-a-rescue-and-maintenance-strategy-in-children-with-dif-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 15 Jul 2026 04:30:00 +1200https://doi.org/10.2147/DDDT.S619807Early Detection and Temporal Progression of Hemidiaphragmatic Paralysis After Supraclavicular Brachial Plexus Block with 20 mL vs 30 mL Ropivacaine: A Randomized Controlled Trialhttps://www.dovepress.com/early-detection-and-temporal-progression-of-hemidiaphragmatic-paralysi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 15 Jul 2026 00:25:00 +1200https://doi.org/10.2147/DDDT.S598288Comparative Risk of Psoriatic Arthritis in Type 2 Diabetes: An Emulated Target Trial of SGLT2 Inhibitors vs. GLP-1 Receptor Agonistshttps://www.dovepress.com/comparative-risk-of-psoriatic-arthritis-in-type-2-diabetes-an-emulated-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 15 Jul 2026 00:10:00 +1200https://doi.org/10.2147/DDDT.S614222Methodological Concerns Regarding ED95 Estimation and Outcome Interpretation in the Remimazolam Dose-Finding Study for HIFU Ablation [Letter]https://www.dovepress.com/methodological-concerns-regarding-ed95-estimation-and-outcome-interpre-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 19:50:00 +1200https://doi.org/10.2147/DDDT.S637737Real-World Comparative Weight Loss of GLP-1 Receptor Agonists in the All of Us Research Program: A Retrospective Cohort Studyhttps://www.dovepress.com/real-world-comparative-weight-loss-of-glp-1-receptor-agonists-in-the-a-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 04:25:00 +1200https://doi.org/10.2147/DDDT.S604247Targeting Bruton’s Tyrosine Kinase (BTK) in Autoimmunity: Achievements, Opportunities and Challengeshttps://www.dovepress.com/targeting-brutons-tyrosine-kinase-btk-in-autoimmunity-achievements-opp-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 04:05:00 +1200https://doi.org/10.2147/DDDT.S568214Effect of Oliceridine on the Acute Postoperative Pain Management After Elective Cesarean Delivery: A Randomized Non-Inferiority Trialhttps://www.dovepress.com/effect-of-oliceridine-on-the-acute-postoperative-pain-management-after-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 03:05:00 +1200https://doi.org/10.2147/DDDT.S603352Tumor Assembloids as Three-Dimensional Platforms for Modeling Drug Delivery Barriers: Construction Strategies, Applications, and Translational Challengeshttps://www.dovepress.com/tumor-assembloids-as-three-dimensional-platforms-for-modeling-drug-del-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 02:00:00 +1200https://doi.org/10.2147/DDDT.S618870Oliceridine versus Sufentanil on Postoperative Nausea and Vomiting in Women Undergoing Gynecological Laparoscopic Surgery: A Randomized Double‑Blind Controlled Trialhttps://www.dovepress.com/oliceridine-versus-sufentanil-on-postoperative-nausea-and-vomiting-in--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 01:30:00 +1200https://doi.org/10.2147/DDDT.S621409Perioperative Butorphanol for the Prevention of Postoperative Pulmonary Complications After Thoracoscopic Lung Resection: A Randomized, Double-Blind, Placebo-Controlled Trialhttps://www.dovepress.com/perioperative-butorphanol-for-the-prevention-of-postoperative-pulmonar-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 01:25:00 +1200https://doi.org/10.2147/DDDT.S621698Dexamethasone Alone versus Combined with Droperidol for Preventing Postoperative Nausea and Vomiting in Gynecological Day Surgery Under Ciprofol-Alfentanil Anesthesia: A Randomized Double-Blind Controlled Trialhttps://www.dovepress.com/dexamethasone-alone-versus-combined-with-droperidol-for-preventing-pos-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 14 Jul 2026 01:10:00 +1200https://doi.org/10.2147/DDDT.S625824The MEC90 of Ropivacaine for Ultrasound-Guided Pectoral Nerve Block Type II for Modified Radical Mastectomy: A Biased-Coin Up-and-Down Sequential Trialhttps://www.dovepress.com/the-mec90-of-ropivacaine-for-ultrasound-guided-pectoral-nerve-block-ty-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 13 Jul 2026 20:40:00 +1200https://doi.org/10.2147/DDDT.S6124210.06% Ropivacaine Combined with Double-Hole Dural Puncture Epidural Analgesia in Labor for Primiparous Women: A Prospective Randomized Controlled Trialhttps://www.dovepress.com/006-ropivacaine-combined-with-double-hole-dural-puncture-epidural-anal-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 10 Jul 2026 14:10:00 +1200https://doi.org/10.2147/DDDT.S617452