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Expression of interleukin 1β in gastric cancer tissue and its effects on gastric cancer

Authors Yin S, Lan C, Pei H, Zhu Z

Received 12 August 2015

Accepted for publication 15 October 2015

Published 21 December 2015 Volume 2016:9 Pages 31—35

DOI https://doi.org/10.2147/OTT.S94277

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Ram Prasad

Peer reviewer comments 4

Editor who approved publication: Professor Daniele Santini


Shenglu Yin, Chao Lan, Hui Pei, Zhiqiang Zhu

Emergency Center Department, First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China

Abstract: This study detected the expression level of IL-1β in gastric cancer tissue and paracarcinoma tissue, and also analyzed its relationship with clinical and pathological features, so as to explore the expression of IL-1β in gastric cancer tissue and its effect on gastric cancer. A total of 70 fresh primary gastric cancer tumors and corresponding paracarcinoma tissues away from the tumor-incision edge (≥5 cm) were selected from the First Affiliated Hospital of Zhengzhou University from January to December 2014. Total protein concentration was extracted from tissues with radioimmunoprecipitation assay lysis buffer, and IL-1β content in tissues was detected with enzyme-linked immunosorbent assay. The ratio of cell cytokine content and protein concentration was considered as the relative content of cytokines, and the relationship between relative content of cytokines and clinical data was analyzed. Results indicated that the differences in content of IL-1β in gastric cancer tissues and paracarcinoma tissues had no statistical significance, but the content of IL-1β would rise as tumor size was enlarged, based upon analysis (2.9<4.2 ng/g), and the difference was statistically significant (P<0.05). Furthermore, IL-1β content decreased along with differentiation degree and infiltration depth (3.21<4.15 ng/g, 3.06<3.45 ng/g), but the difference was not statistically significant (P>0.05). Therefore, it can be concluded that IL-1β plays an important role in the occurrence and development of gastric cancer and promotes the treatment of gastric cancer to some extent.

Keywords: interleukin cytokines, paracarcinoma tissues, Helicobacter pylori, enzyme-linked immunosorbent assay

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