Drug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19New articles released by Dove Press for Drug Design, Development and Therapyen-us2026, Dove Pressangela@dovepress.com (Angela Jones)Dove Press Drug Design, Development and TherapyDrug Design, Development and Therapyhttps://www.dovepress.com/feed/journal/19https://www.dovepress.com/assets/img/addon/rss-banner.jpg140140Brain Endothelial Glycocalyx as a Blood-Facing Translational Interface in Alzheimer’s Disease: Beyond “Leaky” Barriers Toward Repair-First Stratificationhttps://www.dovepress.com/brain-endothelial-glycocalyx-as-a-blood-facing-translational-interface-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 26 Jun 2026 20:15:00 +1200https://doi.org/10.2147/DDDT.S619901Plumbagin Induces Ferroptosis in Nonfunctioning Pituitary Adenomas via Nrf2/FTH1-Dependent Ferritinophagyhttps://www.dovepress.com/plumbagin-induces-ferroptosis-in-nonfunctioning-pituitary-adenomas-via-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 26 Jun 2026 18:15:00 +1200https://doi.org/10.2147/DDDT.S564608Effect of Titrated Dexmedetomidine versus Esmolol on Postoperative Myocardial Injury in High-Risk Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trialhttps://www.dovepress.com/effect-of-titrated-dexmedetomidine-versus-esmolol-on-postoperative-myo-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 26 Jun 2026 17:50:00 +1200https://doi.org/10.2147/DDDT.S602260A Review of Medicinal Plants from the Anak Dalam Tribe of Jambi: An Evaluation of Their Potential for Diabetic Wound Healing Effects—Current Status and Future Perspectiveshttps://www.dovepress.com/a-review-of-medicinal-plants-from-the-anak-dalam-tribe-of-jambi-an-eva-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 26 Jun 2026 00:10:00 +1200https://doi.org/10.2147/DDDT.S602665Clinical Impact of MeltDose Technology Extended-Release Tacrolimus (LCPT) in Solid Organ Transplantation: A Systematic Reviewhttps://www.dovepress.com/clinical-impact-of-meltdose-technology-extended-release-tacrolimus-lcp-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 25 Jun 2026 17:35:00 +1200https://doi.org/10.2147/DDDT.S613201Beyond Terminal Blockade: A Mechanism-Based Approach to Complement Inhibitor Selection in Paroxysmal Nocturnal Hemoglobinuriahttps://www.dovepress.com/beyond-terminal-blockade-a-mechanism-based-approach-to-complement-inhi-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 25 Jun 2026 12:40:00 +1200https://doi.org/10.2147/DDDT.S624829Interpreting Rituximab Response in Seronegative Membranous Nephropathy [Response to Letter]https://www.dovepress.com/interpreting-rituximab-response-in-seronegative-membranous-nephropat-2-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 25 Jun 2026 04:15:00 +1200https://doi.org/10.2147/DDDT.S631149Potential Hepatoprotective Effects of Adenosine Triphosphate Against Olaparib-Induced Oxidative Liver Injury: An Experimental Rat Modelhttps://www.dovepress.com/potential-hepatoprotective-effects-of-adenosine-triphosphate-against-o-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyWed, 24 Jun 2026 16:25:00 +1200https://doi.org/10.2147/DDDT.S613667Is Thoracic Paravertebral Block Truly Superior to Erector Spinae Plane Block? Re-Evaluating the Evidence from a Recovery Perspective [Letter]https://www.dovepress.com/is-thoracic-paravertebral-block-truly-superior-to-erector-spinae-plane-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:50:00 +1200https://doi.org/10.2147/DDDT.S631849Granisetron Reduces Norepinephrine Requirement for Preventing Post‑Induction Hypotension in Elderly Patients Undergoing Laparoscopic Gastrointestinal Surgeryhttps://www.dovepress.com/granisetron-reduces-norepinephrine-requirement-for-preventing-postindu-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:45:00 +1200https://doi.org/10.2147/DDDT.S609499Beyond Indication Expansion: Aligning Evidence, Reimbursement, and Access in Multi-Indication Oncology Drugs [Letter]https://www.dovepress.com/beyond-indication-expansion-aligning-evidence-reimbursement-and-access-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:40:00 +1200https://doi.org/10.2147/DDDT.S625668Remodeling the Stroma: The Role of ncRNAs in Cancer-Associated Fibroblasts and Therapeutic Implications for Digestive Tumorshttps://www.dovepress.com/remodeling-the-stroma-the-role-of-ncrnas-in-cancer-associated-fibrobla-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:30:00 +1200https://doi.org/10.2147/DDDT.S600029Swarm Intelligence in Drug Discovery Applications: Unlocking Deeper Insights on the Identification and Optimization of Potential Drug Candidateshttps://www.dovepress.com/swarm-intelligence-in-drug-discovery-applications-unlocking-deeper-ins-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 15:25:00 +1200https://doi.org/10.2147/DDDT.S561251The Bonferroni Paradox: When Secondary Analyses are Held to a Stricter Standard Than the Primary Endpoint [Letter]https://www.dovepress.com/the-bonferroni-paradox-when-secondary-analyses-are-held-to-a-stricter--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyTue, 23 Jun 2026 02:20:00 +1200https://doi.org/10.2147/DDDT.S633921Effects of Liposomal Bupivacaine for Superficial Parasternial Intercostal Plane Block on Postoperative Stress and Analgesia in Patients Undergoing Median Sternotomy: A Prospective, Randomized, Double-Blind Trialhttps://www.dovepress.com/effects-of-liposomal-bupivacaine-for-superficial-parasternial-intercos-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 