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Extramedullary hematopoiesis secondary to malignant solid tumors: a case report and literature review

Authors Bao Y, Liu Z, Guo M, Li B, Sun X, Wang L

Received 6 January 2018

Accepted for publication 2 April 2018

Published 8 June 2018 Volume 2018:10 Pages 1461—1470

DOI https://doi.org/10.2147/CMAR.S161746

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Kenan Onel


Youting Bao,1,2,* Zhichao Liu,2,3,* Meiying Guo,2,4 Butuo Li,2,5 Xindong Sun,2 Linlin Wang2

1Department of Oncology, Clinical College, Weifang Medical University, Weifang 261053, 2Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Science, Jinan 250117, 3Department of Oncology, School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, 4Medical College of Shandong University, Jinan 250012, 5Department of Oncology, Tianjin Medical University, Tianjin 300070, People’s Republic of China

*These authors contributed equally to this work

Abstract:
Extramedullary hematopoiesis (EMH) usually occurs in hematological disease, but more rarely develops in cases of malignant solid tumors. Due to its features on computed tomography (CT) and magnetic resonance imaging (MRI) that are atypical, EMH in tumor patients might easily be misdiagnosed as metastasis leading to the improper TNM staging and inappropriate therapy. Here, we reported the first case of pleural EMH occurring in a patient with esophageal carcinoma whose pleural lesion was first diagnosed as metastasis and confirmed EMH after the needle biopsy. In addition, a retrospective review was conducted by analyzing patients presented with EMH with malignant solid tumors from PubMed and Medline databases. A total of 42 solid tumor patients with EMH were enrolled, and breast cancer was the most common (n=13, 31.0%), followed by renal carcinoma (n=7, 16.7%) and lung cancer (n=6, 14.3%). A wide variety of body sites may be affected by EMH in malignant solid tumor patients, of which the lymph nodes (n=8, 19.0%) and liver (n=7, 16.7%) were the most common, followed by the kidney (n=6, 14.3%). All patients were diagnosed with EMH by excision, biopsy, or autopsy. Treatment strategies for EMH included surgery (n=25, 59.5%), hydroxyurea (n=1, 2.4%), and blood transfusions (n=2, 4.8%); a further 14 patients (33.3%) were subjected to clinical observation without intervention. Of the patients for whom outcome was reported, 10 patients maintained a good performance status (23.8%) and a further six patients died from the malignant tumor. This was the first study to summarize the presentations of EMH in malignant solid tumors, and our findings might provide some useful guidance for clinical practice, especially for treating patients harboring nonresponse lesions during the antitumor treatment.

Keywords: extramedullary hematopoiesis, cancer, sarcoma, imaging features, biopsy

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