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Fabrication of ultrasmall WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy

Authors Liao W, Zhang L, Zhong Y, Shen Y, Li C, An N

Received 24 December 2017

Accepted for publication 22 February 2018

Published 5 April 2018 Volume 2018:11 Pages 1949—1960

DOI https://doi.org/10.2147/OTT.S160748

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr XuYu Yang


Wenyun Liao,1 Li Zhang,1 Yunhua Zhong,2 Yuan Shen,1 Changlin Li,1 Na An1

1Department of Emergency, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, People’s Republic of China; 2Department of Geriatrics, The First People’s Hospital of Yunnan Province, Kunming University of Science and Technology, Kunming, People’s Republic of China

Introduction: The consolidation of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. In this study, a multifunctional platform by WS2 quantum dots (WQDs)-coated doxorubicin (DOX)-loaded periodic mesoporous organosilicas (PMOs-DOX@WQDs) nanoparticles were fabricated for the first time, and which exhibits good potential for synergistic chemo-photothermal therapy.
Materials and methods: The structure, light-mediated drug release behavior, photothermal effect, and synergistic therapeutic efficiency of PMOs-DOX@WQDs to HCT-116 colon cancer cells were investigated. The thioether-bridged PMOs exhibit a high DOX loading capacity of 66.7 µg mg−1. The gating of the PMOs not only improve the drug loading capacity but also introduce the dual-stimuli-responsive performance. Furthermore, the as-synthesized PMOs-DOX@WQDs nanoparticles can efficiently generate heat to the hyperthermia temperature with near infrared laser irradiation.
Results: It was confirmed that PMOs-DOX@WQDs exhibit remarkable photothermal effect and light-triggered faster release of DOX. More importantly, it was reasonable to attribute the efficient anti-tumor efficiency of PMOs-DOX@WQDs.
Conclusion: The in vitro experimental results confirm that the fabricated nanocarrier exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the WQD-coated PMOs present promising applications in cancer therapy.

Keywords: periodic mesoporous organosilica, WS2 quantum dots, chemo-photothermal therapy, drug delivery
 

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