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Extracellular Vesicle-Related Thrombosis in Viral Infection

Authors Nomura S, Taniura T, Ito T

Received 3 June 2020

Accepted for publication 28 July 2020

Published 26 August 2020 Volume 2020:13 Pages 559—568


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Shosaku Nomura,1 Takehito Taniura,2 Tomoki Ito1

1First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan; 2Division of Internal Medicine, Daiwa Hospital, Suita, Japan

Correspondence: Shosaku Nomura
First Department of Internal Medicine, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1010, Japan
Tel + 81 72 804 2754
Fax + 81 72 804 2041

Abstract: Although the outcomes of viral infectious diseases are remarkably varied, most infections cause acute diseases after a short period. Novel coronavirus disease 2019, which recently spread worldwide, is no exception. Extracellular vesicles (EVs) are small circulating membrane-enclosed entities shed from the cell surface in response to cell activation or apoptosis. EVs transport various kinds of bioactive molecules between cells, including functional RNAs, such as viral RNAs and proteins. Therefore, when EVs are at high levels, changes in cell activation, inflammation, angioplasty and transportation suggest that EVs are associated with various diseases. Clinical research on EVs includes studies on the coagulatory system. In particular, abnormal enhancement of the coagulatory system through EVs can cause thrombosis. In this review, we address the functions of EVs, thrombosis, and their involvement in viral infection.

Keywords: viral infection, thrombosis, extracellular vesicle, exosome, microvesicle

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