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Extragastrointestinal Stromal Tumor Presenting as a Recurrent Vaginal Mass: Case Report

Authors Liu S, Pan P, Han B, Wang J, Sun M, Sun Y

Received 17 October 2020

Accepted for publication 24 December 2020

Published 10 February 2021 Volume 2021:14 Pages 959—965

DOI https://doi.org/10.2147/OTT.S284101

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Yong Teng


Shuai Liu,1 Pan Pan,2 Bing Han,3 Jingnan Wang,1 Meili Sun,1 Yuping Sun1

1Department of Oncology, Jinan Central Hospital Affiliated to Shandong University; Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, Shandong, People’s Republic of China; 2Department of Pathology, Jinan Central Hospital Affiliated to Shandong University; Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, Shandong, People’s Republic of China; 3Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, People’s Republic of China

Correspondence: Yuping Sun Tel +86-13370582181
Email 13370582181@163.com

Abstract: Gastrointestinal stromal tumors (GISTs) are the dominant mesenchymal tumors of the digestive tract. Extragastrointestinal stromal tumors (EGISTs) usually originate outside the gastrointestinal tract without connection to the gastric or intestinal wall. However, EGISTs arising from the vaginal wall are very rare. Here, we report a case of EGIST that occurred in the vagina of a 60-year-old woman. The tumor was present in the posterior vaginal wall. It was surgically excised, and histological examination revealed spindle cell morphology with up to 14 mitoses per 50 high power field (HPF) and necrosis with the tumor-negative margins. Immunohistochemical analyses showed strongly positive CD34, CD117, and DOG-1 expression, but negative SMA, S-100, CD10, desmin, and actin expression. The patient underwent surgery and is currently being followed up. A literature review of EGSTs and treatments is also discussed in this report.

Keywords: extragastrointestinal stromal tumors, vagina, c-kit, mutation

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