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Fecal microbiota transplantation: current clinical efficacy and future prospects

Authors Bowman K, Broussard E, Surawicz C

Received 11 April 2015

Accepted for publication 13 July 2015

Published 23 October 2015 Volume 2015:8 Pages 285—291

DOI https://doi.org/10.2147/CEG.S61305

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Professor Andreas M Kaiser

Kathryn A Bowman,1 Elizabeth K Broussard,2 Christina M Surawicz2

1Department of Medicine, 2Division of Gastroenterology, University of Washington School of Medicine, Seattle, WA, USA

Abstract: Fecal microbiota transplantation (FMT) has gained mainstream attention with its remarkable efficacy in treating recurrent Clostridium difficile infection (RCDI) when there are no other effective therapies. Methods of selecting donors and routes of administration vary among studies, but there are now randomized controlled trials showing efficacy of FMT in treating RCDI. Ongoing trials of FMT for other disease such as inflammatory bowel disease are underway; this therapy should not be used for these conditions unless there is strong evidence for efficacy. Long-term safety data are sorely needed, as well as clarification of regulatory concerns.

Keywords: fecal microbiota transplant, recurrent Clostridium difficile infection, Clostridium difficile infection, microbiome, inflammatory bowel disease

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