22 Jun 2026 19:25:00 +1200https://doi.org/10.2147/DDDT.S597889Tubulin Post-Translational Modifications in Cardiovascular Diseases: Emerging Mechanisms and Therapeutic Modulation by Traditional Chinese Medicinehttps://www.dovepress.com/tubulin-post-translational-modifications-in-cardiovascular-diseases-em-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 22 Jun 2026 18:00:00 +1200https://doi.org/10.2147/DDDT.S616766Bolus versus Continuous Infusion of Esketamine for Prevention of Postpartum Depression After Caesarean Delivery: A Randomized, Double-Blind, Controlled Trialhttps://www.dovepress.com/bolus-versus-continuous-infusion-of-esketamine-for-prevention-of-postp-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 22 Jun 2026 15:05:00 +1200https://doi.org/10.2147/DDDT.S601347Discharge Readiness After Propofol with or without Esketamine for Flexible Bronchoscopy: A Randomized Non-Inferiority Trialhttps://www.dovepress.com/discharge-readiness-after-propofol-with-or-without-esketamine-for-flex-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 22 Jun 2026 14:10:00 +1200https://doi.org/10.2147/DDDT.S612153Enhanced Recovery and Postoperative Analgesia After Laparoscopic Myomectomy: A Randomized Controlled Trial Comparing Total Intravenous Anesthesia, Transversus Abdominis Plane Block with Rectus Sheath Block, and Quadratus Lumborum Blockhttps://www.dovepress.com/enhanced-recovery-and-postoperative-analgesia-after-laparoscopic-myome-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyMon, 22 Jun 2026 14:05:00 +1200https://doi.org/10.2147/DDDT.S622304Population Pharmacokinetics and Dose Optimization of Vancomycin in Adult Cancer Patientshttps://www.dovepress.com/population-pharmacokinetics-and-dose-optimization-of-vancomycin-in-adu-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapySat, 20 Jun 2026 17:00:00 +1200https://doi.org/10.2147/DDDT.S608206Molecular Mechanisms Underlying the Anti-Diabetic Effects of Astragaloside IV: A Focus on Signaling Pathwayshttps://www.dovepress.com/molecular-mechanisms-underlying-the-anti-diabetic-effects-of-astragalo-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapySat, 20 Jun 2026 15:45:00 +1200https://doi.org/10.2147/DDDT.S600460From Phytochemistry to Drug Discovery: A Systematic Review of Multitarget Pharmacology and Lead Compound Prioritization of Piper crocatum Ruiz & Pavhttps://www.dovepress.com/from-phytochemistry-to-drug-discovery-a-systematic-review-of-multitarg-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapySat, 20 Jun 2026 00:40:00 +1200https://doi.org/10.2147/DDDT.S611626Remimazolam versus Propofol in Renal Allograft Surgery: A Methodological Commentary [Letter]https://www.dovepress.com/remimazolam-versus-propofol-in-renal-allograft-surgery-a-methodologica-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 19 Jun 2026 20:20:00 +1200https://doi.org/10.2147/DDDT.S633660Artificial Intelligence in Selected Domains of Drug Discovery: A Critical Narrative Reviewhttps://www.dovepress.com/artificial-intelligence-in-selected-domains-of-drug-discovery-a-critic-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 19 Jun 2026 16:15:00 +1200https://doi.org/10.2147/DDDT.S607228In-vivo Antioxidant Effects of Emodin on Ischemia-Reperfusion Injury of Rat’s Skeletal Musclehttps://www.dovepress.com/in-vivo-antioxidant-effects-of-emodin-on-ischemia-reperfusion-injury-o-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyFri, 19 Jun 2026 03:30:00 +1200https://doi.org/10.2147/DDDT.S618630Artemisinin-Related Therapeutic Strategies for Autoimmune Thyroiditis: Chemokine–Receptor Networks, Spatial Thyroid Biology, and Molecular Mechanismshttps://www.dovepress.com/artemisinin-related-therapeutic-strategies-for-autoimmune-thyroiditis--peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 18 Jun 2026 22:35:00 +1200https://doi.org/10.2147/DDDT.S614133Optimizing Flumatinib Therapy in Chinese Chronic-Phase Chronic Myeloid Leukemia Based on Therapeutic Drug Monitoringhttps://www.dovepress.com/optimizing-flumatinib-therapy-in-chinese-chronic-phase-chronic-myeloid-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 18 Jun 2026 22:25:00 +1200https://doi.org/10.2147/DDDT.S612207The Pan-Inhibitor of Aurora Kinases Danusertib Induces Apoptosis and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition in Human Breast Cancer Cells [Retraction]https://www.dovepress.com/retraction-the-pan-inhibitor-of-aurora-kinases-danusertib-induces-apop-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 18 Jun 2026 18:30:00 +1200https://doi.org/10.2147/DDDT.S633634Plumbagin Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial to Mesenchymal Transition Involving PI3K/Akt/mTOR-Mediated Pathway in Human Pancreatic Cancer Cells [Retraction]https://www.dovepress.com/retraction-plumbagin-induces-cell-cycle-arrest-and-autophagy-and-suppr-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 18 Jun 2026 18:25:00 +1200https://doi.org/10.2147/DDDT.S633642Alisertib Induces Cell Cycle Arrest and Autophagy and Suppresses Epithelial-to-Mesenchymal Transition Involving PI3K/Akt/mTOR and Sirtuin 1-Mediated signaling pathways in Human Pancreatic Cancer Cells [Retraction]https://www.dovepress.com/retraction-alisertib-induces-cell-cycle-arrest-and-autophagy-and-suppr-peer-reviewed-fulltext-article-DDDTDrug Design, Development and TherapyThu, 18 Jun 2026 17:50:00 +1200https://doi.org/10.2147/DDDT.S633636