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Familial association of lung cancer with liver cancer in first-degree relatives

Authors Xu CR, Lin H, Su J, Zhang XC, Huang YS, Yang XN, Zhou Q, Yang JJ, Zhong WZ, Wu YL

Received 26 December 2018

Accepted for publication 3 April 2019

Published 28 June 2019 Volume 2019:11 Pages 5813—5819

DOI https://doi.org/10.2147/CMAR.S199462

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Dr Chien-Feng Li


Chong-Rui Xu,1* Huan Lin,1,2* Jian Su,1 Xu-Chao Zhang,1 Yi-Sheng Huang,3 Xue-Ning Yang,1 Qing Zhou,1 Jin-Ji Yang,1 Wen-Zhao Zhong,1 Yi-Long Wu1

1Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of China; 2The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, People’s Republic of China; 3Affiliated Zhongshan Hospital of Guangdong Medical University, Zhongshan, Guangdong, People’s Republic of China

*These authors contributed equally to this work

Purpose: Besides the smoking and occupational exposures, heritable factors have been proven to be a risk factor for lung cancer by several population-based studies, which would misestimate the risk of lung cancer.
Patients and methods: To quantify the magnitude of the high risk of lung cancer with family history, we performed a case-based study with 1373 enrolled individuals, which may be more accurate than a population-based study.
Results: Risk of lung cancer was higher in people with lung cancer family history than in the control group (OR 2.50, p<0.001). Individuals with family history of liver cancer also had a higher risk of lung cancer than the control group (OR 1.78, p=0.038) while there was no significant difference within the individuals with family history of colorectal cancer, esophageal cancer, nasopharyngeal cancer or breast cancer. Furthermore, the risk of lung cancer in the subjects with early-onset cancers (age <50 years) was higher than the later-onset cancers (age ≥50 years), especially in individuals with family history of liver cancer (OR 9.24 vs 1.39). Risk of lung cancer in females with family history of lung cancer or liver cancer was higher than in males.
Conclusion: The results of this study proved that the familial aggregation of lung cancer and liver cancer manifests higher risks of lung cancer, supporting the hypothesis that lung cancer and liver cancer are attributable to common familial predisposition.

Keywords: lung cancer, liver cancer, family history

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