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Factors associated with adherence to nucleos(t)ide analogs in chronic hepatitis B patients: results from a 1-year follow-up study

Authors Peng J, Yin J, Cai S, Yu T, Zhong C

Received 21 July 2014

Accepted for publication 29 September 2014

Published 7 January 2015 Volume 2015:9 Pages 41—45

DOI https://doi.org/10.2147/PPA.S71510

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Johnny Chen

Jie Peng, Junhua Yin, Shaohang Cai, Tao Yu, Chunxiu Zhong

Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China

Abstract: Little is known about the factors associated with patient compliance with nucleos(t)ide analog (NUC) treatment for chronic hepatitis B (CHB). The purpose of this study was to examine the association between sociodemographic and clinical characteristics and adherence to NUCs among patients with CHB. A total of 211 CHB patients receiving NUC monotherapy were asked to report the number of prescribed doses of medication they had taken during the last 90 days. A total of four 3-month adherence scores were averaged to obtain a combined rate of NUC adherence during a 1-year follow up period. The mean age of the patients was 29.6 years, 79% were men, and 68% had no prior NUC treatment for CHB. Females, patients without a previous NUC treatment, and those who had NUC drug resistance showed better adherence to NUC treatment, and compliance was better with telbivudine than with lamivudine and entecavir.

Keywords: chronic hepatitis B, nucleos(t)ide analogues, adherence, follow-up, resistance

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